What side effects are associated with this type of intervention?

The most common treatments for measuring brain activity, such as MEG and OPM sensors, are generally non-invasive and have minimal side effects. Participants may experience mild discomfort from wearing the sensor cap or from the adhesive used to attach sensors. In rare cases, individuals might feel slight skin irritation or pressure marks. Overall, these techniques are considered safe with no significant adverse effects reported.

What prior FDA approvals exist?

There are no specific FDA approvals mentioned for treatments directly related to the measurement of magnetic fields produced by brain activity, such as the OPM sensor. However, transcranial magnetic stimulation (TMS) is an FDA-approved treatment for certain neurological conditions, including depression and migraine. TMS uses magnetic fields to stimulate nerve cells in the brain and has shown efficacy in clinical trials. This treatment is somewhat related as it involves the use of magnetic fields to influence brain activity.

What other types of research exist?

Promising, novel alternatives to OPM sensors for measuring magnetic fields produced by brain activity include transcranial magnetic stimulation (TMS) and noninvasive vagus nerve stimulation (nVNS). Both technologies are non-invasive and have demonstrated efficacy in clinical trials for neurological conditions.

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OPM MEG Brain Activity Mapping

N/A

Recruiting

Led By Allison Nugent, Ph.D.

Research Sponsored by National Institute of Mental Health (NIMH)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Male or female, aged 18-65

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up throughout protocol

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a new sensor called OPM that measures brain activity by detecting magnetic fields. These sensors can be placed directly on the scalp and offer advantages over traditional methods. It targets healthy adults aged 18-65 who have had an MRI scan. The sensors are placed on a cap and can accurately measure the brain's magnetic fields.

Who is the study for?

Healthy adults aged 18-65 who've had an MRI scan under a specific protocol can join this study. They should be in good health, able to follow the study's procedures, and available for its duration. People with metal in their body that affects MEG recordings cannot participate.

What is being tested?

The trial is testing a new brain activity sensor called OPM against the traditional SQUID MEG. Participants will wear special equipment on their head and complete tasks involving touch, sight, sound, or language stimuli while magnetic fields are measured.

What are the potential side effects?

There are no significant side effects expected from participating in this trial as it involves non-invasive measurement of brain activity using advanced imaging technology.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 65 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ throughout protocol

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~throughout protocol

This trial's timeline: 3 weeks for screening, Varies for treatment, and throughout protocol for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

array characterization metrics

Secondary study objectives

Somatotopic representations

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: OPM Array studiesExperimental Treatment2 Interventions

Testing of a final 49-61 channel OPM MEG system and any interim arrays

0 / 1Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Treatments like transcranial magnetic stimulation (TMS) and other neuromodulation techniques work by using electromagnetic fields to modulate neural activity in the brain. These treatments can alter brain function, potentially improving symptoms in various neurological conditions by targeting specific areas of the brain. This is particularly relevant for patients as it helps them understand how these treatments can influence brain activity and contribute to their overall neurological health.

Effect of transcranial pulsed electromagnetic fields (T-PEMF) on functional rate of force development and movement speed in persons with Parkinson's disease: A randomized clinical trial.