What side effects are associated with this type of intervention?

Common treatments for Basal Cell Carcinoma (BCC) include Mohs surgery and photodynamic therapy (PDT). Mohs surgery, which involves the precise removal of cancerous tissue layer by layer, can lead to side effects such as pain, bleeding, infection, and scarring. Photodynamic therapy, which uses a photosensitizing agent and light to destroy cancer cells, may cause side effects like redness, swelling, pain, and photosensitivity in the treated area. Both treatments are generally effective but come with these potential side effects that patients should discuss with their healthcare provider.

What prior FDA approvals exist?

The FDA has approved several treatments for Basal Cell Carcinoma (BCC), including surgical methods like Mohs micrographic surgery, which is highly effective for removing cancerous tissue while sparing healthy tissue. Photodynamic therapy (PDT) using photosensitizing agents like aminolevulinic acid (ALA) followed by light exposure has also been approved for superficial BCC. Additionally, topical treatments such as imiquimod and 5-fluorouracil, as well as oral medications like vismodegib and sonidegib, which are hedgehog pathway inhibitors, have received FDA approval. These treatments focus on different mechanisms, including immune response modulation, direct cytotoxicity, and molecular pathway inhibition.

What other types of research exist?

Promising, novel alternatives to Two Photon Fluorescence Microscopy for Basal Cell Carcinoma patients include photodynamic therapy (PDT) with aminolevulinic acid or methyl aminolevulinate, which offers targeted treatment with high precision. Additionally, intense pulsed light (IPL) and advanced laser therapies, such as pulsed dye laser and long-pulsed Nd:YAG laser, are effective for both imaging and treatment of BCC. These modalities provide high-resolution imaging and targeted treatment, making them viable options for 2024.

← Back to Search

Imaging

Two Photon Microscopy for Skin Cancer

N/A

Recruiting

Led By Michael G Giacomelli, Ph.D

Research Sponsored by University of Rochester

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during mohs surgery

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to see if a special imaging technique called TPFM can help doctors find any remaining cancer cells during skin cancer surgery. It focuses on patients with basal cell carcinoma and compares TPFM results with other methods to ensure accuracy.

Who is the study for?

This trial is for individuals who can read and understand a consent form and are currently undergoing Mohs surgery for basal cell carcinoma (BCC) at the location where the study is being conducted.

What is being tested?

The study is testing two photon fluorescence microscopy to see if it's as good as the standard frozen section histology in identifying cancerous tissue during Mohs surgery for BCC.

What are the potential side effects?

Since this trial involves imaging with two photon microscopy, there are no direct side effects from drugs or interventions. The procedure may involve typical risks associated with clinical imaging.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during mohs surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during mohs surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and during mohs surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Agreement between frozen sections and two photon microscopy on Mohs margins

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: TPFM imaging of surgical marginsExperimental Treatment1 Intervention

Patients will be imaged with TPFM

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Basal Cell Carcinoma (BCC) include Mohs surgery and photodynamic therapy (PDT). Mohs surgery involves the meticulous removal of cancerous tissue layer by layer, with each layer examined under a microscope until no cancer cells remain, ensuring complete removal with minimal damage to surrounding healthy tissue. Photodynamic therapy uses a photosensitizing agent activated by light to produce reactive oxygen species that destroy cancer cells. These treatments are significant for BCC patients as they offer high precision, lower recurrence rates, and better cosmetic outcomes.