Image-Guided Radiosurgery for Brain Tumor
(IG-SRS Trial)

Recruiting in Palo Alto (17 mi)

Overseen byJona Hattangadi-Gluth, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Recruiting

Sponsor: Jona Hattangadi-Gluth

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

This trial uses advanced imaging and precise radiation treatment to help adult patients with 1 to 3 brain metastases. It aims to protect important brain areas during treatment, preserving cognitive functions like memory and attention.

Research Team

Jona Hattangadi-Gluth, MD

Principal Investigator

University of California, San Diego

Eligibility Criteria

Adults over 18 with 1-3 small brain metastases from cancers like lung or breast, who can undergo MRI scans and have a life expectancy over 6 months. They must be able to perform daily activities with mild symptoms at most and participate in neurocognitive tests. Pregnant women, those unable to use contraception, or patients previously treated with whole brain radiation are excluded.

Inclusion Criteria

Willingness/Ability to undergo brain MRI scans

You have one to three small brain tumors, each less than 3 cm in size.

You are expected to live for at least 6 more months.

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Exclusion Criteria

Pregnant or nursing women

Women of childbearing potential unwilling to use adequate contraception

You are not able to undergo a magnetic resonance imaging (MRI) scan with a contrast dye.

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Treatment Details

Interventions

Cognitive Sparing Brain Stereotactic Radiosurgery (SRS) (Radiation Therapy)

Trial OverviewThe trial is testing a precise radiosurgery technique that aims to spare cognitive function while targeting brain tumors. It uses advanced imaging methods to protect critical brain areas during treatment and assesses the effectiveness through biomarkers of radiation response.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Image-guided cognitive sparing brain SRSExperimental Treatment1 Intervention

This is a single arm phase II study where enrolled subjects will receive intracranial SRS will performed identically to standard of care, except for implementing additional imaging techniques and software for additional regional avoidance for cognitive sparing (specifically sparing white matter and the bilateral hippocampus)