Chest Wall Mechanics Study for Heart Disease

Recruiting in Palo Alto (17 mi)

Overseen byLuciana Rodriguez Guerineau, MD

Age: < 18

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: The Hospital for Sick Children

No Placebo Group

Trial Summary

What is the purpose of this trial?This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.

Eligibility Criteria

This trial is for newborns under 28 days old who have had surgery for congenital heart disease and need their chest kept open in the critical care unit. They must weigh over 2 kg, be at least full-term babies, and not require certain advanced respiratory or circulatory support.

Inclusion Criteria

Having a drug screening test in a specialized care unit.

I had heart surgery with a heart-lung machine for a birth defect.

Informed consent provided by parent or primary guardian

+1 more

Exclusion Criteria

I have a heart rhythm problem that affects my blood flow.

My baby was born before 37 weeks or weighed less than 2 kg at surgery time.

You have a severe blood clotting problem or a condition that makes it unsafe to insert a tube through your nose into your stomach.

+3 more

Participant Groups

The study tests how different breathing machine settings affect the chest wall during delayed sternal closure after heart surgery. It uses a special catheter to measure pressure inside the esophagus of these infants.

2Treatment groups

Experimental Treatment

Group I: Univentricular physiologyExperimental Treatment1 Intervention

Neonates with univentricular physiology

Group II: Biventricular physiologyExperimental Treatment1 Intervention

Neonates with biventricular physiology