Surgery vs Stenting for Carotid Artery Stenosis
(ACST-2 Trial)
Recruiting in Palo Alto (17 mi)
+124 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: University of Oxford
No Placebo Group
Trial Summary
What is the purpose of this trial?The trial randomise patients with asymptomatic carotid artery narrowing in whom prompt physical intervention is thought to be needed, but there there is still substantial uncertainty shared by patient and doctor about whether surgery or stenting is the more appropriate choice.
The study is looking at immediate risks (within one month)and at long term benefits
Eligibility Criteria
This trial is for patients with asymptomatic carotid artery narrowing who haven't had symptoms or previous procedures on the affected artery. They must be on medical treatment like statins, have completed any heart procedures, and be able to attend follow-ups. Both surgery (CEA) and stenting (CAS) should be possible options without a clear preference for either.Inclusion Criteria
Tests show both CEA and CAS procedures are suitable for me.
Some type of angiography (eg, MRA or CTA) has already been done that has shown that CEA and CAS would both be anatomically practicable.
I have a narrowed carotid artery without symptoms or previous treatments.
+3 more
Participant Groups
The study compares two treatments for carotid artery narrowing: Carotid Endarterectomy (CEA), which is surgery to remove plaque from inside the carotid artery, and Carotid Artery Stenting (CAS), where a mesh tube is inserted to widen the narrowed part of the artery. It assesses immediate risks and long-term benefits.
2Treatment groups
Active Control
Group I: CEAActive Control1 Intervention
Carotid endarterectomy
Group II: CASActive Control1 Intervention
Carotid Artery Stenting
Carotid Artery Stenting is already approved in European Union, United States, Canada for the following indications:
🇪🇺 Approved in European Union as Carotid Artery Stenting for:
- Symptomatic carotid stenosis ≥70%
- Asymptomatic carotid stenosis >60%
- Symptomatic carotid stenosis 50-69%
🇺🇸 Approved in United States as Carotid Artery Stenting for:
- Symptomatic carotid stenosis ≥70%
- Asymptomatic carotid stenosis >60%
- Symptomatic carotid stenosis 50-69%
🇨🇦 Approved in Canada as Carotid Artery Stenting for:
- Symptomatic carotid stenosis ≥70%
- Asymptomatic carotid stenosis >60%
- Symptomatic carotid stenosis 50-69%
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of Toledo Medical CentreToledo, OH
Foothills Medical CentreCalgary, Canada
Who Is Running the Clinical Trial?
University of OxfordLead Sponsor
NHS Health Technology Assessment ProgrammeCollaborator
BUPA FoundationCollaborator
British Heart FoundationCollaborator