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Realtime Streaming Clinical Use Engine for Medical Escalation (ReSCUE-ME Trial)

N/A
Waitlist Available
Research Sponsored by Icahn School of Medicine at Mount Sinai
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* All patients age 18 or greater who were admitted to a general care unit selected for each arm.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 month

Summary

The escalation of care for patients in a hospitalized setting between nurse practitioner managed services, teaching services, step-down units, and intensive care units is critical for appropriate care for any patient. Often such "triggers" for escalation are initiated based on the nursing evaluation of the patient, followed by physician history and physical exam, then augmented based on laboratory values. These "triggers" can enhance the care of patients without increasing the workload of responder teams. One of the goals in hospital medicine is the earlier identification of patients that require an escalation of care. The study team developed a model through a retrospective analysis of the historical data from the Mount Sinai Data Warehouse (MSDW), which can provide machine learning based triggers for escalation of care (Approved by: IRB-18-00581). This model is called "Medical Early Warning Score ++" (MEWS ++). This IRB seeks to prospectively validate the developed model through a pragmatic clinical trial of using these alerts to trigger an evaluation for appropriateness of escalation of care on two general inpatients wards, one medical and one surgical. These alerts will not change the standard of care. They will simply suggest to the care team that the patient should be further evaluated without specifying a subsequent specific course of action. In other words, these alerts in themselves does not designate any change to the care provider's clinical standard of care. The study team estimates that this study would require the evaluation of \~ 18380 bed movements and approximately 30 months to complete, based on the rate of escalation of care and rate of bed movements in the selected units.

Eligible Conditions
  • Physiologic Monitoring
  • Clinical Deterioration
  • Hospital Medicine

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 month for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Overall rate of care escalation
Secondary study objectives
Mortality Rate
Notification Frequency
Number of calls
+4 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: MEWS++ MonitoringActive Control2 Interventions
This consists of all the patients that will be receiving MEWS++ escalation monitoring and provider alerting.
Group II: Standard of Care MonitoringPlacebo Group1 Intervention
Patients in the control arm will have a score calculated but no alert will be sent.

Find a Location

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor
914 Previous Clinical Trials
567,964 Total Patients Enrolled
Matthew A Levin, MDStudy DirectorIcahn School of Medicine at Mount Sinai
~448 spots leftby Dec 2025