← Back to Search

Exercise for Mild Cognitive Impairment

N/A

Recruiting

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1-7 days prior to intervention , 1-7 days post intervention

Awards & highlights

No Placebo-Only Group

Summary

This trial studies how physical exercise can improve cognition in aging and people with Mild Cognitive Impairment (MCI). It could lead to new ways to improve thinking skills in older adults. #Ageing #Cognition #MCI #Exercise

Who is the study for?

This trial is for adults with mild cognitive impairment (MCI) or those experiencing normal aging who want to improve their cognition. Participants should be able to perform physical exercise and not have any conditions that would prevent them from receiving repetitive transcranial magnetic stimulation.

What is being tested?

The study tests if self-determined intensity interval training, a form of exercise, can change synaptic plasticity in the brain. This could relate to improved thinking abilities in both healthy older adults and those with MCI.

What are the potential side effects?

While specific side effects are not listed, typical risks may include muscle soreness or fatigue due to exercise. The research will monitor participants closely for any adverse reactions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1-7 days prior to intervention , 1-7 days post intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1-7 days prior to intervention , 1-7 days post intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-7 days prior to intervention , 1-7 days post intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change from Baseline Synaptic Plasticity at 4 weeks

Secondary study objectives

Change from Baseline Brain Derived Neurotropic Factor at 4 weeks

Change from Baseline Cognitive function at 4 weeks

Change from Baseline Osteocalcin at 4 weeks

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Active Control

Group I: Exercise Training in Individuals with Mild Cognitive ImpairmentActive Control1 Intervention

Individuals will participate in 3 sessions of Self Determined Intensity Interval training per week for 4 weeks, using a stationary bike at an intensity whereby their Ratings of Perceived exertion (RPE) is challenging. RPE will be measured using a Borg's 6-20 scale. (44). The cycling protocol will include a 3-minute warm-up, five, 1-minute cycling intervals, interspersed with 1.5 minutes of recovery. and a 2-minute cool-down. The RPE will be acquired by asking the participant to provide their rating at the end of the last interval.

Group II: Individuals with Mild Cognitive Impairment and No exerciseActive Control1 Intervention

Group B: Participants in this arm will not experience any intervention during a 4 week period of time.

Group III: Exercise Training in age and sex matched healthy controlsActive Control1 Intervention

Do I qualify?Apply below to find out