Reaching Movements for Mild Cognitive Impairment
Recruiting in Palo Alto (17 mi)
Overseen byJosh Cashaback
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Delaware
Disqualifiers: Traumatic brain injury, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car crashes. The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitation.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Reaching Movements for Mild Cognitive Impairment?
Research suggests that individuals with mild cognitive impairment (MCI) may experience a general slowing of movement, which could indicate a problem with planning or guiding movements. This implies that treatments focusing on improving reaching movements might help address these issues.
12345How does the Reaching Movements treatment differ from other treatments for mild cognitive impairment?
Reaching Movements is unique because it focuses on improving motor control and coordination through specific physical tasks, which may help address the general slowing of movement seen in mild cognitive impairment. Unlike traditional treatments that might focus on medication or cognitive exercises, this approach targets the physical aspect of cognitive decline, potentially offering a novel way to enhance motor skills and quality of life.
24678Eligibility Criteria
This trial is for people aged 50-85 with good vision (natural or corrected) and the ability to reach. It includes those without any neurological disorders as well as individuals clinically diagnosed with amnestic mild cognitive impairment.Inclusion Criteria
I can physically reach and handle objects.
I am between 45 and 90 years old.
I have no history of brain disorders or injuries.
+2 more
Exclusion Criteria
Mild Cognitive Impairment participants with Modified Telephone Interview for Cognitive Status (TICS-m) score greater than 34
Traumatic brain injury, such as concussion, in the last 6 months
Mild Cognitive Impairment participants with Mini-Mental State Examination Second Edition (MMSE-2) score less than 21
+2 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Reaching Task
Participants with mild cognitive impairment and age-matched controls perform decision-making tasks while moving
12 months
Follow-up
Participants are monitored for changes in brain mechanical properties and decision time
4 weeks
Participant Groups
The study focuses on how decision-making and movement are connected in people with mild cognitive impairment. Participants will perform reaching movements while their neural responses are observed to identify potential biomarkers for early disease detection.
2Treatment groups
Experimental Treatment
Active Control
Group I: Reaching taskExperimental Treatment1 Intervention
Mild cognitive impairment participants will make decisions while moving
Group II: Reaching TaskActive Control1 Intervention
Age-match control participants will make decision while moving
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of DelawareNewark, DE
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Who Is Running the Clinical Trial?
University of DelawareLead Sponsor
National Institutes of Health (NIH)Collaborator
National Institute of General Medical Sciences (NIGMS)Collaborator
References
Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. [2019]To evaluate the efficacy of a cognitive-motor program in patients with early Alzheimer disease (AD) who are treated with a cholinesterase inhibitor (ChEI).
Peripheral reaching in Alzheimer's disease and mild cognitive impairment. [2022]Recent evidence has implicated areas within the posterior parietal cortex (PPC) as among the first to show pathophysiological changes in Alzheimer's disease (AD). Focal brain damage to the PPC can cause optic ataxia, a specific deficit in reaching to peripheral targets. The present study describes a novel investigation of peripheral reaching ability in AD and mild cognitive impairment (MCI), to assess whether this deficit is common among these patient groups. Individuals with a diagnosis of mild-to-moderate AD, or MCI, and healthy older adult controls were required to reach to targets presented in central vision or in peripheral vision using two reaching tasks; one in the lateral plane and another presented in radial depth. Pre-registered case-control comparisons identified 1/10 MCI and 3/17 AD patients with significant peripheral reaching deficits at the individual level, but group-level comparisons did not find significantly higher peripheral reaching error in either AD or MCI by comparison to controls. Exploratory analyses showed significantly increased reach duration in both AD and MCI groups relative to controls, accounted for by an extended Deceleration Time of the reach movement. These findings suggest that peripheral reaching deficits like those observed in optic ataxia are not a common feature of AD. However, we show that cognitive decline is associated with a generalised slowing of movement which may indicate a visuomotor deficit in reach planning or online guidance.
Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease. [2022]Little is known about motor function in mild cognitive impairment (MCI) and its relation to the risk of Alzheimer disease (AD).
Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer's disease. [2022]This study aimed to investigate the effects of early-stage Alzheimer's disease (AD) on the reach-to-grasp kinematics and kinetics with and without visual supervision of the grasping arm and hand. Seventeen patients who had been diagnosed with early-stage AD and 17 age- and gender-matched, cognitive normal (CN) adults participated in the experiment. A mirror operating system was designed to block the visual feedback of their grasping hand and forearms but to virtually show grasped targets. The target for reach-to-grasp kinematics was a reflective marker installed on a base; and the target for reach-to-grasp kinetics was a custom-made apparatus installed with two six-component force/torque transducers. Kinematics and kinetic parameters were used to quantify the reach-to-grasp performances. Results showed that the early-stage AD remarkably decreased the reaching speed, reduced the grasping accuracy and increased the transportation variability for reach-to-grasp kinematics. For kinetic analysis, early-stage AD extended the preload duration, disturbed the grip and lift forces coordination, and increased the feedforward proportion in the grasping force control. The AD-related changes in the reach-to-grasp kinematic and kinetic parameters depended on visual feedback and were associated with nervous system function according to correlation analyses with the neuropsychological testing. These results suggest that the abnormal kinematic and kinetic characteristics may correlate with the neuropsychological status of early-stage AD, and that the reach-to-grasp kinematic and kinetic maneuver could potentially be used as a novel tool for non-invasive screening or evaluation of early-stage AD.
Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree? [2022]To determine the 2-year outcome from 16 different current classifications of mild cognitive impairment (MCI) in a population-based sample.
Mild cognitive impairment affects motor control and skill learning. [2017]Mild cognitive impairment (MCI) is a transitional phase between normal cognitive aging and dementia. As the world population is aging rapidly, more MCI patients will be identified, posing significant problems to society. Normal aging is associated with cognitive and motor decline, and MCI brings additional impairments. Compared to healthy older adults, MCI patients show poorer motor control in a variety of tasks. Efficient motor control and skill learning are essential for occupational and leisure purposes; degradation of motor behaviors in MCI patients often adversely affects their health and quality of life. In this article, we first define MCI and describe its pathology and neural correlates. After this, we review cognitive changes and motor control and skill learning in normal aging. This section is followed by a discussion of MCI-related degradation of motor behaviors. Finally, we propose that multicomponent interventions targeting both cognitive and motor domains can improve MCI patients' motor functions. Future research directions are also raised.
Assessment for apraxia in mild cognitive impairment and Alzheimer's dise. [2022]To evaluate apraxia in healthy elderly and in patients diagnosed with Alzheimer's disease (AD) and Mild cognitive impairment (MCI).
Handwriting process variables discriminating mild Alzheimer's disease and mild cognitive impairment. [2022]This study's aims were (a) to examine kinematically the handwriting process of persons with mild cognitive impairment (MCI), compared with those with mild Alzheimer's disease and healthy controls; (b) to assess the importance of these measures for the differentiation of the groups; and (c) to assess characteristics of the handwriting process across different functional tasks. Thirty-one persons with MCI, 22 with mild Alzheimer's disease, and 41 healthy controls performed functional tasks while using a computerized system. We found significant differences between the groups in almost all measures, with the MCI group assuming a position between the other groups. Temporal measures were higher and pressure was lower in more cognitively deteriorated groups. Information gathered about kinematic measures, together with cognitive functioning, allowed us to classify 69% to 72% of the participants correctly, although the classification for the MCI group was relatively poor.