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Behavioral Activation + Medication for Depression & Anxiety in Aging Adults with Orthopedic Procedures (CPMH Trial)

N/A

Recruiting

Led By Ryan Calfee, MD

Research Sponsored by Washington University School of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months post-operatively

Awards & highlights

No Placebo-Only Group

Summary

This trial will test a combined treatment of talk therapy & meds to reduce depression & anxiety in elderly orthopedic patients, compared to usual care.

Who is the study for?

This trial is for adults aged 60 or older who are about to have hip or knee replacement surgery and are experiencing noticeable symptoms of depression or anxiety. They must be able to communicate in English. Those with severe cognitive issues, a history of similar study participation, or acute suicidal thoughts cannot join.

What is being tested?

The study is examining the impact of combining behavioral activation (a therapy focusing on increasing engagement in valued activities) with medication adjustments versus usual care on reducing depression and anxiety in aging adults during orthopedic surgery recovery.

What are the potential side effects?

Potential side effects may include discomfort from engaging in new activities, changes in mood due to behavioral activation techniques, and reactions related to any changes made to medications as part of the optimization process.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months post-operatively

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months post-operatively

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months post-operatively for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

PHQ-ADS

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Control (treatment as usual)Experimental Treatment1 Intervention

Participants in control arm will continue care as usual. They will receive printed resources for supporting sleep hygiene, stress reduction, cognitive and mental health exercises, as well as community resources for older adults.

Group II: Behavioral activation and medication optimizationExperimental Treatment2 Interventions

Behavioral activation (BA) will begin perioperatively and will span across 3 months postoperatively, with sessions approximately weekly or biweekly, depending on patient preference \& health condition. Medications will be reviewed by a team of interventionists to minimize brain-toxic medications and optimize doses of antidepressants and other mental health medications. In-hospital and after discharge, the interventionists' role will include coordinating with the care teams to ensure that medication changes that were introduced preoperatively are maintained.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Behavioral activation

2012

N/A

~100

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