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Diagnostic Test

Glucose Tolerance Testing for Diabetes Risk in Children

N/A
Waitlist Available
Led By Sonia Caprio, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 7-21
Be younger than 65 years old
Must not have
Children previously treated for another endocrinopathy
Children on chronic medications known to alter glucose or insulin metabolism, such as oral steroids, Xeleca, Lithium, and Paxil
Timeline
Screening 3 weeks
Treatment Varies
Follow Up completed at baseline measurement
Awards & highlights
No Placebo-Only Group

Summary

This trial looks at how common diabetes is in children who are either skinny with a family history of diabetes, or overweight/obese with or without a family history of diabetes.

Who is the study for?
This trial is for children aged 7-21 who either have a family history of type 2 diabetes or are overweight/obese. It's not open to kids on certain meds that affect blood sugar, those with other hormonal disorders, or those treated with steroids, antirejection drugs, or chemotherapy.
What is being tested?
The study aims to find out how common carbohydrate intolerance is in lean and overweight/obese kids by using an Oral Glucose Tolerance Test (OGTT). This test involves drinking a sugary solution and measuring blood sugar levels at intervals.
What are the potential side effects?
An OGTT can cause side effects like feeling sick, bloated, lightheadedness due to fasting before the test and the sudden intake of glucose. Some may also experience low blood sugar after the test.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 7 and 21 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My child was treated for a hormone-related condition before.
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My child takes medication that can change sugar or insulin levels, like steroids or Paxil.
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My BMI is below the 85th percentile for my age and gender.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline measurements
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline measurements for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Glucose Tolerance
Secondary study objectives
Insulin resistance
Other study objectives
Gene Expression

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Obese/overweight chldren/adolescentsExperimental Treatment1 Intervention
Obese or overweight children and adolescents between ages 7-21 that are at risk for developing type 2 diabetes will undergo an Oral Glucose Tolerance test (OGTT) to asses glucose status.
Group II: Lean children/adolescentsExperimental Treatment1 Intervention
Lean children/adolescents between the ages of 7-21. This cohort should have family members that have type 2 diabetes or was the result of a gestational diabetes pregnancy. They will undergo an Oral Glucose Tolerance Test to assess glucose status.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oral Glucose tolerance test
2015
N/A
~2520

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,912 Previous Clinical Trials
3,036,972 Total Patients Enrolled
60 Trials studying Obesity
246,110 Patients Enrolled for Obesity
National Institutes of Health (NIH)NIH
2,804 Previous Clinical Trials
8,146,758 Total Patients Enrolled
106 Trials studying Obesity
24,214 Patients Enrolled for Obesity
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
2,039 Previous Clinical Trials
2,668,942 Total Patients Enrolled
105 Trials studying Obesity
100,169 Patients Enrolled for Obesity

Media Library

Oral Glucose Tolerance Test (Diagnostic Test) Clinical Trial Eligibility Overview. Trial Name: NCT01967849 — N/A
Obesity Research Study Groups: Obese/overweight chldren/adolescents, Lean children/adolescents
Obesity Clinical Trial 2023: Oral Glucose Tolerance Test Highlights & Side Effects. Trial Name: NCT01967849 — N/A
Oral Glucose Tolerance Test (Diagnostic Test) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01967849 — N/A
~96 spots leftby Oct 2025