Popular Trials
Peripheral Vascular Stent
MicroStent for Peripheral Arterial Disease
This trial is testing a small tube-like device called the MicroStent® System, used along with a procedure that widens blood vessels, in patients with peripheral arterial disease who have blockages in the arteries below the knee. The stent helps keep the arteries open to ensure better blood flow. The Micro stent (MS) is a balloon expandable stent that allows the treatment of narrowings in distant and twisted coronary arteries.
Vasodilator
Beetroot Juice for Peripheral Arterial Disease
This trial will test whether short-term consumption of inorganic nitrate can improve blood flow responses, large artery hemodynamics, and leg oxygenation/exercise tolerance in patients with peripheral arterial disease.
Behavioural Intervention
Therapeutic Device for Peripheral Arterial Disease
This trial is testing a wearable device called the Vibrato Sleeve TUS, which uses sound waves to help improve blood flow in people with peripheral artery disease (PAD). Participants will use either the actual device or a non-functional version to see if it helps. The goal is to see if the device is safe and effective for improving leg circulation.
Drug Eluting Balloon
SELUTION SLR™ for Peripheral Arterial Disease
This trial tests a special balloon called SELUTION SLR™ DEB 014 for patients with severe leg artery blockages. The balloon helps open the artery and releases medicine to prevent it from getting blocked again.
Anticoagulant
Rivaroxaban + Aspirin for Peripheral Artery Disease
This trial is testing a drug that prevents blood clots in patients with poor blood flow in their arteries. The drug works by blocking a protein that helps blood to clot, which may improve their symptoms. When combined with aspirin, it has shown significant benefits in reducing deaths and heart-related problems in these patients.
Popular Filters
Trials for PAD Patients
Stent Graft
TORUS Stent Graft System for Peripheral Arterial Disease
This trial is testing a new stent graft system to see if it is safe and effective in treating atherosclerotic lesions in the native SFA or superficial femoral and/or proximal popliteal arteries.
Device
LimFlow System for Critical Limb Ischemia
This trial investigates the safety and effectiveness of the LimFlow System, a device that helps improve leg blood flow in patients with severe blood flow issues who can't be treated with usual treatments. It works by creating a new artery-to-vein connection below the knee to enhance circulation.
Behavioural Intervention
Exercise Programs for Knee Pain
This trial is testing a smartphone-based exercise program with coaching against the usual care given by doctors. It aims to help patients with peripheral artery disease who often struggle to follow exercise routines. The smartphone program could make it easier for them to stay on track and improve their health.
Trials for Peripheral Vascular Disease Patients
Device
LimFlow System for Critical Limb Ischemia
This trial investigates the safety and effectiveness of the LimFlow System, a device that helps improve leg blood flow in patients with severe blood flow issues who can't be treated with usual treatments. It works by creating a new artery-to-vein connection below the knee to enhance circulation.
Cell Therapy
Autologous Cell Therapy for Critical Limb Ischemia
This trial will test the feasibility of using a mix of cells enriched for endothelial progenitor cells and multipotent adult hematopoietic stem/progenitor cells to treat peripheral arterial disease and critical limb ischemia.
Behavioral Intervention
SMART Exercise for Peripheral Arterial Disease
This trial will address two barriers to exercise therapy in people with PAD to improve walking distance, reduce disability, and increase exercise tolerance. Participants will do either supervised treadmill exercise or home-based walking exercise with or without nitrate-rich beetroot juice.
Phase 3 Trials
Behavioral Intervention
SMART Exercise for Peripheral Arterial Disease
This trial will address two barriers to exercise therapy in people with PAD to improve walking distance, reduce disability, and increase exercise tolerance. Participants will do either supervised treadmill exercise or home-based walking exercise with or without nitrate-rich beetroot juice.
P2Y12 Inhibitor
Ticagrelor and HPR Screening for Peripheral Arterial Disease
This trial is testing whether screening for and intervening on patients with high on treatment platelet reactivity undergoing lower extremity arterial endovascular interventions can improve outcomes.
Anti-diabetic agent
Metformin for Peripheral Arterial Disease
This trial will test if taking metformin daily can help people with peripheral artery disease walk better by improving their blood flow and reducing inflammation. Metformin has been studied for its potential benefits in improving endothelial function and reducing inflammation in various conditions, including type 2 diabetes and peripheral artery disease.
Flavanols
Cocoa Flavanols for Peripheral Arterial Disease
This trial will test whether cocoa flavanols can improve peripheral artery disease by measuring six-minute walk distance, Actigraph-measured physical activity, brachial artery flow-mediated dilation (FMD), gastrocnemius muscle biopsy measures of endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS, gastrocnemius muscle perfusion (measured by magnetic resonance imaging (MRI)) and gastrocnemius muscle characteristics (measured by muscle biopsy).
Trials With No Placebo
Stent Graft
TORUS Stent Graft System for Peripheral Arterial Disease
This trial is testing a new stent graft system to see if it is safe and effective in treating atherosclerotic lesions in the native SFA or superficial femoral and/or proximal popliteal arteries.
Device
LimFlow System for Critical Limb Ischemia
This trial investigates the safety and effectiveness of the LimFlow System, a device that helps improve leg blood flow in patients with severe blood flow issues who can't be treated with usual treatments. It works by creating a new artery-to-vein connection below the knee to enhance circulation.
Behavioural Intervention
Exercise Programs for Knee Pain
This trial is testing a smartphone-based exercise program with coaching against the usual care given by doctors. It aims to help patients with peripheral artery disease who often struggle to follow exercise routines. The smartphone program could make it easier for them to stay on track and improve their health.
View More Related Trials
Frequently Asked Questions
Introduction to pad
What are the top hospitals conducting pad research?
Peripheral artery disease (PAD) affects millions of people worldwide, causing narrowing or blockage in the blood vessels that supply the legs and feet. In our quest for innovative treatments, several leading hospitals have emerged as beacons of hope in the field of PAD clinical trials. Boston’s Massachusetts General Hospital takes a prominent role with six active trials focused on PAD and a cumulative record of 11 studies conducted since their first recorded trial back in 2005. Similarly, Northwestern University in Chicago stands tall with six ongoing PAD trials and an impressive total of 17 previously completed investigations since they embarked on this journey in 2006.
Making strides alongside these renowned institutions is the University of Chicago, which currently conducts five active clinical trials for patients suffering from PAD. Since initiating their pioneering trial in 2001, they have amassed eight additional studies aimed at finding breakthroughs to improve outcomes for those affected by this condition. Meanwhile, at the University of Minnesota located in Minneapolis, researchers are pursuing five ongoing PAD trials while building upon their experience from eleven already completed investigations since entering this realm back in 2009.
Lastly but certainly not least, we turn our attention to Charlottesville's esteemed University of Virginia where four current clinical trials addressing peripheral artery disease offer promise for cutting-edge advancements. Although relatively recent entrants into this area with their initial recorded trial occurring only ten years ago -in2010-, they have already contributed nine valuable studies towards expanding our understanding and treatment options when it comes to alleviating suffering caused by narrowed leg arteries.
With each research endeavor undertaken by these top hospitals across various locations nationwide comes renewed hope for individuals grappling with PAD—a collective effort dedicated to improving quality-of-life outcomes through groundbreaking discoveries. The passion and commitment displayed within these medical institutions pave the way toward a future where new treatments hold potential to transform countless lives impacted by peripheral artery disease
Which are the best cities for pad clinical trials?
In the realm of clinical trials for peripheral arterial disease (PAD), several cities emerge as hotspots for cutting-edge research. Chicago, Illinois leads the pack with 16 active trials investigating interventions like supervised treadmill exercise combined with nitrate-rich beetroot juice and Metformin. Boston, Massachusetts follows closely behind with 11 ongoing studies focused on innovative technologies such as the LimFlow System and Surmodics SurVeil DCB. New york, New York also shines in this field with 10 active trials exploring treatments like Intravascular Lithotripsy and PQ Bypass System. Raleigh, North carolina and Gainesville, Florida round out the list with their own contributions to PAD research. These cities offer individuals affected by PAD access to promising clinical trials that may advance our understanding of this condition and pave the way for improved treatment options.
Which are the top treatments for pad being explored in clinical trials?
Clinical trials for peripheral artery disease (PAD) are exploring various treatments that show promise in combating this condition. The PQ Bypass System, introduced in 2017, is currently being evaluated in two active trials focused on PAD. Additionally, exercise has emerged as a potential treatment option and is the subject of two ongoing clinical trials. With a total of eleven all-time PAD trials since its first listing in 2003, exercise remains an area of interest for researchers seeking effective interventions against this debilitating disease.
What are the most recent clinical trials for pad?
Recent clinical trials have shed light on potential breakthroughs in the treatment of peripheral artery disease (PAD). One notable study investigated the efficacy of supervised treadmill exercise combined with nitrate-rich beetroot juice, offering a novel approach to managing this condition. Another trial focused on the use of liposomal bupivacaine as a promising intervention for PAD patients. Additionally, carnosine has shown promise in early-stage research, indicating its potential benefits for individuals affected by PAD. Moreover, heat therapy and rivaroxaban 2.5 mg oral tablet have also been explored as possible avenues for improving outcomes in patients diagnosed with PAD. These ongoing studies hold great promise for enhancing treatments and quality of life among those living with this debilitating vascular disorder.
What pad clinical trials were recently completed?
Recently completed clinical trials have made significant progress in the field of peripheral artery disease (PAD). In May 2020, Alucent Biomedical concluded a trial investigating the potential of NVS Therapy to treat this condition. Around the same time, Florida State University successfully completed a trial exploring the use of Creatine monohydrate as a therapy for PAD. Although slightly older, an additional noteworthy study was conducted by the University of Virginia and finished in July 2017, which examined Alirocumab's efficacy for PAD treatment. These advancements underscore ongoing efforts to find innovative solutions that can improve outcomes for individuals battling PAD.