Device
HD-tDCS + mCILT for Primary Progressive Aphasia
This trial is testing whether high-definition transcranial direct current stimulation (HD-tDCS) paired with modified constraint-induced language therapy (mCILT) can improve language performance in people with primary progressive aphasia (PPA). The study will compare changes in language performance and brain imaging before and after receiving 10 semi-consecutive daily sessions of real or sham HD-tDCS + mCILT. The 3-month follow-up will be the primary endpoint.
Behavioural Intervention
Multicomponent Language Treatment for Primary Progressive Aphasia
This trial aims to help individuals with Primary Progressive Aphasia (PPA), a condition that causes a gradual decline in communication skills due to brain degeneration. The researchers want to test a new treatment approach
Procedure
Speech Therapy + tDCS for Aphasia
This trial aims to help people with primary progressive aphasia (PPA) by combining home-based brain stimulation with online speech therapy. The brain stimulation uses a gentle electrical current to boost the effects of speech therapy, which may improve communication skills and quality of life for those affected by PPA.
Popular Filters
Trials for PPA Patients
Behavioural Intervention
Speech-Language Therapy for Primary Progressive Aphasia
This trial seeks to study how tailored speech-language interventions help bilingual individuals with PPA. Researchers will evaluate effects of treatment, language use, and brain scans to determine best approach.
Behavioural Intervention
tDCS + Language Therapy for Primary Progressive Aphasia
This trial uses a gentle electrical current applied to the scalp to help patients with Primary Progressive Aphasia improve their language abilities. The treatment stimulates specific brain areas, helping the brain reorganize around damaged regions. This method has shown promise in improving language symptoms in patients with primary progressive aphasia and post-stroke aphasia.
Behavioural Intervention
Speech and Language Therapy for Primary Progressive Aphasia
This trial tests speech-language therapy for adults with primary progressive aphasia (PPA), a condition that impairs communication. The therapy aims to improve speech and language abilities by using targeted exercises. Researchers will track participants over time to see if the therapy helps slow down the decline in communication skills.
Trials for Frontotemporal Dementia Patients
Behavioural Intervention
Speech-Language Therapy for Primary Progressive Aphasia
This trial seeks to study how tailored speech-language interventions help bilingual individuals with PPA. Researchers will evaluate effects of treatment, language use, and brain scans to determine best approach.
Tau PET Imaging for Frontotemporal Dementia
This trial uses a drug called AV-1451 to study its ability to bind to tau proteins in the brains of patients with PPA and FTD. By doing this, researchers hope to better understand tau buildup in these conditions.
Hormone Therapy
Oxytocin Nasal Spray for Frontotemporal Dementia
This trial is testing the safety and effects of oxytocin given as a nasal spray to people with frontotemporal dementia or Pick's disease, compared to a placebo. Approximately 112 patients will be enrolled at 15 centers in the US and Canada, and will be given either oxytocin or the placebo nasal spray. The trial will happen in two phases, first testing different doses of oxytocin to see which is most effective, and then randomly assigning patients in the second phase to either the most effective dose of oxytocin or the placebo.
Retinal Imaging for Neurodegenerative Disease
This trial uses special cameras to take detailed pictures of the back of the eye in people with cognitive impairments or neurodegenerative diseases. Researchers analyze these images to find early signs of these diseases by examining tiny blood vessels in the eye.
Trials With No Placebo
Behavioural Intervention
Speech-Language Therapy for Primary Progressive Aphasia
This trial seeks to study how tailored speech-language interventions help bilingual individuals with PPA. Researchers will evaluate effects of treatment, language use, and brain scans to determine best approach.
Behavioural Intervention
Speech and Language Therapy for Primary Progressive Aphasia
This trial tests speech-language therapy for adults with primary progressive aphasia (PPA), a condition that impairs communication. The therapy aims to improve speech and language abilities by using targeted exercises. Researchers will track participants over time to see if the therapy helps slow down the decline in communication skills.
Tau PET Imaging for Frontotemporal Dementia
This trial uses a drug called AV-1451 to study its ability to bind to tau proteins in the brains of patients with PPA and FTD. By doing this, researchers hope to better understand tau buildup in these conditions.
View More Related Trials
Frequently Asked Questions
Introduction to primary progressive aphasia
What are the top hospitals conducting primary progressive aphasia research?
When it comes to advancing our understanding of primary progressive aphasia, several top hospitals are leading the way in conducting clinical trials. In Baltimore, Johns Hopkins Hospital is at the forefront with four ongoing trials focused on this rare neurological condition characterized by a progressive loss of language abilities. With their first recorded trial in 2023, they are committed to exploring innovative approaches and potential treatments for primary progressive aphasia. Similarly, the University of Pennsylvania in Philadelphia has three active trials dedicated to studying this disorder that affects communication skills. They too began their journey into primary progressive aphasia research in 2023.
Meanwhile, the University of Texas in Austin has taken up the challenge with two ongoing trials since recording their first study back in 2017. Their efforts contribute immensely to unraveling the complexities surrounding primary progressive aphasia and offer hope for future interventions. Mayo Clinic located in Rochester also plays a significant role with two currently running trials as part of their extensive experience which dates back to 2010 when they began investigating this enigmatic condition.
Notably, among these distinguished institutions stands out Memory and Aging Center at the University of California, San Francisco where researchers are actively conducting one trial targeting primary progressive aphasia—a testament to their commitment towards unravelling mysteries within neurodegenerative diseases like these; although yet untouched territory concerning PPA's progressional treatment options—new doors open through each investigation conducted here.
These renowned hospitals across different regions demonstrate unwavering dedication toward making breakthroughs that could potentially benefit individuals living with primary progressive aphasia and improve their quality of life significantly. Through collaborative efforts such as these clinical trials conducted nationwide, we inch ever closer towards better comprehension and potentially life-changing therapeutic solutions for those affected by this challenging condition.
Which are the best cities for primary progressive aphasia clinical trials?
When it comes to primary progressive aphasia clinical trials, several cities are at the forefront of research. Baltimore, Maryland offers 5 active studies exploring treatments like Active tDCS + Language Therapy and High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment. Austin, Texas has 3 ongoing trials focusing on interventions such as RS-LRT and Video-Implemented Script Training for Aphasia (VISTA). Philadelphia, Pennsylvania also hosts 3 active trials investigating options like Active tDCS + Language Therapy and HD-tDCS+mCILT. San Francisco, California and Rochester, Minnesota each have 2 studies underway examining approaches including RS-LRT and F-18 AV 1451. These cities provide patients with primary progressive aphasia access to cutting-edge research that may lead to improved treatment outcomes.
Which are the top treatments for primary progressive aphasia being explored in clinical trials?
Clinical trials are actively exploring novel treatments for primary progressive aphasia. One promising approach involves the combination of active transcranial direct current stimulation (tdcs) with language therapy, currently being evaluated in a single ongoing trial since 2023. Another innovative treatment under investigation is Video-Implemented Script Training for Aphasia (VISTA), which utilizes video-based techniques to aid individuals with aphasia. This intervention is also being studied in one active trial and was first listed in 2017. These pioneering treatments offer hope for individuals living with primary progressive aphasia and may potentially improve their quality of life through enhanced communication abilities.
What are the most recent clinical trials for primary progressive aphasia?
In the realm of primary progressive aphasia, recent clinical trials have sparked hope for novel treatment approaches. One such trial involves remotely supervised tdcs and word-naming practice, which has entered Phase 2 as of November 1st, 2022. Another study explores the potential benefits of HD-tDCS+mCILT in individuals with primary progressive aphasia, also currently in Phase 2 since August 17th, 2020. Additionally, AV-1451 is being investigated in a Phase 4 trial that began on July 1st, 2018. These pioneering efforts offer promising prospects towards improving the lives of those affected by this challenging condition.
What primary progressive aphasia clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the field of primary progressive aphasia. These trials focused on evaluating novel treatments and therapies to address this specific neurodegenerative disorder. While details may vary, three noteworthy studies were recently concluded. With promising results, these trials offer hope for individuals affected by primary progressive aphasia and their loved ones as researchers continue to explore innovative approaches to manage and potentially halt its progression.