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HIIT Exercise for Endometrial Cancer
N/A
Waitlist Available
Led By Victoria Bae-Jump, MD
Research Sponsored by UNC Lineberger Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients with a diagnosis of endometrial cancer who are to undergo hysterectomy and staging
Endometrioid histology endometrial cancer
Must not have
Severely impaired hearing or speech
Inability to speak English
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing whether high-intensity interval training (HIIT) can help fight endometrial cancer.
Who is the study for?
Women aged 40-75 with endometrial cancer, scheduled for surgery, and a BMI of 30-50 kg/m2 can join. They must have early-stage disease, access to email and a smartphone, and be able to visit the lab for tests. Those with recent severe cardiovascular events, other interventions or conditions that limit safe participation are excluded.
What is being tested?
The trial studies the effects of high intensity interval training (HIIT) on women with endometrial cancer before their standard surgery. It aims to see if HIIT has anti-cancer benefits by examining changes in tissue and blood markers.
What are the potential side effects?
While not drug-related, side effects from HIIT may include muscle soreness, fatigue, increased heart rate during exercise, risk of injury if not performed correctly, and possible exacerbation of pre-existing health conditions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have endometrial cancer and am scheduled for a hysterectomy and staging.
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My cancer is a type of endometrial cancer called endometrioid.
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I am between 40 and 75 years old.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have severe hearing or speech impairments.
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I cannot speak English.
Select...
I have not been hospitalized for stroke, heart attack, or heart failure, nor had surgery for blocked arteries in the last 3 months.
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I have severe dementia or significant memory loss.
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I use insulin to manage my diabetes.
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I have a condition that limits my physical activity.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in proliferative markers in endometrium before and after HIIT exercises
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: HIIT exerciseExperimental Treatment1 Intervention
Participants will perform HIIT exercises as instructed by the study team in the weeks prior to standard of care surgery
Find a Location
Who is running the clinical trial?
UNC Lineberger Comprehensive Cancer CenterLead Sponsor
363 Previous Clinical Trials
91,976 Total Patients Enrolled
8 Trials studying Endometrial Cancer
211 Patients Enrolled for Endometrial Cancer
National Cancer Institute (NCI)NIH
13,925 Previous Clinical Trials
41,017,969 Total Patients Enrolled
73 Trials studying Endometrial Cancer
73,262 Patients Enrolled for Endometrial Cancer
Victoria Bae-Jump, MDPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
1 Previous Clinical Trials
3 Total Patients Enrolled
1 Trials studying Endometrial Cancer
3 Patients Enrolled for Endometrial Cancer
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Eligibility Criteria:
This trial includes the following eligibility criteria:- Your body mass index (BMI) is between 30 and 50, which means you may be overweight or have obesity.I agree to visit the lab for baseline testing within 2 days if it can't be done the same day as my standard of care visit.I have access to email.I agree to follow-up visits 2 weeks after surgery, with a 2-week flexibility.I have endometrial cancer and am scheduled for a hysterectomy and staging.I have severe hearing or speech impairments.You have a serious mental health condition.You currently have a mental illness called psychosis or you are dealing with substance abuse problems that are not under control.I cannot speak English.I have not been hospitalized for stroke, heart attack, or heart failure, nor had surgery for blocked arteries in the last 3 months.My cancer is a type of endometrial cancer called endometrioid.I have severe dementia or significant memory loss.I use insulin to manage my diabetes.I am between 40 and 75 years old.My cancer is believed to be in the early stage and confined to my uterus.I have a condition that limits my physical activity.You engage in physical activity for at least 150 minutes per week, following the guidelines set by the American College of Sports Medicine.You are currently doing high-intensity interval training (HIIT) workouts.
Research Study Groups:
This trial has the following groups:- Group 1: HIIT exercise
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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