Trial Summary
What is the purpose of this trial?This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery. The goal is to analyze this fluid for inflammatory markers that can potentially help identify new strategies in the future to control seizures in individuals with epilepsy who fail to respond to currently available drugs.
Eligibility Criteria
This trial is for individuals with epilepsy who haven't improved after trying at least two different anti-seizure medications. They should have a normal MRI scan and not be on immune-modifying treatments, have autoimmune disorders, infections, or cancer-related health issues.Inclusion Criteria
I have tried at least two different seizure medications without success.
Your MRI scan shows no abnormalities.
Exclusion Criteria
You have another cancer-related health condition.
You have an autoimmune disorder.
I am showing signs of having another infection.
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Participant Groups
The study involves collecting and analyzing fluid from the brain during epilepsy surgery to look for inflammation markers. This could lead to new seizure control methods for drug-resistant epilepsy in the future.
1Treatment groups
Experimental Treatment
Group I: drug-resistant temporal lobe epilepsyExperimental Treatment1 Intervention
Our current standard practice is to use a lateral approach through the middle temporal gyrus to place 3 depth electrodes targeting the hippocampus for intraoperative verification of pathological epileptiform activity prior to resection. Our research protocol will add one FDA approved electrode that has a central cannula for insertion of a microdialysis probe. The electro-physiological data that will be gathered is not altered and this methodology will not impact standard clinical care, except and will not to extend the duration in the OR - the measurements will occur during the clinical electrocorticography (ECoG; intracranial electroencephalography (iEEG)) procedure by 15 min.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Mayo Clinic in RochesterRochester, MN
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Who Is Running the Clinical Trial?
Mayo ClinicLead Sponsor