Smart Underwear for Gastrointestinal Microbiome

Recruiting in Palo Alto (17 mi)

Overseen by Noel T Mueller, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Colorado, Denver

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.

Eligibility Criteria

This trial is for individuals interested in helping test a Smart Underwear device that measures changes in gut hydrogen sulfide production due to diet. Participants will follow two different diets, one high and one low in cysteine, to see how it affects their gastrointestinal microbiome.

Inclusion Criteria

Willing to complete the entire study protocol, i.e. eating all of the food that is provided and completing all required measurements.

Willing to discuss flatus

I am generally healthy with no major illnesses.

Exclusion Criteria

Food preferences, intolerance, or dietary requirements that would interfere with diet adherence

Planned dietary changes during the study period

Lack of appropriate food refrigeration and preparation equipment (e.g.- oven or microwave)

Participant Groups

The study tests the effectiveness of Smart Underwear in detecting diet-induced shifts in gut microbial hydrogen sulfide levels. It involves a crossover design where participants alternate between high and low cysteine diets over separate periods with a break in between.

Group I: Low Cysteine Diet Experimental Treatment 1 Intervention

A dietary pattern designed to have a low level of dietary cysteine

Group II: High Cysteine Diet Active Control 1 Intervention

A dietary pattern designed to have a high level of dietary cysteine

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

University of Colorado Anschutz Medical Campus Aurora, CO

Who Is Running the Clinical Trial?

University of Colorado, Denver Lead Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Collaborator

University of Maryland, College Park Collaborator

References