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Proton Beam Therapy

Proton Radiation for Brain Tumors

N/A
Waitlist Available
Led By Helen A Shih, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 years
Awards & highlights
No Placebo-Only Group

Summary

"This trial is studying proton radiation to see if it can effectively treat brain tumors with fewer side effects compared to traditional radiation therapy."

Who is the study for?
This trial is for people with specific brain tumors called low-grade gliomas or Grade III anaplastic glioma, which have certain genetic features. Participants must need radiation therapy, be expected to live more than 5 years, speak English, and be able to undergo MRI scans and cognitive tests.
What is being tested?
The study is testing proton radiation therapy to see if it can control tumor growth as effectively as photon therapy while reducing side effects. Proton radiation aims to spare healthy tissue from exposure unlike conventional therapies.
What are the potential side effects?
While the goal of proton radiation is fewer side effects compared to traditional treatments, potential risks may include skin reactions at the treatment site, fatigue, headaches, hair loss near treated areas and temporary swelling.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Efficacy
Secondary study objectives
Overall survival
Safety and Tolerability

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Proton radiation therapyExperimental Treatment1 Intervention
Single arm study delivering fractionated proton therapy over 6 week (54-59.4 Gy(RBE))
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Proton radiation
2011
Completed Phase 2
~20

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,924 Previous Clinical Trials
41,017,888 Total Patients Enrolled
Massachusetts General HospitalLead Sponsor
3,013 Previous Clinical Trials
13,309,248 Total Patients Enrolled
Helen A Shih, MDPrincipal InvestigatorMassachusetts General Hospital
3 Previous Clinical Trials
204 Total Patients Enrolled
~2 spots leftby May 2025
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