MR Spectroscopy for Brain Tumor
Trial Summary
What is the purpose of this trial?
Background: Glioma is a type of brain cancer. Some of these tumors have gene mutations. These mutations can cause a substance called 2-HG to build up in the brain. This makes the tumors more aggressive. Researchers want to better understand 2-HG buildup in the brain. They hope this can help them design better ways to test for gliomas. Objective: To monitor the level of 2-HG in the brains of people with gliomas that have mutations in the IDH1 or IDH2 genes. Eligibility: People ages 18 and older with gliomas with mutations in the IDH1 or IDH2 genes Design: Participants will be screened with: Medical and cancer history Physical exam Reviews of their symptoms and ability to perform normal activities Blood and urine tests MRI scan Samples of their tumor from a past surgery Documentation of their diagnosis and mutation status Participants will have an initial evaluation. This will include repeats of screening tests. It will also include: Neurological exam MRS and MRI scans of the brain: Participants will lie on a table that slides into a metal cylinder. A coil or soft padding will be placed around their head. They will have a contrast agent injected into a vein. Pictures will be taken of the brain. Participants will have follow-up visits every 2-6 month for the rest of their life. Visits will include scans. ...
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment MRS and MRI scans of the brain, AG-881, for brain tumors?
MR spectroscopy (MRS) can help in identifying active and microscopic disease in brain tumors, which MRI alone might miss, and it can also differentiate between tumor types and assess treatment outcomes. This suggests that MRS, as part of the treatment, could improve the accuracy of diagnosing and monitoring brain tumors.12345
Is MR Spectroscopy safe for humans?
How does MR Spectroscopy differ from other treatments for brain tumors?
MR Spectroscopy is unique because it is a non-invasive imaging technique that analyzes the chemical composition of brain tumors, helping to distinguish between different types and grades of tumors. Unlike traditional treatments that focus on removing or shrinking tumors, MR Spectroscopy provides detailed metabolic information that can guide diagnosis and treatment planning.310111213
Research Team
Jing Wu, M.D.
Principal Investigator
National Cancer Institute (NCI)
Eligibility Criteria
This trial is for adults with gliomas (a type of brain cancer) that have specific mutations called IDH1 or IDH2. Participants must be over 18, able to perform daily activities at a reasonable level, and have normal kidney function. Pregnant women and individuals with conditions that could affect the study are excluded.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Initial Evaluation
Participants undergo neurological exam, MRS and MRI scans of the brain, and repeat screening tests
Longitudinal Monitoring
Participants have follow-up visits every 2-6 months for the rest of their life, including scans to monitor 2-HG levels
Follow-up
Participants are monitored for safety and effectiveness after initial evaluation and during ongoing monitoring
Treatment Details
Interventions
- MRS and MRI scans of the brain (MR Spectroscopy)
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Cancer Institute (NCI)
Lead Sponsor