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Electrolyte Beverage

Fluid Loading for Healthy Subjects

N/A
Recruiting
Led By Jason R. Lytle, PhD
Research Sponsored by National Aeronautics and Space Administration (NASA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Pass a NASA Johnson Space Center (JSC) Test Subject Screening (TSS) Facility modified Air Force Class III physical.
Be between 18 and 65 years old
Must not have
Type II Diabetes
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8-9 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to understand how drinking different fluids affects the volume of blood and plasma in healthy participants throughout the day. Participants will drink water, water with salt tablets, or a saltier electrolyte beverage

Who is the study for?
This trial is for healthy individuals interested in how blood and plasma volumes change during the day. Participants will need to visit the study site four times, drinking water alone on one visit and water with salt tablets or an electrolyte solution on others.
What is being tested?
The study tests how blood volume changes when 'fluid loading' with different solutions: plain water, water plus salt tablets, and a salty electrolyte beverage. It aims to mimic astronaut fluid intake on landing day over approximately nine hours.
What are the potential side effects?
Potential side effects may include discomfort from excess fluid intake such as bloating, increased urination, or mild gastrointestinal issues due to the high salt content in tablets and the electrolyte solution.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I passed a special health and fitness exam for a NASA study.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have Type II Diabetes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8-9 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8-9 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Fluid Balance
Gastrointestinal Distress
Plasma Volume
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Water plus Salt TabletsExperimental Treatment1 Intervention
A typical water and meal schedule will be followed, with the addition of Fluid Loading water plus salt tablets.
Group II: Electrolyte Solution over 4 hoursExperimental Treatment1 Intervention
A typical water and meal schedule will be followed, with the addition of Fluid Loading electrolyte solution over 4 hours.
Group III: Electrolyte Solution Single BolusExperimental Treatment1 Intervention
A typical water and meal schedule will be followed, with the addition of Fluid Loading electrolyte solution single bolus.
Group IV: ControlActive Control1 Intervention
A typical water and meal schedule will be followed on the Control day.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Electrolyte Solution
2014
N/A
~20

Find a Location

Who is running the clinical trial?

National Aeronautics and Space Administration (NASA)Lead Sponsor
30 Previous Clinical Trials
1,863 Total Patients Enrolled
Jason R. Lytle, PhDPrincipal InvestigatorNational Aeronautics and Space Administration (NASA)
~4 spots leftby Oct 2025
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