Complement Inhibitor
Danicopan for Age-Related Macular Degeneration
This trial is testing a medication called danicopan to see if it can help people with a specific type of eye disease called Geographic Atrophy, which is related to Age-related Macular Degeneration. The study will check how well the medication works, how safe it is, and how the body handles it.
Stem Cell Therapy
Stem Cell Transplant for Age-Related Macular Degeneration
This trial is testing if it is safe to put cells in people's eyes as a possible future treatment for dry age-related macular degeneration. People who have had "wet" macular degeneration in either eye are not eligible.
Procedure
OcuMet Beacon for Age-Related Macular Degeneration
This trial aims to see if stressed cells in the retina match up with areas of disease seen in standard imaging and if these images can help identify potential problem areas before symptoms appear. The main focus is on
Popular Filters
Trials for Age-Related Macular Degeneration Patients
Gene Therapy
OCU410 for Age-Related Macular Degeneration
This trial tests OCU410, a gene therapy injected into the eye, for patients with severe vision loss due to advanced dry AMD. The treatment uses a virus to deliver helpful genes that may restore normal eye function.
Procedure
Tinlarebant for Age-Related Macular Degeneration
This trial is testing a new pill called tinlarebant in people with Geographic Atrophy, an eye condition that causes vision loss. The goal is to see if the pill can help slow down or stop the progression of the disease.
Virus Therapy
JNJ-81201887 for Geographic Atrophy Due to Age-Related Macular Degeneration
This trial is testing a new treatment called JNJ-81201887 to see if it can slow down the growth of damaged areas in the eyes of people with geographic atrophy. This condition causes parts of the retina to deteriorate, and the treatment aims to protect the retina and preserve vision.
Stem Cell Therapy
OpRegen for Age-Related Macular Degeneration
This trial is testing OpRegen, a cell injection treatment, in patients with severe vision loss due to age-related macular degeneration. The goal is to see if injecting these cells under the retina can help repair or support damaged eye cells.
Trials for AMD Patients
Gene Therapy
OCU410 for Age-Related Macular Degeneration
This trial tests OCU410, a gene therapy injected into the eye, for patients with severe vision loss due to advanced dry AMD. The treatment uses a virus to deliver helpful genes that may restore normal eye function.
Procedure
Tinlarebant for Age-Related Macular Degeneration
This trial is testing a new pill called tinlarebant in people with Geographic Atrophy, an eye condition that causes vision loss. The goal is to see if the pill can help slow down or stop the progression of the disease.
Virus Therapy
JNJ-81201887 for Geographic Atrophy Due to Age-Related Macular Degeneration
This trial is testing a new treatment called JNJ-81201887 to see if it can slow down the growth of damaged areas in the eyes of people with geographic atrophy. This condition causes parts of the retina to deteriorate, and the treatment aims to protect the retina and preserve vision.
Stem Cell Therapy
OpRegen for Age-Related Macular Degeneration
This trial is testing OpRegen, a cell injection treatment, in patients with severe vision loss due to age-related macular degeneration. The goal is to see if injecting these cells under the retina can help repair or support damaged eye cells.
Trials With No Placebo
Gene Therapy
OCU410 for Age-Related Macular Degeneration
This trial tests OCU410, a gene therapy injected into the eye, for patients with severe vision loss due to advanced dry AMD. The treatment uses a virus to deliver helpful genes that may restore normal eye function.
Stem Cell Therapy
OpRegen for Age-Related Macular Degeneration
This trial is testing OpRegen, a cell injection treatment, in patients with severe vision loss due to age-related macular degeneration. The goal is to see if injecting these cells under the retina can help repair or support damaged eye cells.
Device
SING-IMT for Late-Stage Age-Related Macular Degeneration
This trial tests a tiny telescope implanted in the eye to help people with severe vision loss from late-stage AMD. The telescope magnifies images to improve vision by using healthy parts of the eye.
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Frequently Asked Questions
Introduction to geographic atrophy
What are the top hospitals conducting geographic atrophy research?
When it comes to cutting-edge clinical trials in the field of geographic atrophy, several hospitals have emerged as leaders. In Hagerstown, Maryland, Cumberland Valley Retina Consultants is making significant strides with four active trials focused on this condition. With a history of six completed geographic atrophy trials and their first recorded trial dating back to 2019, this hospital's dedication to advancing knowledge and treatment options for patients is commendable. Similarly, East Florida Eye Institute in Stuart has also embraced the challenge with four ongoing clinical trials specifically targeting geographic atrophy. Since their inaugural trial in 2018, they have conducted a total of six studies dedicated to understanding and combating this degenerative eye disease.
In Bellaire, Texas, Retina Consultants of Texas stands out as another leading institution committed to uncovering breakthroughs in the understanding and treatment of geographic atrophy. With four active clinical trials currently underway and a noteworthy seven completed studies since their first recorded trial in 2019, their contributions are invaluable to both patients and researchers alike. Meanwhile, on the West Coast in Poway near San Diego lies Retina Consultants San Diego - an establishment renowned for its dedication towards tackling geographic atrophy through three ongoing clinical investigations along with eight previously conducted ones since launching its first study back in 2018.
Finally yet importantly based out Walnut Creek California Bay Area Retina Associates plays its part by actively conducting three current Geographic Atropy research programs while being affiliated with eight comparative previous scientific efforts from advantageous location holding many years worth medical wisdom; starting off way back around year 2014.
These esteemed institutions demonstrate that when it comes to researching geographic atrophy – a progressive degeneration of retinal tissue leading to vision loss – innovative minds across various locations are working diligently toward finding solutions. Through these collaborative efforts between healthcare professionals and dedicated participants who enroll in these groundbreaking studies we can aspire towards mitigating suffering caused by such eyesight threatening conditions ultimately paving ways towards brighter and clearer future for those affected by geographic atrophy.
Which are the best cities for geographic atrophy clinical trials?
Hagerstown, Maryland; Dallas, Texas; Phoenix, Arizona; Cleveland, Ohio; and San Antonio, Texas are among the best cities for geographic atrophy clinical trials. These cities offer individuals access to a variety of active trials focused on finding effective treatments for this condition. With 10 active trials each in Hagerstown and Dallas studying ANX007, PEGCETACOPLAN (APL-2), LBS-008, Tinlarebant, Avacincaptad pegol 2 mg intravitreal injection and more. Meanwhile Phoenix and Cleveland have 9 active trials exploring IONIS-FB-LRx and Danicopan alongside others. San Antonio also contributes to research with 8 active studies investigating Arm B: JNJ-81201887 High dose along with ANX007 and PEGCETACOPLAN (APL-2). These cities serve as hubs for innovative research that brings hope to those affected by geographic atrophy.
Which are the top treatments for geographic atrophy being explored in clinical trials?
Exciting developments are taking place in the realm of geographic atrophy, with clinical trials exploring potential treatments. OpRegen takes center stage with one active trial and being the first listed treatment for geographic atrophy in 2023. Another promising contender is Avacincaptad pegol, offering hope through its intravitreal injection method. With one active trial and a first listing in 2022, it shows great potential to address this condition. These ongoing trials bring optimism for patients battling geographic atrophy as researchers work towards breakthrough solutions.
What are the most recent clinical trials for geographic atrophy?
Exciting advancements are being made in the field of geographic atrophy, with several recent clinical trials offering hope for patients. Among these trials is a Phase 1/2 study evaluating the efficacy and safety of low-dose administration for geographic atrophy treatment. Another promising trial involves LBS-008, Tinlarebant, which has entered Phase 3 testing to assess its potential benefits in combating this condition. Additionally, CT1812 is undergoing a Phase 2 trial involving the use of a 200 mg dose specifically targeted towards geographic atrophy patients. Other ongoing studies include Part 1 and OpRegen, both in Phase 2 stages and showing promise as potential treatments for this debilitating disease. These latest clinical trials hold tremendous potential for improving outcomes and quality of life for those affected by geographic atrophy.
What geographic atrophy clinical trials were recently completed?
Several significant clinical trials investigating treatments for geographic atrophy have recently been completed, showcasing advancements in this field. In December 2020, a trial sponsored by Hoffmann-La Roche successfully concluded their study on RO7303359. Another noteworthy trial sponsored by NGM Biopharmaceuticals, Inc., testing the effectiveness of NGM621 reached completion in July 2020. Meanwhile, Stealth BioTherapeutics Inc.'s investigation into Subcutaneous elamipretide through the elamipretide delivery system was finalized in March 2019. Notably, Apellis Pharmaceuticals, Inc. conducted two separate trials on APL-2 that were both finished in August 2018 and University of California San Francisco explored Metformin's potential as a treatment for geographic atrophy before concluding their research in April 2016. These extensive efforts highlight the growing dedication to finding effective therapies for individuals affected by this condition.