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Procedure

Transcranial Magnetic Stimulation for Brain Network Targeting (NetworkTMS Trial)

N/A

Waitlist Available

Research Sponsored by Brigham and Women's Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age greater than 18 and less than 65 years

No prior neuropsychiatric, neurological disorders, epilepsy, or seizures

Must not have

Vascular clips in the head or previous neurosurgery

Failure to perform the task of lying still

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 to 15 minutes right before and after each tms session

Summary

This trial aims to develop a method for precisely targeting and stimulating specific brain networks using magnetic stimulation and MRI data. Participants will have two visits, where their brain will be scanned with MRI in the first visit

Who is the study for?

This clinical trial is for healthy volunteers interested in contributing to research on brain stimulation. Participants will undergo MRI scans and TMS sessions while completing tasks, with the aim of improving response times and accuracy.

What is being tested?

The study tests a new method for targeting brain networks using Transcranial Magnetic Stimulation (TMS) guided by MRI data. It involves two visits: one for MRI scanning and another for four TMS sessions with EEG monitoring during task performance.

What are the potential side effects?

TMS may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in rare cases. EEG is non-invasive but might cause mild skin irritation from electrode placement.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 19 and 64 years old.

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I have never had epilepsy, seizures, or serious brain disorders.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had brain surgery or have metal clips in my head.

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I cannot stay still when required.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 to 15 minutes right before and after each tms session

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 to 15 minutes right before and after each tms session

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 to 15 minutes right before and after each tms session for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

choice reaction time (CRT)

Secondary study objectives

response error

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Transcranial Magnetic StimulationExperimental Treatment1 Intervention

TMS with the intermittent theta burst stimulation protocol will be applied to the computed brain targets based on the MRI data of each participants.

Group II: Sham Transcranial Magnetic StimulationPlacebo Group1 Intervention

Sham TMS coils will be applied to stimulate the brain targets. No magnetic field will be generated using the sham coil. It will play sounds similar to the true TMS stimulations with the pulsed weak electric current applied to the scalp to generate a similar feeling as in true stimulations.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Transcranial Magnetic Stimulation Device

2019

N/A

~80

0 / 4Eligibility criteria met