Transcranial Magnetic Stimulation for Brain Network Targeting
(NetworkTMS Trial)

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Brigham and Women's Hospital

No Placebo Group

Approved in 3 Jurisdictions

Trial Summary

What is the purpose of this trial?The goal of this study is to develop and validate an approach for accurate targeting and stimulation of brain networks using transcranial magnetic stimulation (TMS) using information from magnetic resonance imaging (MRI) data. This study requires two visits from each participant. In the first visit, the participant will be scanned by MRI scanners to collect data from the brain. Next, the data will be analyzed by the researcher to model the connections between different regions of the brain to determine the stimulation areas related to the so-called frontoparietal network. In the second visit, the participants will take four TMS sessions with different types of stimulations applied to the computed targets and complete a computer-based task named multi-source interference task. Electroencephalogram (EEG) data will be collected during the TMS stimulations and tasks. The main hypothesis is that applying TMS stimulations to the brain targets reduces the response time and response error in the tasks.

Eligibility Criteria

This clinical trial is for healthy volunteers interested in contributing to research on brain stimulation. Participants will undergo MRI scans and TMS sessions while completing tasks, with the aim of improving response times and accuracy.

Inclusion Criteria

I understand the study and can agree to participate.

No metal implants

Absent of lesions or tumors from MRI scans

+2 more

Exclusion Criteria

Prosthetic heart valves

The presence of a cardiac pacemaker or pacemaker wires

I have had brain surgery or have metal clips in my head.

+6 more

Participant Groups

The study tests a new method for targeting brain networks using Transcranial Magnetic Stimulation (TMS) guided by MRI data. It involves two visits: one for MRI scanning and another for four TMS sessions with EEG monitoring during task performance.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Transcranial Magnetic StimulationExperimental Treatment1 Intervention

TMS with the intermittent theta burst stimulation protocol will be applied to the computed brain targets based on the MRI data of each participants.

Group II: Sham Transcranial Magnetic StimulationPlacebo Group1 Intervention

Sham TMS coils will be applied to stimulate the brain targets. No magnetic field will be generated using the sham coil. It will play sounds similar to the true TMS stimulations with the pulsed weak electric current applied to the scalp to generate a similar feeling as in true stimulations.

Transcranial Magnetic Stimulation is already approved in United States, Canada, European Union for the following indications:

🇺🇸 Approved in United States as Transcranial Magnetic Stimulation for: