Nutritionally Balanced Diet for Psoriasis
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of California, Davis
Must not be taking: Anti-diabetics, Systemic psoriasis meds
Disqualifiers: Vegan, Claustrophobia, Uncontrolled diabetes, others
No Placebo Group
Trial Summary
What is the purpose of this trial?Psoriasis is a chronic inflammatory disease that affects the skin and joints in 2-3 % of people in the United States. This inflammation of the skin, joints, and blood vessels in patients with psoriasis has been measured by older PET Scan technology but with limitations. With the new EXPLORER PET scanner technology, the investigators are testing to see if the EXPLORER is better than previous PET scanners and improve our ability to assess inflammation in patients.
Also, it is known that the typical Western Diet - high in saturated fats, added sugars, and low in fiber - contributes to obesity and inflammation worldwide. There is evidence in animals that these signs of inflammation are reversible within 4 weeks when changed to a more balanced diet. Thus, this study aims to assess whether there are detectable decreases in inflammation of the skin and body of psoriasis patients who usually eat a Western Diet on an EXPLORER PET scan following 6 weeks of a more balanced diet.
Will I have to stop taking my current medications?
If you are taking systemic medications for psoriasis or psoriatic arthritis, you must stop them for at least 3 months before the trial and during the trial. Other medications are not specifically mentioned, so it's best to discuss with the trial team.
What data supports the effectiveness of the treatment Nutritionally Balanced Diet for Psoriasis?
Research suggests that a healthy lifestyle, including a balanced diet, can improve psoriasis symptoms. A Mediterranean diet, which is rich in fiber, vitamins, and anti-inflammatory components, may help control psoriasis by positively affecting gut health and reducing inflammation.
12345Is a nutritionally balanced diet safe for humans?
The studies reviewed do not specifically address the safety of a nutritionally balanced diet, but they do not report any safety concerns related to diet in the context of psoriasis or other conditions.
678910How is the Nutritionally Balanced Diet treatment for psoriasis different from other treatments?
The Nutritionally Balanced Diet for psoriasis is unique because it focuses on a healthy eating plan that includes a variety of foods like whole grains, fruits, and vegetables, rather than medication. This approach is similar to the DASH and Mediterranean diets, which are known for improving overall health and managing conditions like high blood pressure and diabetes.
1112131415Eligibility Criteria
This trial is for people with psoriasis, a skin and joint condition. Participants should be those typically consuming a Western Diet high in saturated fats and sugars. The study will use the EXPLORER PET scanner to measure changes in their inflammation after switching to a balanced diet.Inclusion Criteria
I can fast for at least 6 hours before and during my scan appointment.
I am over 18 years old.
No strenuous exercise for 24 hours prior to being scanned
+4 more
Exclusion Criteria
I have been on medication for psoriasis or psoriatic arthritis for at least 3 months.
My blood sugar is not higher than 180 mg/dl and my diabetes is under control.
Vegan, vegetarian, or have food allergy or intolerance to the ingredients of the diet
+12 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Baseline Assessment
Participants undergo baseline PET/CT scans and blood sample collection to measure inflammation markers
1 week
1 visit (in-person)
Dietary Intervention
Participants receive a nutritionally balanced diet for 6 weeks, with meals prepared by a commercial kitchen
6 weeks
Weekly check-ins (virtual)
Post-Intervention Assessment
Participants undergo follow-up PET/CT scans and blood sample collection to measure changes in inflammation markers
1 week
1 visit (in-person)
Follow-up
Participants are monitored for safety and effectiveness after the dietary intervention
4 weeks
Participant Groups
The trial is testing if a nutritionally balanced diet can reduce systemic and cutaneous (skin) inflammation in psoriasis patients. It involves dietary counseling and uses advanced EXPLORER PET scanning technology to quantify inflammation before and after the dietary intervention.
1Treatment groups
Experimental Treatment
Group I: Dietary InterventionExperimental Treatment1 Intervention
Participants will receive breakfast, lunch, and dinner in the form of fully cooked, ready-to-heat standardized meals for 6 weeks that are prepared by a commercial kitchen.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of California, Davis - Dermatology DepartmentSacramento, CA
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Who Is Running the Clinical Trial?
University of California, DavisLead Sponsor
References
Nutritional strategies for psoriasis: current scientific evidence in clinical trials. [2019]Several nutritional strategies for the management of psoriasis are promising. Even if recent data support that nutrition may play a pivotal role in prevention and co-treatment and despite patient's concerns regarding the best nutritional habits, the consensus regarding the nutritional strategies to be adopted lacks in clinical settings. In this manuscript, the effects of several nutritional strategies for psoriasis patients such as hypocaloric diet, vitamin D, fish oil, selenium, and zinc supplementation were systematically reviewed. Randomized controlled trials (RCTs) on beneficial botanical oral supplements were also included in the analysis.
Diet and psoriasis. [2019]Patients with psoriasis have a growing interest in managing their disease through diet.
Metabolic Disorders and Psoriasis: Exploring the Role of Nutritional Interventions. [2023](1) Background: Psoriasis is a chronic autoimmune disease with a close relationship with metabolic diseases such as obesity, diabetes, and dyslipidemia. The aim of this review was to identify the relationship between psoriasis, metabolic diseases, and dietetic therapies. According to recent findings, there is a strong association between psoriasis and obesity as well as vitamin D and micronutrient deficiencies. (2) Methods: This review was conducted via PubMed, aiming to search for studies involving psoriasis linked with metabolic disorders or with nutritional treatments. (3) Results: Our review shows that a healthy lifestyle can positively influence the course of the disease. The maintaining of a proper body weight together with physical activity and good nutritional choices are associated with an improvement in psoriasis severity. A Mediterranean diet rich in fiber, vitamins, and polyphenols may indeed be a strategy for controlling psoriasis symptoms. The effectiveness of this diet lies not only in its anti-inflammatory power, but also in its ability to favorably influence the intestinal microbiota and counteract dysbiosis, which is a risk factor for many autoimmune diseases. (4) Conclusions: In synergy with standard therapy, the adoption of an appropriate diet can be recommended to improve the clinical expression of psoriasis and reduce the incidence of comorbidities.
Nutritional status and food intake of patients with systemic psoriasis and psoriatic arthritis associated. [2019]To identify the nutritional status and food intake of individuals with systemic psoriasis and psoriatic arthritis associated.
Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review. [2019]Psoriasis is a chronic, inflammatory skin disease and has significant associated morbidity and effect on quality of life. It is important to determine whether dietary interventions help reduce disease severity in patients with psoriatic diseases.
Diet and nutrition in psoriasis: analysis of the National Health and Nutrition Examination Survey (NHANES) in the United States. [2014]There is limited research examining the association between psoriasis, dietary intake and nutritional status in the general U.S. population.
Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire. [2018]Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association between diet and psoriasis. The 7-day food records is considered the "gold standard" of self-administered food frequency questionnaires. In this study, we evaluated the differences in the dietary intake, anthropometric measurements and cardio-metabolic risk profile in a group of psoriatic patients compared with an age and Body Mass Index (BMI)-matched control group. In addition, in the group of psoriatic patients we investigated the association between the dietary intake and clinical severity of psoriasis.
Saturated Fatty Acids as Possible Key Amplifiers of Psoriatic Dermatitis. [2019]The association of obesity with psoriasis is well known, but the molecular link between these two entities is incompletely characterized. Herbert et al. report that dietary saturated fatty acids, rather than obesity itself, promote exacerbation of psoriasis in high fat diet-induced obesity. They also suggest that dietary manipulation could improve psoriasis.
Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis. [2022]Psoriasis is characterized by T-helper 17 cell-dominant abnormal immunity, and hyperproliferation and abnormal differentiation of epidermal keratinocytes. Some patients are associated with arthritis. Dietary habits can modulate the pathogenesis of psoriasis. Previous studies in Western countries showed higher body mass indices, higher intake of fat and lower intake of fish or vegetables in psoriatic patients compared with the reference groups. We evaluated dietary habits in adult Japanese psoriatic patients, using a validated brief-type self-administered dietary history questionnaire, and compared the results to those of age- and sex-matched healthy controls. The results in psoriatic patients with arthritis were compared with those in the patients without. Japanese psoriatic patients showed higher body mass indices, higher intake of fish/shellfish, pulses, sugar/sweeteners, vitamin B12 and vitamin D, and lower intake of meat, compared with those of healthy controls. The logistic regression analysis showed that psoriasis was associated with high body mass index and low intake of meat. The intake of confection in patients with high Psoriasis Area and Severity Index was higher than that in those with low index. The intake of β-carotene, vitamin A and green/yellow vegetables in psoriatic patients with arthritis were higher than those in the patients without. The dietary habits in Japanese psoriatic patients are rather different from those in Western patients. This is the first study showing the differences in dietary habits between psoriatic patients with arthritis and those without. Further studies should elucidate the relationships of these results with skin and joint lesions in psoriatic patients.
Dietary inflammatory potential and psoriasis: A cross-sectional study. [2023]Diet is an important source of inflammation, and diet-induced inflammation might be associated with the etiopathogenesis of psoriasis. This study aimed to explore the relationship between dietary inflammatory index (DII), a literature-derived dietary tool to measure individual dietary inflammatory potential, and incident psoriasis. This was a cross-sectional study based on the 2003-2006 and 2009-2014 National Health and Nutrition Examination Surveys. The calculation of DII was based on 24-h dietary recall. Psoriasis was defined by a self-reported medical questionnaire. Logistic regressions were introduced to calculate the odds ratio (OR) and 95% confidence interval (CI) of psoriasis relative to DII. Restricted cubic splines (RCS) were used to test the nonlinear relationship in the regression model. A total of 13 284 participants with an average age of 48.94 ± 17.71 years were enrolled. The prevalence rate psoriasis was 2.88% (95% CI 2.61, 3.18). Incident psoriasis was not associated with DII in a multivariable logistic regression model (OR = 1.00, 95% CI 0.89, 1.11). Compared to participants in the lowest DII tertile, OR for those in the highest was 0.81 (95% CI 0.51, 1.28, P for trend = 0.0974). Subgroup analysis indicated that DII was still not associated with psoriasis in participants with different population settings. RCS showed that DII was not associated with psoriasis in either an overall or a nonlinear manner. Although a proinflammatory diet could lead to several health risks, psoriasis occurrence might not be associated with dietary inflammatory potential in this cross-sectional study.
Effect of high-carbohydrate or high-cis-monounsaturated fat diets on blood pressure: a meta-analysis of intervention trials. [2023]The Dietary Approaches to Stop Hypertension (DASH) diet is recommended to manage blood pressure. The DASH diet is low in saturated fat, but it is not clear whether saturated fat should be preferentially replaced with carbohydrate or unsaturated fat, especially cis-monounsaturated fat.
A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries. [2023]The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study.
The Effect of the Mediterranean Diet on Metabolic Health. [2023]The Mediterranean Diet (MedDiet) is one of the healthiest and most balanced dietary patterns worldwide [...].
DASH Eating Plan: An Eating Pattern for Diabetes Management. [2020]IN BRIEF The DASH (Dietary Approaches to Stop Hypertension) eating plan is an acceptable eating pattern for people who have diabetes. In addition to promoting blood pressure control, this eating pattern has been shown to improve insulin resistance, hyperlipidemia, and even overweight/obesity. This balanced approach promotes consumption of a variety of foods (whole grains, fat-free or low-fat dairy products, fruits, vegetables, poultry, fish, and nuts) and is appropriate for the entire family.
Mediterranean diet and health outcomes: a systematic meta-review. [2019]The Mediterranean diet (MeDi) is considered a healthy dietary pattern, and greater adherence to this diet may improve health status. It also may reduce the social and economic costs of diet-related illnesses. This meta-review aims to summarize, synthesize and organize the effects of MeDi pattern on different health outcomes.