Trial Summary
What is the purpose of this trial?The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and neurological outcome, the impact of physiological-feedback CPR will be assessed. 150 adult patients who have a cardiac arrest event at NYU Tisch Hospital will be randomized to one of two treatment groups: (1) Physiological-Feedback CPR or (2) Non-Physiological (Audiovisual) Feedback CPR.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Goal-Directed CPR for Cardiac Arrest?
Research shows that real-time feedback during CPR can improve the quality of the procedure, which is crucial for patient survival. Studies indicate that using feedback, whether through devices or human input, enhances CPR performance, suggesting that Goal-Directed CPR, which incorporates feedback, could be more effective.
12345How is Goal-Directed CPR for Cardiac Arrest different from other treatments?
Goal-Directed CPR for Cardiac Arrest is unique because it uses real-time feedback and cerebral oximetry (a method to measure oxygen levels in the brain) to guide CPR, aiming to improve the quality of chest compressions and patient outcomes compared to standard CPR methods.
12356Eligibility Criteria
This trial is for adults aged 18-80 who experience a cardiac arrest inside NYU Tisch Hospital and require CPR for at least 5 minutes. It's not open to those with more than two acute organ failures, previous recent cardiac arrests, or certain brain conditions.Inclusion Criteria
I am younger than 80 years old.
You recently had a cardiac arrest while in the hospital.
I am 18 years old or older.
+1 more
Exclusion Criteria
I am between 18 and 80 years old.
People who have had a heart attack outside of the hospital.
I have had 3 or more sudden organ failures.
+5 more
Participant Groups
The study compares two types of CPR in a hospital setting: one using physiological feedback based on cerebral oxygen levels and another using non-physiological audiovisual cues to guide resuscitation efforts.
2Treatment groups
Experimental Treatment
Active Control
Group I: Physiological Feedback CPRExperimental Treatment1 Intervention
Group II: Non-Physiological (Audiovisual) Feedback CPRActive Control1 Intervention
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
NYU Langone HealthNew York, NY
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Who Is Running the Clinical Trial?
NYU Langone HealthLead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)Collaborator
References
Does real-time objective feedback and competition improve performance and quality in manikin CPR training--a prospective observational study from several European EMS. [2018]Previous studies have reported that the quality of cardiopulmonary resuscitation (CPR) is important for patient survival. Real time objective feedback during manikin training has been shown to improve CPR performance. Objective measurement could facilitate competition and help motivate participants to improve their CPR performance. The aims of this study were to investigate whether real time objective feedback on manikins helps improve CPR performance and whether competition between separate European Emergency Medical Services (EMS) and between participants at each EMS helps motivation to train.
Effect of real-time and post-event feedback in out-of-hospital cardiac arrest attended by EMS - A systematic review and meta-analysis. [2022]A systematic review to determine if cardiopulmonary resuscitation (CPR) guided by either real-time or post-event feedback could improve CPR quality or patient outcome compared to unguided CPR in out-of-hospital cardiac arrest (OHCA).
The importance of cardiopulmonary resuscitation quality. [2022]Cardiopulmonary resuscitation (CPR) is a fundamental component of initial care for the victim of cardiac arrest. In the past few years, increasing quantitative evidence has demonstrated that survival from cardiac arrest is dependent on the quality of delivered CPR. This review will focus on this body of evidence and on a range of practical approaches to improving CPR performance.
Short structured feedback training is equivalent to a mechanical feedback device in two-rescuer BLS: a randomised simulation study. [2018]Resuscitation guidelines encourage the use of cardiopulmonary resuscitation (CPR) feedback devices implying better outcomes after sudden cardiac arrest. Whether effective continuous feedback could also be given verbally by a second rescuer ("human feedback") has not been investigated yet. We, therefore, compared the effect of human feedback to a CPR feedback device.
Improving cardiopulmonary resuscitation in the emergency department by real-time video recording and regular feedback learning. [2022]Improvement in the quality of cardiopulmonary resuscitation (CPR) may improve the survival rate following cardiac arrest. The aims of our study were to describe how recording of CPR maneuvers performed in our emergency department with real-time video and regular feedback learning may improve CPR.
Real-time feedback, debriefing, and retraining system of cardiopulmonary resuscitation for out-of-hospital cardiac arrests: a study protocol for a cluster parallel-group randomized controlled trial. [2022]The quality of cardiopulmonary resuscitation (CPR) performed by emergency medical services (EMS) personnel affects patient outcomes after cardiac arrest. A CPR feedback device with an accelerometer mounted on a defibrillator can monitor the motion of the patient's sternum to display and record CPR quality in real time. To evaluate the utility of real-time feedback, debriefing, and retraining using a CPR feedback device outside of the hospital, an open-label, cluster randomized controlled trial will be conducted in five municipalities of Osaka Prefecture, Japan.