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Procedure

Goal-Directed CPR for Cardiac Arrest

N/A
Recruiting
Led By Sam Parnia, MD, PhD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age <80 years
Age ≥18 years
Must not have
Patients < 18 years of age or > 80 years of age
≥3 acute organ failures (defined as acute renal failure requiring dialysis, fulminant liver failure i.e. liver failure with INR≥1.5, respiratory failure requiring mechanical ventilation)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 30
Awards & highlights
No Placebo-Only Group

Summary

This trial will assess whether physiological feedback CPR can improve survival and neurological outcomes in adults who suffer in-hospital cardiac arrests, compared to non-physiological feedback CPR.

Who is the study for?
This trial is for adults aged 18-80 who experience a cardiac arrest inside NYU Tisch Hospital and require CPR for at least 5 minutes. It's not open to those with more than two acute organ failures, previous recent cardiac arrests, or certain brain conditions.
What is being tested?
The study compares two types of CPR in a hospital setting: one using physiological feedback based on cerebral oxygen levels and another using non-physiological audiovisual cues to guide resuscitation efforts.
What are the potential side effects?
Potential side effects are not explicitly listed but may include complications related to the quality of CPR such as varying degrees of neurological outcomes depending on the method used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am younger than 80 years old.
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I am 18 years old or older.
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I have undergone CPR for 5 minutes or longer.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am between 18 and 80 years old.
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I have had 3 or more sudden organ failures.
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I have been treated with a heart-lung machine.
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I have had a recent brain injury, hemorrhage, or a frontal lobe tumor.
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I have been diagnosed with increased pressure in my brain.
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I have had more than one heart attack in the hospital within the last 14 days.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 30
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 30 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Cerebral Performance Category (CPC) Score

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Physiological Feedback CPRExperimental Treatment1 Intervention
Group II: Non-Physiological (Audiovisual) Feedback CPRActive Control1 Intervention

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,411 Previous Clinical Trials
855,522 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,938 Previous Clinical Trials
47,792,305 Total Patients Enrolled
1 Trials studying Ischemia Reperfusion Injury
304 Patients Enrolled for Ischemia Reperfusion Injury
Sam Parnia, MD, PhDPrincipal InvestigatorNYU Langone Health
1 Previous Clinical Trials
520 Total Patients Enrolled

Media Library

Non-Physiological Feedback CPR (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04924985 — N/A
Ischemia Reperfusion Injury Research Study Groups: Physiological Feedback CPR, Non-Physiological (Audiovisual) Feedback CPR
Ischemia Reperfusion Injury Clinical Trial 2023: Non-Physiological Feedback CPR Highlights & Side Effects. Trial Name: NCT04924985 — N/A
Non-Physiological Feedback CPR (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04924985 — N/A
~29 spots leftby Jul 2025
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