Dietary Oxalate Impact on Kidney Stones

Recruiting in Palo Alto (17 mi)

Overseen byTanecia Mitchell, PhD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?

This study will test whether oxalate stimulates urinary crystals and impacts the immune system in healthy subjects using two controlled diets (low and high oxalate).

Research Team

Tanecia Mitchell, PhD

Principal Investigator

University of Alabama at Birmingham

Eligibility Criteria

This trial is for healthy men and women aged 18-60, with a BMI of 20-30, who don't smoke or have kidney stones. Participants must not be pregnant, should avoid vigorous exercise and supplements during the study, and be willing to follow specific diets while collecting urine samples.

Inclusion Criteria

Your body mass index (BMI) is between 20 and 30.

Willing to abstain from vigorous exercise and vitamins/supplements during the study

Your comprehensive metabolic panel (CMP) results are within the normal range.

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Exclusion Criteria

You use tobacco.

My doctor has advised against me joining this trial.

I have ongoing health issues.

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Treatment Details

Interventions

High Oxalate Diet (Dietary Supplement)
Low Oxalate Diet (Dietary Supplement)

Trial OverviewThe study investigates how different levels of dietary oxalate affect urinary crystals formation and immune response in healthy individuals. It involves adhering strictly to either a low or high oxalate diet provided by the researchers.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Low Oxalate Diet Followed by High Oxalate DietExperimental Treatment2 Interventions

Subjects will consume a low oxalate diet for four days, with blood and 24-hour urine collections occurring at baseline and post diet. A ten day wash out period will follow, during which the subject will consume a self-selected diet. Subjects will then consume the high oxalate diet for the final four days, with blood and 24-hour urine collections once again occurring at baseline and post diet.

Group II: High Oxalate Diet Followed by Low Oxalate DietExperimental Treatment2 Interventions

Subjects will consume a high oxalate diet for four days, with blood and 24-hour urine collections occurring at baseline and post diet. A ten day wash out period will follow, during which the subject will consume a self-selected diet. Subjects will then consume the low oxalate diet for the final four days, with blood and 24-hour urine collections once again occurring at baseline and post diet.