Trial Summary
What is the purpose of this trial?The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in patients with moderate to high risk of infection undergoing ureteroscopy. The main questions it aims to answer are:
1. Determine the safety and efficacy of a short course (2 days) as compared to a long course (7 days)
2. Identify secondary predictors of post-operative infectious complications
Eligibility Criteria
This trial is for adults over 18 with kidney stones who are at moderate to high risk of infection and planning to undergo ureteroscopy. They may have a stent, nephrostomy tube, or use catheters like foley or suprapubic. People with asymptomatic bacteriuria, bowel interposition, or immunosuppression can join. Pregnant individuals, those with active infections or recent non-study antibiotics cannot participate.Inclusion Criteria
I am on immunosuppressants, possibly for a transplant or chemotherapy.
asymptomatic bacteriuria
indwelling ureteral stent in place
+4 more
Exclusion Criteria
I took antibiotics not given by this study within a week before surgery.
I do not have any current infections.
pregnancy
Participant Groups
The study compares the effectiveness of taking antibiotics for two days versus seven days before ureteroscopy in preventing post-operative infections. It's a randomized controlled trial aiming to see if a shorter antibiotic course is just as good as a longer one for patients at higher risk of complications.
2Treatment groups
Experimental Treatment
Active Control
Group I: Short duration of preoperative antibiotics (2 days)Experimental Treatment1 Intervention
Group II: Long duration of preoperative antibiotics (7 days)Active Control1 Intervention
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of California, San FranciscoSan Francisco, CA
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Who Is Running the Clinical Trial?
University of California, San FranciscoLead Sponsor