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Radiation Therapy for B-Cell Lymphoma

N/A
Recruiting
Led By Chirayu Patel, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 20 months
Awards & highlights

Study Summary

This trial is studying if a new radiation therapy schedule will be better for people with relapsed/refractory B-cell lymphoma. It could reduce side effects and cost of treatment.

Who is the study for?
This trial is for adults over 18 with B-cell Lymphoma that's come back or hasn't responded to treatment, and who are set to undergo CAR T-cell therapy. They should be able to lay still for the duration of radiation sessions and not have conditions interfering with the study.Check my eligibility
What is being tested?
The study tests a new weekly schedule of Adaptive Bridging Radiation Therapy (ABRT) over five weeks before CAR T-cell therapy in patients with relapsed/refractory B-cell Lymphoma, aiming to improve side effects, time, cost, and effectiveness.See study design
What are the potential side effects?
Potential side effects may include typical reactions from radiation such as skin irritation at the site of treatment, fatigue, nausea, and other symptoms depending on which areas are being targeted by ABRT.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~20 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility: Percent of patients able to undergo ABRT
Secondary outcome measures
Adverse Events
Objective Response Rate (ORR)

Trial Design

1Treatment groups
Experimental Treatment
Group I: 5-5-5 Adaptive Bridging Radiation Therapy (ABRT)Experimental Treatment1 Intervention
5 Gy of adaptive radiation delivered every 5 business days (1 week apart) for up to 5 weeks prior to CAR T-cell therapy infusion

Find a Location

Who is running the clinical trial?

Varian Medical SystemsIndustry Sponsor
60 Previous Clinical Trials
3,774 Total Patients Enrolled
Massachusetts General HospitalLead Sponsor
2,945 Previous Clinical Trials
13,203,868 Total Patients Enrolled
Chirayu Patel, MDPrincipal InvestigatorMassachusetts General Hospital
~0 spots leftby Jul 2024
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