Transcranial Magnetic Stimulation + Episodic Future Thinking for Methamphetamine Addiction

Recruiting in Palo Alto (17 mi)

Overseen byHeather Webber, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: The University of Texas Health Science Center, Houston

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this study is to assess impact of repetitive transcranial magnetic stimulation (rTMS)+Episodic Future Thinking (EFT) vs. sham rTMS+EFT on delay discounting and methamphetamine (MA) demand, on vividness of future positive events during EFT training and on frequency of episodic thinking during the week following EFT training

Eligibility Criteria

This trial is for English-speaking individuals with a primary diagnosis of methamphetamine use disorder, as per DSM-5. Participants must not have severe substance use disorders other than methamphetamine and marijuana, no major medical or psychiatric conditions that could affect the study, and cannot be pregnant or nursing.

Inclusion Criteria

Meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for primary methamphetamine use disorder

Be fluent in English and able to understand the consent form

Exclusion Criteria

I have a history of epilepsy or seizures.

Current DSM-5 diagnosis for any illicit substance use disorder other than methamphetamine and marijuana

Current DSM-5 diagnosis of moderate or greater severity for alcohol and marijuana use disorder

+13 more

Participant Groups

The study is testing whether combining repetitive transcranial magnetic stimulation (rTMS) with Episodic Future Thinking (EFT) can influence decision-making, cravings for methamphetamine, and the ability to imagine future events compared to a sham rTMS plus EFT.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: highfrequency rTMS+EFTExperimental Treatment2 Interventions

Group II: sham rTMS+EFTPlacebo Group2 Interventions