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E-Cigarette Flavors for Electronic Cigarette Use

N/A
Recruiting
Led By Danielle Davis
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
21-44 years old
Be between 18 and 65 years old
Must not have
Non-stable Rx medication
Not fully vaccinated for Coronavirus (e.g. COVID-19)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediately after intervention, up to 15 minutes
Awards & highlights

Summary

This trial aims to study how gender affects people's perception of the taste, appeal, and addictive properties of e-cigarettes with nicotine in sweet and cooling flavors.

Who is the study for?
This trial is for individuals aged 21-44 who currently smoke cigarettes and have used e-cigarettes at least 10 times in the past six months. Participants must be able to read/write, not planning to quit smoking soon, and willing to avoid nicotine/tobacco for 6-8 hours before lab sessions.
What is being tested?
The study aims to understand how gender affects the sensory effects, appeal, and desire for nicotine-containing e-cigarettes with popular flavors that are sweet or cooling. Three different e-liquid flavors are being tested.
What are the potential side effects?
While specific side effects aren't listed, using flavored e-liquids can potentially include throat irritation, coughing, or an allergic reaction depending on individual sensitivity to ingredients.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 21 and 44 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My medication doses are frequently changing.
Select...
I am not fully vaccinated against COVID-19.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediately after intervention, up to 15 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately after intervention, up to 15 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Appeal
Reinforcing Efficacy
Sensory Effects

Trial Design

3Treatment groups
Experimental Treatment
Group I: Experimental E-Liquid Order "C"Experimental Treatment3 Interventions
All participants will be given all e-liquids (i.e. 3 flavor conditions all containing nicotine) in this within subject cross-over design study. Participants will be randomized in the order in which they receive the flavor conditions (across 3 visits).
Group II: Experimental E-Liquid Order "B"Experimental Treatment3 Interventions
All participants will be given all e-liquids (i.e. 3 flavor conditions all containing nicotine) in this within subject cross-over design study. Participants will be randomized in the order in which they receive the flavor conditions (across 3 visits).
Group III: Experimental E-Liquid Order "A"Experimental Treatment3 Interventions
All participants will be given all e-liquids (i.e. 3 flavor conditions all containing nicotine) in this within subject cross-over design study. Participants will be randomized in the order in which they receive the flavor conditions (across 3 visits).

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,907 Previous Clinical Trials
3,018,989 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,543 Previous Clinical Trials
3,249,316 Total Patients Enrolled
Danielle DavisPrincipal InvestigatorYale University
~39 spots leftby Jul 2025
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