Carbon Dioxide Breathing for Orthostatic Hypotension

N/A

Recruiting

Led By Satish R Raj, MD

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≥18 years

Be older than 18 years old

Must not have

Subjects who require portable oxygen at rest or with exercise

Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath

Timeline

Screening 3 weeks

Treatment Varies

Follow Up the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing if breathing in carbon dioxide can help people with Neurogenic Orthostatic Hypotension, a condition where the "fight-or-flight" part of the nervous system fails.

Who is the study for?

This trial is for adults over 18 who can consent, travel to the University of Calgary, and are non-smokers. It's not for those with dementia, substance abuse issues, severe organ diseases, pregnant or breastfeeding women, people on certain medications affecting autonomic function or unable to wear a mask.

What is being tested?

The study tests if breathing in higher levels of carbon dioxide (Sequential Gas Delivery) can help manage low blood pressure when standing in patients with Neurogenic Orthostatic Hypotension by increasing blood pressure and brain blood flow.

What are the potential side effects?

Potential side effects may include discomfort from wearing a mask to deliver the gas and possible short-term changes in respiratory patterns due to increased carbon dioxide inhalation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I need portable oxygen for breathing, either at rest or during physical activity.

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I cannot climb stairs without feeling short of breath due to heart or lung problems.

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I do not have conditions like dementia, substance abuse, stroke, kidney or liver disease, or surgeries affecting my nervous system.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2

This trial's timeline: 3 weeks for screening, Varies for treatment, and the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2 for reporting.