Diagnostic Imaging Techniques for Shoulder Osteoarthritis
(UESOA Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byPeter Lapner, MD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Ottawa Hospital Research Institute

No Placebo Group

Trial Summary

What is the purpose of this trial?Osteoarthritis (OA) is a progressive disease resulting from the degradation of synovial joint articular cartilage over time. The hallmark symptom is diffuse aching and progressive pain made worse with activity. Loss of range of motion and compromised function inevitably follow. This degenerative disease can affect the shoulder joint. When symptoms become refractory to conservative treatment such as anti-inflammatory medication, steroid injections, activity modification or physical therapy; surgery (total or reverse shoulder arthroplasty) may be considered. Idiopathic shoulder OA is typically characterized by posterior subluxation of the humeral head upon the glenoid and posterior bone loss. An imbalance in the application of forces applied to the proximal humerus by the posterior and anterior rotator cuff muscles has been postulated to be the leading cause of idiopathic shoulder OA. However, there is only preliminary evidence to support this theory and the etiology of this pattern of deformity is unknown. The theory the posterior humeral head subluxation is a precursor to OA is only supported by very low-level evidence and no longitudinal studies have been conducted. As a result, the cause and natural history of shoulder OA remains unknown. Research into this area is urgently needed to generate knowledge that will inform future treatments aimed at modifying and slowing the progression of shoulder OA and to reduce the need for shoulder replacement therapy. The aim of this project is to develop an understanding of the pathophysiology of shoulder OA.

Eligibility Criteria

This trial is for adults under 60 with shoulder osteoarthritis, specifically those showing more than 55% posterior humeral head subluxation on imaging. It's not suitable for individuals over 60, those with labral or rotator cuff issues, pre-existing joint deformities beyond grade I, neurological disorders of the upper limb, history of shoulder instability or trauma including fractures.

Inclusion Criteria

Posterior humeral head subluxation >55% (determined from imaging)

I am younger than 60 years old.

Exclusion Criteria

I am over 60 years old.

I have a joint deformity more severe than mild.

I have a rotator cuff injury.

+5 more

Participant Groups

The study aims to understand the causes and progression of shoulder osteoarthritis by using low-dose CT scans, T1Rho MRI imaging techniques and motion analysis to observe changes in the joint over time.

2Treatment groups

Experimental Treatment

Active Control

Group I: Group 1: Early Degeneration ('Disease')Experimental Treatment3 Interventions

Those who have posterior subluxation of the humeral head and show early signs of degeneration in their shoulder.

Group II: Group 2: No Degeneration ('Healthy')Active Control3 Interventions

Those who have posterior subluxation of the humeral head and show no signs of degeneration.