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Resistance vs Endurance Exercise for Osteoporosis (MOVE Trial)

N/A

Recruiting

Led By Sarah J Wherry, PhD

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Fracture in the past 6 months

History of type 1 or type 2 diabetes

Timeline

Screening 3 weeks

Treatment Varies

Follow Up serum ica is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours),

Awards & highlights

No Placebo-Only Group

Summary

This trial will compare how two types of exercise affect bone resorption in adults. It is not known if resistance exercise causes a similar increase in bone resorption as endurance exercise, or if exercise training affects the increase in bone resorption following exercise for both endurance and resistance exercise.

Who is the study for?

This trial is for healthy older veterans aged 60+ in the Denver area who are normally active, like walking or cycling. They can't join if they have liver disease, kidney problems, anemia, diabetes, thyroid issues, abnormal calcium levels, severe high blood pressure, recent COVID-19 symptoms or diagnosis, a fracture within the last six months or heart disease.

What is being tested?

The study tests how two types of exercise affect bone health markers in older adults. Participants will do either 10 weeks of supervised resistance training (like lifting weights) or endurance training (like running), to see which one is better for bones.

What are the potential side effects?

While not explicitly stated for this trial since it's about exercise interventions rather than medications; potential side effects may include muscle soreness and fatigue from resistance exercises and joint impact concerns from endurance activities.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had a bone break in the last 6 months.

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I have a history of diabetes (type 1 or 2).

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My kidney function is reduced, with an eGFR below 60.

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I am currently diagnosed with or showing symptoms of COVID-19.

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My liver tests are higher than normal.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ serum tca is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours).

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~serum tca is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours).

This trial's timeline: 3 weeks for screening, Varies for treatment, and serum tca is measured before exercise (-15, 0 minutes) and after exercise (60, 120, 300 minutes and 24 and 48 hours). for reporting.