Resistance vs Endurance Exercise for Osteoporosis
(MOVE Trial)
Trial Summary
What is the purpose of this trial?
Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment 10 Weeks of Supervised Endurance Exercise Training, Supervised Aerobic Exercise, Endurance Training Program, 10 Weeks of Supervised Resistance Exercise Training, Resistance Training, Strength Training for osteoporosis?
Research shows that exercise, including endurance and resistance training, can help maintain bone health and prevent fractures in people with osteoporosis. Specifically, endurance-strength training has been found to increase bone mineral density in certain areas, and both endurance and resistance exercises improve physical capacity and reduce fall risk.12345
Is resistance and endurance exercise generally safe for humans?
Research suggests that both resistance and endurance exercises can be safe for humans when properly supervised and tailored to individual health conditions. For example, resistance training at low intensities and with high repetitions is considered safe for certain cardiac patients, and both endurance and endurance-strength training have been shown to improve physical capacity without significant safety concerns in postmenopausal women.16789
How does the 10-week supervised exercise treatment for osteoporosis differ from other treatments?
This treatment is unique because it involves a structured exercise program focusing on either endurance or resistance training, which can improve muscle strength and coordination, potentially benefiting bone health. Unlike medications, this approach emphasizes physical activity to help manage osteoporosis, although its exact impact on bone density compared to other treatments remains uncertain.110111213
Research Team
Sarah J Wherry, PhD
Principal Investigator
Rocky Mountain Regional VA Medical Center, Aurora, CO
Eligibility Criteria
This trial is for healthy older veterans aged 60+ in the Denver area who are normally active, like walking or cycling. They can't join if they have liver disease, kidney problems, anemia, diabetes, thyroid issues, abnormal calcium levels, severe high blood pressure, recent COVID-19 symptoms or diagnosis, a fracture within the last six months or heart disease.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo 10 weeks of supervised exercise training, either resistance training or endurance exercise, 3 times per week
Follow-up
Participants are monitored for changes in bone biomarkers and physical performance after exercise sessions
Treatment Details
Interventions
- 10 Weeks of Supervised Endurance Exercise Training (Behavioural Intervention)
- 10 Weeks of Supervised Resistance Exercise Training (Behavioural Intervention)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
University of Colorado, Denver
Collaborator