Plant vs Whey Protein for Protein Metabolism
Trial Summary
What is the purpose of this trial?
The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, you cannot participate if you are using long-term oral corticosteroids or have used a short course of oral corticosteroids within 4 weeks before the study.
What data supports the effectiveness of the treatment in the clinical trial titled 'Plant vs Whey Protein for Protein Metabolism'?
Research shows that soy protein can improve muscle function and has a high nutritional value, with 91% digestibility and 78% net protein utilization. Additionally, a blend of dairy and vegetable proteins, including soy and pea, offers a balanced amino acid profile, which is important for muscle growth and maintenance.12345
Is soy protein isolate safe for human consumption?
Research indicates that soy protein isolate is generally safe for human consumption, as studies have shown no significant adverse effects on blood lipids or platelet aggregation in normal men. However, some individuals with milk protein enterocolitis may also react to soy protein, suggesting a potential for allergic reactions in sensitive individuals.16789
How does the treatment using plant and whey protein isolates differ from other treatments for protein metabolism?
This treatment is unique because it compares plant-based proteins like pea and soy with animal-based whey protein, focusing on their effects on protein metabolism. The study highlights the sustainability of plant proteins and their potential to support protein synthesis, although whey protein shows a higher immediate increase in essential amino acids.68101112
Eligibility Criteria
This trial is for older adults with sarcopenia, which is a condition involving loss of muscle mass and strength. Participants should be interested in how different protein sources affect their metabolism.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive dietary supplements of either whey protein, soy protein, pea protein, or placebo over 4 study days
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Organic Pea Protein Isolate (Protein Supplement)
- Soy Protein Isolate (90% Protein) (Protein Supplement)
- Whey Protein Isolate 90% (Protein Supplement)