Natural History Study for Retinitis Pigmentosa (PHENOROD2 Trial)

Palo Alto (17 mi)

Overseen bySaddek Mohand-Saïd, M.D, Ph.D

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: SparingVision

No Placebo Group

Trial Summary

What is the purpose of this trial?This is natural history study of rods and cones degenerations in patients with Retinitis Pigmentosa (RP) caused by pathogenic mutations in RHO, PDE6a or PDE6b gene mutations.

Eligibility Criteria

This study is for individuals with Retinitis Pigmentosa, a degenerative eye condition, specifically caused by mutations in the RHO, PDE6A or PDE6B genes. Participants must have a certain level of visual acuity and field diameter, understand the local language well enough to follow instructions, and be part of a health system if they're in France. Pregnant women or those with other retinal issues are excluded.

Inclusion Criteria

My retinitis pigmentosa is due to mutations in RHO, PDE6A, or PDE6B genes.

Exclusion Criteria

I have a gene mutation linked to retinitis pigmentosa.

I have an eye condition that could affect my retina's function.

Treatment Details

The trial involves regular eye exams and mobility tests to track how Retinitis Pigmentosa progresses over time when it's caused by specific genetic mutations. It's an observational study meaning there's no treatment being tested; instead, researchers are studying the natural course of the disease.

2Treatment groups

Experimental Treatment

Group I: Study Group 2Experimental Treatment2 Interventions

Four years follow-up of patients with ophthalmic examination and mobility testing.

Group II: Study Group 1Experimental Treatment1 Intervention

Four years follow up of patients with ophthalmic examination.