Diesel Exhaust and Wood Smoke for Air Pollution Exposure
(WADE Trial)

Recruiting in Palo Alto (17 mi)

Overseen byChris Carlsten, MD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of British Columbia

Trial Summary

What is the purpose of this trial?

Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.

Research Team

Chris Carlsten, MD

Principal Investigator

University of British Columbia

Eligibility Criteria

This trial is for individuals with or without rhinitis (including hay fever) who are generally healthy. It aims to understand how different types of air pollution affect health.

Inclusion Criteria

I am between 19 and 40 years old.

I am healthy and have never had a lung disease.

Lifetime non-smoker and non-vaper

Exclusion Criteria

I am often exposed to smoke or diesel exhaust at home or work.

Pregnant, planning to become pregnant, or breastfeeding during the study period (confirmed through pregnancy tests at each visit if applicable)

Treatment Details

Interventions

Diesel Exhaust and Wood Smoke (DEWS) (Other)
Diesel Exhaust (DE) (Other)
Filtered Air (FA) (Other)
Wood Smoke (WS) (Other)

Trial OverviewThe study compares the health effects of breathing in diesel exhaust and wood smoke versus filtered air. Participants will be exposed to these conditions in a controlled environment to assess acute health changes.

Participant Groups

4Treatment groups

Active Control

Placebo Group

Group I: Wood Smoke (WS)Active Control1 Intervention

Participants will be exposed to 2 hours of controlled wood smoke (WS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Group II: Diesel Exhaust (DE)Active Control1 Intervention

Participants will be exposed to 2 hours of controlled diesel exhaust (DE) as a model of traffic-related air pollution (TRAP) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Group III: Diesel Exhaust and Wood Smoke (DEWS)Active Control1 Intervention

Participants will be exposed to 2 hours of combined controlled diesel exhaust (DE) and wood smoke (DEWS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).

Group IV: Filtered Air (FA)Placebo Group1 Intervention

Participants will be exposed to 2 hours of high-efficiency particulate air (HEPA) filtered air (FA).