Sleep Deprivation for Heart Function During Exercise
Recruiting in Palo Alto (17 mi)
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Guelph
Must be taking: Oral contraceptives
Must not be taking: Chronic medications
Disqualifiers: Cardiovascular, Metabolic, Sleep disorders, others
No Placebo Group
Trial Summary
What is the purpose of this trial?
The goal of this clinical trial is to determine if attenuations in cardiac output drive the blunted blood pressure response during cycling exercise following a night of partial sleep deprivation in young healthy adults (%50 females). The secondary outcome is to assess sex differences. The main questions it aims to answer are: * Do reductions in plasma volume drive reductions in cardiac output and therefore blood pressure during exercise following a night of partial sleep deprivation? * Do sex differences exist? Participants will: * Visit the lab after a night of normal sleep and a night of partial sleep deprivation. * Keep a daily diary of their sleep and food/beverage intake. * Perform maximal and submaximal exercise on a cycle ergometer.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it does exclude people who are on chronic medications other than oral contraceptives. This suggests that you might need to stop other chronic medications to participate.
What data supports the effectiveness of the treatment Partial Sleep Deprivation for heart function during exercise?
Is sleep deprivation generally safe for humans during exercise?
How does the treatment of partial sleep deprivation differ from other treatments for heart function during exercise?
Partial sleep deprivation is unique because it involves intentionally reducing sleep to study its effects on heart function during exercise, unlike other treatments that might focus on medication or lifestyle changes. This approach examines how lack of sleep affects the body's autonomic (automatic body functions) and endocrine (hormone-related) systems, which can influence heart rate and exercise performance.268910
Eligibility Criteria
This trial is for young, healthy adults interested in how lack of sleep affects heart function during exercise. Participants will need to visit the lab after both a normal night's sleep and a night with less sleep, keep track of their sleep and eating habits, and do cycling exercises.Inclusion Criteria
Able to abide by sleep protocols for all visits
No history of smoking (within the past 3 months)
Able to engage in physical activity assessed through the physical activity readiness questionnaire (PAR-Q+)
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Exclusion Criteria
Has a history of smoking (within the past 3 months)
I am on long-term medication other than birth control pills.
Unable to abide by sleep protocols for any testing visit
See 4 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
1-2 weeks
Baseline Assessment
Participants undergo assessment of maximal oxygen uptake to determine aerobic fitness and metabolic exercise intensity zones
1 visit
1 visit (in-person)
Intervention
Participants visit the lab after a night of normal sleep and a night of partial sleep deprivation to perform cycling exercise and have hemodynamics and plasma volume measured
2 visits
2 visits (in-person)
Follow-up
Participants are monitored for safety and effectiveness after the intervention
1-2 weeks
Treatment Details
Interventions
- Partial Sleep Deprivation (Behavioural Intervention)
Trial OverviewThe study aims to see if not getting enough sleep leads to lower blood pressure because of reduced heart output when exercising. It also looks at whether men and women react differently to this kind of stress.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Partial sleep deprivationExperimental Treatment1 Intervention
During this arm, participants will be asked to come to the lab for testing after a night of partial sleep deprivation. Participants will be asked to fall asleep at their habitual bedtime but wake up early (\~40% of normal sleep duration).
Group II: Normal sleepActive Control1 Intervention
During this arm, participants will be asked to come to the lab for testing after a night of normal sleep. Normal sleep will be defined as participants habitual sleep-wake timing.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of GuelphGuelph, Canada
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Who Is Running the Clinical Trial?
University of GuelphLead Sponsor
References
Acute partial sleep deprivation and high-intensity interval exercise effects on postprandial endothelial function. [2021]Acute-total and chronic-partial sleep deprivation increase the risks for cardiovascular disease (CVD). Cardiovascular function assessed by flow mediated dilation (FMD) is reduced after sleep deprivation. High-intensity interval exercise (HIIE) improves postprandial FMD. Sleep-deprived individuals may practice HIIE followed by a high-fat breakfast. This study investigated the acute-partial sleep deprivation (APSD) and HIIE interaction on postprandial FMD.
Effects of sleep disturbances on subsequent physical performance. [2019]The purpose of the study was to compare the cardiovascular, respiratory and metabolic responses to exercise of highly endurance trained subjects after 3 different nights i.e. a baseline night, a partial sleep deprivation of 3 h in the middle of the night and a 0.25-mg triazolam-induced sleep. Sleep-waking chronobiology and endurance performance capacity were taken into account in the choice of the subjects. Seven subjects exercised on a cycle ergometer for a 10-min warm-up, then for 20 min at a steady exercise intensity (equal to the intensity corresponding to 75% of the predetermined maximal oxygen consumption) followed by an increased intensity until exhaustion. The night with 3 h sleep loss was accompanied by a greater number of periods of wakefulness (P less than 0.01) and fewer periods of stage 2 sleep (P less than 0.05) compared with the results recorded during the baseline night. Triazolam-induced sleep led to an increase in stage 2 sleep (P less than 0.05), a decrease in wakefulness (P less than 0.05) and in stage 3 sleep (P less than 0.05). After partial sleep deprivation, there were statistically significant increases in heart rate (P less than 0.05) and ventilation (P less than 0.05) at submaximal exercise compared with results obtained after the baseline night. Both variables were also significantly enhanced at maximal exercise, while the peak oxygen consumption (VO2) dropped (P less than 0.05) even though the maximal sustained exercise intensity was not different.(ABSTRACT TRUNCATED AT 250 WORDS)
Exercise after sleep deprivation. [2019]The influence of acute sleep loss on subsequent exercise remains poorly defined. To investigate this question, six subjects performed cycle ergometer exercise daily in a 3-d series that included 30 h without sleep before day 2, and then unlimited sleep before day 3. Each day 8 min of exercise was performed at each of three constant external work loads that required approximately 25%, 50%, and 75% of the VO2max. On days 2 and 3 after sleep loss, exercise at all work loads resulted in unchanged O2 uptake (VO2), CO2 production (VO2), CO2 production (VCO2), ventilation (VE), heart rate, and arterial blood perssure, when compared with the equivalent day in a control series. Despite these unchanged physiological variables, ratings of preceived exertion were increased significantly during moderate and heavy exercise on day 2 (P less than 0.05), but returned to control levels on day 3. In further experiments on six additional subjects, sleep loss failed to alter VO2max, while it significantly reduced peak exercise heart rate (P less than 0.05). These results suggest that acute sleep deprivation primarily alters the psychological responses to moderate and heavy exercise.
[Disturbance of sports performance after partial sleep deprivation]. [2006]The changes in cardiac and ventilatory responses were measured in 7 endurance athletes during physical exercise on a bicycle ergometer, taking place after a control night and after a night with partial sleep deprivation in the middle of the night. The results show that, despite the maximal work load was not modified with control, heart rate, ventilation and VE/VO2 ratio (ERO2) were greater at the submaximal (75% of the VO2 max) and maximal work load and oxygen consumption decreased at maximal work, after the night of partial sleep deprivation as compared to the control. These findings suggest that acute sleep loss may contribute to alter the endurance performance by impairment of aerobic pathways.
Hormonal responses to exercise after partial sleep deprivation and after a hypnotic drug-induced sleep. [2018]The aim of this study was to determine the hormonal responses, which are dependent on the sleep wake cycle, to strenuous physical exercise. Exercise was performed after different nocturnal regimens: (i) a baseline night preceded by a habituation night; (ii) two nights of partial sleep deprivation caused by a delayed bedtime or by an early awakening; and (iii) two nights of sleep after administration of either a hypnotic compound (10 mg zolpidem) or a placebo. Eight well-trained male endurance athletes with a maximal oxygen uptake of 63.5 +/- 3.8 ml x kg(-1) x min(-1) (mean value +/- s(x)) were selected on the basis of their sleeping habits and their physical training. Polygraphic recordings of EEG showed that both nights with partial sleep loss led to a decrease (P
One night of partial sleep deprivation increased biomarkers of muscle and cardiac injuries during acute intermittent exercise. [2022]The aim of this study was to evaluate the effect of two types of partial sleep deprivation (PSD) on biomarkers of muscle and cardiac injuries in response to acute intermittent exercise in professional athletes.
Sleep deprivation and cardiorespiratory function. Influence of intermittent submaximal exercise. [2019]The effects of 64 h of sleep deprivation upon cardiorespiratory function was studied in 11 young men (VO2max = 55.5 ml kg-1 min-1, STPD). Six subjects engaged in normal sedentary activities, while the others walked on a treadmill at 28% VO2max for one hour in every three; eight weeks later, sleep deprivation was repeated with a crossover of subjects. Immediate post-deprivation measurement of VO2max showed a small but statistically significant decrease (-3.8 ml min-1 kg-1, STPD), with no difference between exercise and control trials. The final decrement in aerobic power was not due to a loss of motivation, as 88% (21 of 24) of post-deprivation tests still showed a plateau of VO2max; in addition, terminal heart rates (198 vs 195 beats min-1), respiratory exchange ratios (1.14 vs 1.15) and blood lactate levels (12.1 vs 11.8 mmol l-1) were not significantly different after sleep deprivation. The decrease in VO2max was associated with a lower VEmax (127 vs 142 l min-1, BTPS) and a substantial haemodilution (13%). Physiological responses to sub-maximal exercise showed persistence of the normal diurnal rhythm in heart rate and oxygen consumption, with no added effects due to sleep deprivation. However, ratings of perceived exertion (Borg scale) increased significantly throughout sleep deprivation. The findings are consistent with a mild respiratory acidosis, secondary to reduced cortical arousal and/or a progressive depletion of tissue glycogen stores which are not altered appreciably by moderate physical activity.
Sleep deprivation and the effect on exercise performance. [2018]Sleep deprivation or partial sleep loss are common in work conditions as rotating shifts and prolonged work hours, in sustained military operations and in athletes competing in events after crossing several time zones or engaged in ultramarathon or triathlon events. Although it is well established that sleep loss has negative effects on mental performance, its effects on physical performance are equivocal. This review examines the latter question in light of recent studies published on this problem. Sleep deprivation of 30 to 72 hours does not affect cardiovascular and respiratory responses to exercise of varying intensity, or the aerobic and anaerobic performance capability of individuals. Muscle strength and electromechanical responses are also not affected. Time to exhaustion, however, is decreased by sleep deprivation. Although ratings of perceived exertion always increased during exercise in sleep-deprived (30 to 60 hours) subjects compared with normal sleep, this is not a reliable assessment of a subject's ability to perform physical work as the ratings of perceived exertion are dissociated from any cardiovascular changes in sleep deprivation. Examination of the various hormonal and metabolic parameters which have been measured in the studies reviewed reveals that the major metabolic perturbations accompanying sleep deprivation in humans are an increase in insulin resistance and a decrease in glucose tolerance. This may explain the reduction in observed time to exhaustion in sleep-deprived subjects. The role of growth hormone in mediating altered carbohydrate metabolism may be of particular relevance as to how sleep deprivation alters the supply of energy substrate to the muscle.
Effects of sleep deprivation on autonomic and endocrine functions throughout the day and on exercise tolerance in the evening. [2013]The aim of this study was to investigate the effects of sleep deprivation on autonomic and endocrine functions during the day and on exercise tolerance in the evening. Ten healthy young males completed two, 2-day control and sleep deprivation trials. For the control trial, participants were allowed normal sleep from 23:00 to 07:00 h. For the sleep deprivation trial, participants did not sleep for 34 h. Autonomic activity was measured from 19:00 h on day 1 to 16:00 h on day 2 by frequency-domain measures of heart rate variability. Endocrine function was examined by measuring adrenocorticotropic hormone and cortisol from venous blood samples collected on day 2 at 09:00, 13:00, and 17:00 h and immediately after an exercise tolerance testing. Autonomic regulation, particularly parasympathetic regulation estimated from the high-frequency component of heart rate variability analysis, was significantly higher in the sleep deprivation trial than in the control trial in the morning and afternoon of day 2. Plasma adrenocorticotropic hormone concentrations were significantly higher at 09:00 and 13:00 h of day 2 under sleep deprivation. Heart rate during exercise was significantly lower following sleep deprivation. Therefore, the effects of sleep deprivation on autonomic regulation depend on the time of the day.
Effects of High-Intensity Interval Exercise and Acute Partial Sleep Deprivation on Cardiac Autonomic Modulation. [2021]Sleep deprivation in healthy adults has been associated with disrupted autonomic nervous system function, which in turn has been linked to cardiovascular health. High-intensity interval exercise (HIIE) may affect both sleep and cardiac autonomic modulation. Purpose: To investigate the impact of acute partial sleep deprivation on autonomic cardiac regulation before and after an acute bout of HIIE and the length of time for the autonomic system to return to resting levels. Methods: Fifteen healthy males with body mass index (BMI) of 25.8 ± 2.7 kg·m-2 and age 31 ± 5 y participated in a reference sleep (~9.5 hr) with no HIIE (RS), a reference sleep with HIIE (RSX), and an acute partial sleep deprivation (~3.5 hr) with HIIE (SDX). HIIE was performed in 3:2 intervals at 90% and 40% of VO2 reserve. Autonomic regulation through HRV selected time and frequency domain indices were recorded the night before, the morning of the next day, 1 hr-, 2 hr-, 4hr-, and 6-hr post-exercise. Results: HIIE performed in a 3:2 W:R ratio decreased the HRV (p < .05) at 1-hr post exercise and it took up to 4 hr to return to baseline levels. Parasympathetic related HRV indices increased the morning of the next day for SDX (p < .05). Acute partial sleep deprivation and HIIE did not modify the HRV responses compared to reference sleep and HIIE. Conclusion: HRV disturbance typically seen in responses to an acute episode of HIIE is not influenced by acute partial sleep deprivation.