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TMS for Spatial Navigation

N/A

Recruiting

Led By Travis E Baker

Research Sponsored by Rutgers, The State University of New Jersey

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 0 (day of testing)

Summary

This trial will examine how transcranial magnetic stimulation (TMS) affects brain activity & spatial processing during goal-directed navigation tasks. Results may show how TMS affects task performance & spatial encoding of rewards.

Who is the study for?

This trial is for adults aged 18-55 with stable mental and physical health, who haven't had substance abuse treatment in the last month. Participants must not be pregnant, have a history of significant brain disorders or metal implants that affect MRI scans, and should be able to follow study procedures.

What is being tested?

The trial tests how Transcranial Magnetic Stimulation (TMS) affects spatial processing during virtual navigation tasks. It compares active TMS pulses against sham (placebo) pulses on the parietal cortex to see if they influence spatial memory and decision-making.

What are the potential side effects?

Possible side effects of TMS may include discomfort at the stimulation site, headache, lightheadedness, or seizures; however, these are generally rare. The sham procedure is designed to mimic TMS without active stimulation and typically has fewer side effects.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 0 (day of testing)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 0 (day of testing)

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 0 (day of testing) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Event-related Brain Oscillation: Right Posterior Theta

Spatial Recall performance

Trial Design

4Treatment groups

Experimental Treatment

Placebo Group

Group I: Active single-pulse rTMSExperimental Treatment1 Intervention

For the first TMS session, participants will receive a single TMS pulse during the phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 300 pulses. For the second TMS session, participants will receive single pulse TMS during the phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 200 pulses.

Group II: Active 10-Hz rTMSExperimental Treatment1 Intervention

For the first TMS session, participants will receive 10-Hz repetitive TMS (rTMS) delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 2250 pulses. For the second TMS session, participants will receive single pulse TMS during the phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 200 pulses.

Group III: Sham 10-Hz rTMSPlacebo Group1 Intervention

Identical parameters of the active 10-Hz rTMS group will be applied to the SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation.

Group IV: Sham single-pulse rTMSPlacebo Group1 Intervention

Identical parameters of the active single-pulse rTMS group will be applied to the SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation.

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