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Motor Rehabilitation for Stroke

Columbus, OH

N/A

Waitlist Available

Led By Yousef Hannawi, MD

Research Sponsored by Ohio State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Kidney disease as evidenced by eGFR<60

Anemia

Timeline

Screening 3 weeks

Treatment Varies

Follow Up participants will be followed for 4-6 weeks. change in motor function at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured.

Awards & highlights

No Placebo-Only Group

Summary

This trial will help researchers understand how constraint-induced movement therapy (CI therapy) helps the brain "rewire" itself after stroke, in hopes of improving rehabilitation methods.

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Who is the study for?

This trial is for adults over 18 who had a stroke at least 6 months ago, resulting in mild to moderate hemiparesis but can still understand and participate in therapy. It's not for those with severe medical conditions, recent botulinum toxin injections, intensive post-stroke rehab, kidney issues, metallic/electronic implants incompatible with MRI, or claustrophobia.Check my eligibility

What is being tested?

The study tests Constraint-induced movement therapy (CI therapy) which helps the brain 'rewire' after chronic stroke. Using advanced MRI techniques to observe changes in grey matter and blood flow will infer cellular processes behind brain reorganization during CI therapy.See study design

What are the potential side effects?

Since this trial involves non-invasive MRI scans and physical rehabilitation exercises rather than drugs or invasive procedures, side effects are minimal but may include discomfort from remaining still during scans or fatigue from the exercises.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My kidney function is reduced with an eGFR below 60.

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I have anemia.

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I do not have severe health issues like dementia or uncontrollable pain.

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I have received a botulinum toxin injection in the last 3 months.

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I have sickle cell disease.

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I have had a kidney transplant.

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I have a history of kidney disease.

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Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ participants will be followed for 4-6 weeks. change in brain structure at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~participants will be followed for 4-6 weeks. change in brain structure at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured.

This trial's timeline: 3 weeks for screening, Varies for treatment, and participants will be followed for 4-6 weeks. change in brain structure at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured. for reporting.