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Adrenergic Antibody

Healthy (control) Subjects for Postural Orthostatic Tachycardia Syndrome

N/A
Recruiting
Led By Satish R Raj, MD, MSCI
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year (to measure adrenergic antibody assay)
Awards & highlights

Summary

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.

Eligible Conditions
  • Postural Orthostatic Tachycardia Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year (to measure adrenergic antibody assay)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year (to measure adrenergic antibody assay) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The proportion of alpha-1 Ab titer positive subjects
Secondary outcome measures
Antibody Positivity by Clinical Autoimmune Syndromes
Antibody Positivity by Joint Hypermobility Status
Antibody Positivity by Viral Onset of POTS
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Postural Tachycardia Syndrome (POTS)Experimental Treatment2 Interventions
Patients with postural tachycardia syndrome; patients will receive both IV phenylephrine and IV isoproterenol
Group II: Healthy (control) SubjectsExperimental Treatment2 Interventions
Healthy volunteers that are gender and age-matched (by groups) to the POTS patients; healthy subjects will receive both IV phenylephrine and IV isoproterenol
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Phenylephrine
2014
Completed Phase 4
~2040
Isoproterenol
2015
Completed Phase 3
~22740

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
805 Previous Clinical Trials
883,907 Total Patients Enrolled
8 Trials studying Postural Orthostatic Tachycardia Syndrome
538 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
Satish R Raj, MD, MSCIPrincipal InvestigatorUniversity of Calgary
4 Previous Clinical Trials
162 Total Patients Enrolled
2 Trials studying Postural Orthostatic Tachycardia Syndrome
58 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
~4 spots leftby Dec 2024
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