Deep Brain Stimulation
Deep Brain Stimulation for Chronic Pain
This trial tests a new type of brain stimulation device for people with chronic pain that doesn't respond to other treatments. The device sends electrical signals to different parts of the brain and adjusts these signals based on real-time pain levels. The goal is to provide better and longer-lasting pain relief.
Non-invasive Brain Stimulation
TMS for Complex Regional Pain Syndrome
This trial is testing a new method that uses magnetic pulses to influence brain activity. It aims to help people with a difficult-to-treat chronic pain condition by reducing pain and improving symptoms. This method has been used in various conditions, including depression, Parkinson's disease, Alzheimer's disease, and chronic pain.
Opioid Antagonist
LDN for Complex Regional Pain Syndrome
This trial is testing whether low-dose naltrexone can help relieve symptoms of complex regional pain syndrome. Participants will be given either LDN or a placebo for a few weeks, and will be asked to come in for several visits, which will include tests, physical assessments, and questionnaires.
Neurostimulation
Peripheral Neurostimulation for Complex Regional Pain Syndrome
This trial aims to investigate whether using electrical stimulation during nerve blocks can improve the quality of the block beyond just helping to find the right nerve. Nerve blocks are commonly used during surgery and for pain relief
Cannabinoid
CBD Cannabis Extract for Complex Regional Pain Syndrome
This trial aims to study how cannabinoids can help relieve pain in complex regional pain syndrome (CRPS). They will use various tests to see how cannabinoids affect pain and inflammation in patients with CRPS. The
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Trials for CRPS Patients
Spinal Cord Stimulation
Spinal Cord Stimulation for Complex Regional Pain Syndrome
This trial aims to see if using a closed-loop spinal cord stimulator early on in complex regional pain syndrome treatment is more effective than using it in the later stages.
NMDA Receptor Antagonist
Ketamine Tablets for Complex Regional Pain Syndrome
This trial aims to test the safety and effectiveness of Ketamine HCl Prolonged Release tablets in people with complex regional pain syndrome. It will also assess how well participants follow the dosing instructions
Ultrasound Therapy
LIFU for Chronic Pain
This trial is testing a new therapy called low-intensity focused ultrasound (LIFU) for people with chronic pain conditions like CRPS and FM. LIFU uses gentle sound waves to target specific brain areas to help reduce pain. The study aims to see if this therapy can lower pain levels and improve other symptoms in these patients.
Procedure
Nerve Block + Physiotherapy for Complex Regional Pain Syndrome
This trial aims to test a new treatment for adults with Complex Regional Pain Syndrome (CRPS), a severe chronic pain condition. The treatment involves an injection near the shoulder to block pain signals, followed by a program of physical exercises. Researchers hope this combination will be more effective than exercises alone in reducing pain and improving function.
Trials With No Placebo
Spinal Cord Stimulation
Spinal Cord Stimulation for Complex Regional Pain Syndrome
This trial aims to see if using a closed-loop spinal cord stimulator early on in complex regional pain syndrome treatment is more effective than using it in the later stages.
NMDA Receptor Antagonist
Ketamine Tablets for Complex Regional Pain Syndrome
This trial aims to test the safety and effectiveness of Ketamine HCl Prolonged Release tablets in people with complex regional pain syndrome. It will also assess how well participants follow the dosing instructions
Procedure
Nerve Block + Physiotherapy for Complex Regional Pain Syndrome
This trial aims to test a new treatment for adults with Complex Regional Pain Syndrome (CRPS), a severe chronic pain condition. The treatment involves an injection near the shoulder to block pain signals, followed by a program of physical exercises. Researchers hope this combination will be more effective than exercises alone in reducing pain and improving function.
Behavioural Intervention
Virtual Reality Therapy for Complex Regional Pain Syndrome
This trial tests if using VR goggles can help people with chronic pain from CRPS by distracting them with a virtual world and teaching them relaxation techniques. Virtual reality (VR) has shown promising results for pain management, including chronic pain.
Frequently Asked Questions
Introduction to complex regional pain syndrome
What are the top hospitals conducting complex regional pain syndrome research?
Complex regional pain syndrome (CRPS) is a debilitating condition that affects a patient's nervous system, causing severe and chronic pain. In the quest for effective treatments and interventions, several top hospitals are leading the way in conducting clinical trials dedicated to CRPS. Stanford University, situated in Palo Alto and Stanford, has emerged as a frontrunner with its ongoing commitment to addressing this complex and challenging disorder. Currently, they have two active trials focused on CRPS, building upon their previous two studies since undertaking their initial trial in 2015. Meanwhile, the University of Washington in Seattle has made notable strides by exclusively offering clinical trials specifically tailored to CRPS patients; their dedication includes an ongoing trial and one previously conducted study starting from 2022.
Furthermore, groundbreaking efforts can be witnessed at the Fralin Biomedical Research Institute located in Roanoke where they are actively pursuing one trial targeting complex regional pain syndrome while also having completed another investigation since initiating research endeavors into this condition just last year—2023.Though relatively new to the field compared to other institutions mentioned here,the UCSF Medical Center based out of San Francisco showcases equal determination with its present-day engagement in an ongoing clinical trial alongside gainful utilization of opportunities provided by their past singular investigations beginning from 2022 onwards.
These hospitals' unwavering dedication towards advancing our understanding of CRPS demonstrates a commitment to improving the lives of those living with this excruciating condition. By pioneering innovative approaches through rigorous scientific investigations,collaborating across specialties,and employing cutting-edge technologies these institutions endeavor not only provide much-needed relief but also strive toward finding long-lasting solutions for a better quality life for individuals battling Complex Regional Pain Syndrome
Which are the best cities for complex regional pain syndrome clinical trials?
When it comes to clinical trials for complex regional pain syndrome, several cities are leading the way in research and treatment options. Palo Alto, California and San Francisco, California both have 2 active trials each, focusing on interventions such as Empowered Relief for Youth, LDN, High Frequency rTMS, Active DBS. Additionally, Stanford University in California has 1 active trial investigating treatments like Ketamine and Midazolam. Seattle in Washington also has 1 ongoing trial exploring Roosevelt "in Clinic VR" + "VR homeworks". Finally, Roanoke in Virginia offers 1 active trial studying LIFU - CRPS. These cities serve as hubs of innovation and provide individuals with complex regional pain syndrome access to cutting-edge clinical trials that offer hope for improved outcomes and relief from their condition.
Which are the top treatments for complex regional pain syndrome being explored in clinical trials?
Clinical trials exploring treatments for complex regional pain syndrome (CRPS) have identified two top contenders. First on the list is Empowered Relief for Youth, which has shown promise in its ongoing trial specifically targeting CRPS. Introduced in 2023, this treatment aims to provide relief and improvement for young patients suffering from this debilitating condition. Another contender making waves is High Frequency rTMS, with an active trial dedicated to investigating its effectiveness against CRPS. This innovative therapy was first listed in 2022 and holds potential as a non-invasive option for managing the symptoms of CRPS. As research progresses, these treatments offer hope for individuals living with the burdensome challenges of CRPS.
What are the most recent clinical trials for complex regional pain syndrome?
In the realm of complex regional pain syndrome (CRPS), recent clinical trials have focused on exploring the potential benefits of ketamine and midazolam. In a Phase 2 trial, these medications are being investigated for their effectiveness in alleviating the symptoms associated with CRPS. By targeting and managing the unique challenges posed by this condition, researchers aim to enhance patient outcomes and provide relief from chronic pain. With ongoing studies delving into innovative treatment approaches, there is hope for improved quality of life for individuals battling CRPS.
What complex regional pain syndrome clinical trials were recently completed?
Recently completed clinical trials have made significant progress in the field of complex regional pain syndrome (CRPS). These trials aimed to enhance our understanding and develop improved treatments for this debilitating condition. One notable trial was sponsored by the National Institute of Neurological Disorders and Stroke, which explored new therapeutic approaches and concluded recently. Another important study, conducted by Johns Hopkins University School of Medicine, examined the effectiveness of a novel intervention technique on CRPS symptoms. These successful advancements offer hope to individuals living with CRPS and highlight the ongoing efforts to find better solutions for managing this challenging condition.