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Nicotine Replacement Therapy

E-Cigarettes + Nicotine Patch for Nicotine Addiction

N/A
Recruiting
Led By Amy C Janes, PhD
Research Sponsored by Mclean Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be aged 18-45.
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks after use
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to find out if using electronic cigarettes can help people become less sensitive to things that make them want to smoke.

Who is the study for?
This trial is for individuals aged 18-45 who smoke cigarettes daily, have a carbon monoxide level indicating regular smoking, and show some nicotine dependence. Participants must be willing to use Nicotine Replacement Therapy and e-cigarettes for 2-3 weeks, speak English, and pass an MRI safety screening.
What is being tested?
The study aims to see if using both nicotine patches and electronic cigarettes can help reduce the urge to smoke when exposed to cues related to smoking. It involves monitoring reactions during an MRI scan.
What are the potential side effects?
Potential side effects may include irritation from the nicotine patch or e-cigarette use such as throat/mouth discomfort or skin reactions at the patch site. The impact of dual usage on cravings or withdrawal symptoms will also be observed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 45 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks after use
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks after use for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Reduction in Cue Reactivity

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Dual nicotine patch and electronic cigaretteExperimental Treatment1 Intervention
Nicotine patch and the electronic cigarette will be administered.

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Who is running the clinical trial?

Mclean HospitalLead Sponsor
217 Previous Clinical Trials
22,068 Total Patients Enrolled
Amy C Janes, PhDPrincipal InvestigatorMclean Hospital
~10 spots leftby Dec 2025
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