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Dextrose + Washout versus Normal Saline for Urinary Tract Infection

N/A
Waitlist Available
Led By Jeffrey Cornella, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6-9 days post-operative

Summary

This trial will compare UTI rates in patients who had hysterectomy with two different bladder washout solutions. Results will measure UTI rates 6-9 days after surgery.

Who is the study for?
This trial is for patients scheduled for hysterectomy without a history of diabetes, chronic kidney disease, or recurrent UTIs. It excludes those with ureteral injury, chronic immunosuppression, renal anomalies, and anyone who needs an indwelling catheter for more than 24 hours post-surgery.
What is being tested?
The study compares the effectiveness of using 50% dextrose injection plus bladder washout versus normal saline in preventing urinary tract infections after a hysterectomy. The main focus is on the number of UTIs occurring within 6-9 days post-operation.
What are the potential side effects?
Potential side effects may include discomfort from the cystoscopy fluid used during surgery. Specific side effects related to the use of dextrose or saline will be monitored and compared between groups.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6-9 days post-operative
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6-9 days post-operative for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
rates of urinary tract infections at 6-9 days post-operative

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: 50% dextroseActive Control1 Intervention
Cystoscopic distention of 40 cc of 50% dextrose plus 300 cc of normal saline washout
Group II: Normal SalinePlacebo Group1 Intervention
Cystoscopic distention media of normal saline.

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,339 Previous Clinical Trials
3,062,005 Total Patients Enrolled
3 Trials studying Hysterectomy
170 Patients Enrolled for Hysterectomy
Jeffrey Cornella, MDPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials
4 Total Patients Enrolled
Johnny Yi, MDPrincipal InvestigatorMayo Clinic
2 Previous Clinical Trials
30 Total Patients Enrolled

Media Library

50% dextrose Clinical Trial Eligibility Overview. Trial Name: NCT03719755 — N/A
Hysterectomy Research Study Groups: 50% dextrose, Normal Saline
Hysterectomy Clinical Trial 2023: 50% dextrose Highlights & Side Effects. Trial Name: NCT03719755 — N/A
50% dextrose 2023 Treatment Timeline for Medical Study. Trial Name: NCT03719755 — N/A
~2 spots leftby Dec 2024
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