Dextrose + Washout versus Normal Saline for Urinary Tract Infection

Palo Alto (17 mi)

Overseen byJeffrey Cornella, MD

Age: Any Age

Sex: Female

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Mayo Clinic

Trial Summary

What is the purpose of this trial?Our study will compare the rates of postoperative urinary tract infections (UTI) between patients who undergo cystoscopy using 50% dextrose injection plus bladder washout versus normal saline after hysterectomy for benign indications. Primary outcome will be rates of urinary tract infections at 6-9 days post-operatively. This will be defined as a urine culture yielding greater than 100,000 gram-negative colony-forming units per milliliter.

Eligibility Criteria

This trial is for patients scheduled for hysterectomy without a history of diabetes, chronic kidney disease, or recurrent UTIs. It excludes those with ureteral injury, chronic immunosuppression, renal anomalies, and anyone who needs an indwelling catheter for more than 24 hours post-surgery.

Treatment Details

The study compares the effectiveness of using 50% dextrose injection plus bladder washout versus normal saline in preventing urinary tract infections after a hysterectomy. The main focus is on the number of UTIs occurring within 6-9 days post-operation.

2Treatment groups

Active Control

Placebo Group

Group I: 50% dextroseActive Control1 Intervention

Cystoscopic distention of 40 cc of 50% dextrose plus 300 cc of normal saline washout

Group II: Normal SalinePlacebo Group1 Intervention

Cystoscopic distention media of normal saline.