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Exercise Training for Mental Illness

N/A
Recruiting
Led By Ryan Garten, PhD
Research Sponsored by Virginia Commonwealth University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease
Be between 18 and 65 years old
Must not have
Taking medications that could influence cardiovascular function
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to the end of the final visit, about 14 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial will test the effects of different types of exercise on blood vessel function in people with and without mental health disorders.

Who is the study for?
This trial is for healthy individuals and those with PTSD or GAD who have specific scores on mental health scales. It's not for pregnant women, current/recent smokers, people with limited English proficiency, those on certain cardiovascular meds, drug/alcohol users, or anyone on a significant calorie restriction.
What is being tested?
The study is testing the effects of two types of exercise training—muscular fitness and strength training—on blood vessel function in both healthy participants and those with PTSD or GAD.
What are the potential side effects?
While the trial involves exercise interventions that are generally safe, potential side effects may include muscle soreness, fatigue, joint pain or injury from physical activity.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am healthy with no obvious heart, lung, or metabolic diseases.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am on medication that affects my heart's health.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to the end of the final visit, about 14 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to the end of the final visit, about 14 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Arm Vascular Function at Rest (Flow Mediated Dilation Test)
Arm Vascular Function in Response to Exercise (Handgrip Exercise Test)
Leg Vascular Function (Passive Leg Movement Test)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Muscular fitnessExperimental Treatment1 Intervention
Participants will complete study 1 (HM20020955-1) and then 10 weeks of resistance training for muscular fitness
Group II: Muscular StrengthExperimental Treatment1 Intervention
Participants will complete study 1 (HM20020955-1) and then 10 weeks of resistance training for muscular strength

Find a Location

Who is running the clinical trial?

Virginia Commonwealth UniversityLead Sponsor
715 Previous Clinical Trials
22,888,215 Total Patients Enrolled
Ryan Garten, PhDPrincipal InvestigatorVirginia Commonwealth University
5 Previous Clinical Trials
1,187 Total Patients Enrolled

Media Library

Muscular Fitness Training Group Clinical Trial Eligibility Overview. Trial Name: NCT04916340 — N/A
~64 spots leftby Nov 2025
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