Nicotinamide Riboside Malate for Vascular Stiffness
(NRM Trial)

Recruiting in Palo Alto (17 mi)

Overseen byBrent Bauer, MD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Mayo Clinic

Trial Summary

What is the purpose of this trial?

The purpose of this study is to better understand the effects of nicotinamide riboside supplement in overall cardiovascular health in healthy adults.

Eligibility Criteria

This trial is for healthy adults aged 40-60 who are not pregnant, nursing, or trying to conceive. Participants must understand and agree to the study's procedures without any chronic diseases, unstable medical conditions, severe obesity, or recent use of certain natural health products.

Inclusion Criteria

Not pregnant at time of consent

Provides consent to participate in the study

Understands and agrees to follow all study procedures and limitations

See 2 more

Exclusion Criteria

An unstable medical or mental health condition as determined by the physician investigator

BMI less than 30

Pregnant, nursing, or trying to conceive

See 7 more

Treatment Details

Interventions

Nicotinamide Riboside Malate (Vitamin Supplement)

Trial OverviewThe trial is testing the effects of a supplement called Nicotinamide Riboside Malate on cardiovascular health in comparison with a placebo. The goal is to see if this supplement can improve vascular function in healthy individuals.

Participant Groups

3Treatment groups

Active Control

Placebo Group

Group I: 830 mg Nicotinamide and PlaceboActive Control2 Interventions

830 mg Nicotinamide supplement capsule and 1 identical Placebo capsule twice a day for 12 weeks

Group II: 1660 mg NicotinamideActive Control1 Intervention

1660 mg Nicotinamide supplement; 2 of the 830 mg capsules twice a day for 12 weeks

Group III: PlaceboPlacebo Group1 Intervention

2 identical Placebo capsules twice a day for 12 weeks