Monoclonal Antibodies
Foselutoclax for Diabetic Macular Edema
This trial is testing foselutoclax, a new drug, in patients with Diabetic Macular Edema who haven't responded to other treatments. The drug works by blocking a protein to reduce eye swelling and improve vision.
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Trials for DR Patients
Artificial Intelligence
AI Screening for Diabetic Retinopathy
"This trial will test if an artificial intelligence algorithm called NeoRetina, created by DIAGNOS Inc., can accurately detect and grade the severity of diabetic retinopathy by analyzing eye fundus photographs."
Fibrate
Fenofibrate for Diabetic Retinopathy
This trial will compare the effect of fenofibrate (a drug used to treat high cholesterol) to placebo for preventing diabetic retinopathy (a disease that affects the retina) from getting worse. The trial will also assess the relationship of glycemic variability (how much blood sugar levels fluctuate) with diabetic retinopathy outcomes.
Nonsteroidal Anti-inflammatory Drug
Ketorolac Eye Drops for Diabetic Retinopathy
This trial tests if regular use of ketorolac eye drops can reduce inflammation and slow down or prevent the worsening of Diabetic Retinopathy in adults with type II diabetes. Ketorolac has been shown to be effective in reducing inflammation and symptoms associated with eye allergies and after surgery.
Trials for Blindness Patients
Noninvasive Brain Stimulation
Brain Stimulation + Visual Training for Stroke-Related Vision Impairment
This trial tests a new treatment for stroke patients who have lost part of their vision. The treatment combines visual exercises with gentle electrical brain stimulation to help improve vision. The goal is to see if this approach can help the brain recover and restore some lost vision.
Behavioural Intervention
Multi-sensory Rehabilitation for Low Vision
"This trial aims to improve vision rehabilitation for people with severe visual impairment by testing a new approach that involves multiple senses. Many clinical trials are recruiting participants with advanced eye diseases, but the best rehabilitation plan after
Stem Cell Therapy
Stem Cell Therapy for Retinal and Optic Nerve Disorders
This trial will use stem cells from patients' own bone marrow to treat severe vision loss caused by retinal or optic nerve damage. The stem cells will be injected into the eye to help repair the damaged tissues. SCOTS is the largest ophthalmology stem cell study registered at the National Institutes of Health, using autologous bone marrow-derived stem cells for retinal and optic nerve diseases.
Texture Changing Coatings for Low Vision and Blindness
"This trial proposes a new no-power testing platform that allows people with low vision or blindness to receive test results through a texture change that they can feel by touch. This technology aims to promote independence and privacy
Behavioral Intervention
Tactile Aids for Blindness
This trial aims to improve tactile aids by using materials chemistry to create tactile sensations instead of physical bumps or textures. The study will test how well low vision or blind individuals can identify objects with these new tactile
Trials With No Placebo
Artificial Intelligence
AI Screening for Diabetic Retinopathy
"This trial will test if an artificial intelligence algorithm called NeoRetina, created by DIAGNOS Inc., can accurately detect and grade the severity of diabetic retinopathy by analyzing eye fundus photographs."
Stem Cell Therapy
Stem Cells for Retinal Disease
This trial is testing if injecting special cells from bone marrow into the eye is safe and possible for patients who are permanently blind due to retinal diseases. The hope is that these cells can help fix the damaged parts of their eyes.
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Frequently Asked Questions
Introduction to diabetic retinopathy
What are the top hospitals conducting diabetic retinopathy research?
In the realm of diabetic retinopathy, several hospitals are leading the charge in innovative clinical trials. Austin Retina Associates, located in Austin, stands at the forefront with six ongoing trials dedicated to this condition and a total of 11 completed studies thus far. Remarkably, their first recorded trial took place in 2012—an impressive testament to their commitment to advancing research on diabetic retinopathy. Moving westward to Bakersfield, California Retina Consultants is making significant strides as well. With four active trials and seven overall studies related to diabetic retinopathy under their belt since initiating their first trial in 2017, they have established themselves as key players in this field.
On the East Coast, Lynchburg's Piedmont Eye Center has emerged as another important institution for conducting clinical trials on diabetic retinopathy. Currently engaged in three active trials and boasting four previous studies dating back only a year ago when they conducted their inaugural investigation; it demonstrates increasing interest from both patients and researchers alike.
Further south, Palmetto Retina Center based out of West Columbia also focuses its efforts on combating diabetic retinopathy through three ongoing trials while contributing five comprehensive investigations since starting its medical journey just half a decade ago during 2016. Finally among these distinguished institutions is Bellaire's Retina Consultants of Texas where experts work diligently towards finding solutions for those affected by this debilitating eye disease.Headlining three current tests whilst having accumulated six compiled projects already within less than one year span; It showcases how committed these institutions are towards resolving any caught impacts due to Diabetic Retinoparthy
These hospitals serve as beacons of hope for individuals grappling with issues relating to vision loss caused by diabetes-related complications. By dedicating resources and expertise toward understanding better treatments or potential cure options through rigorous clinical research;they strive tirelessly every day.Constant evolution driven by relentless pursuit leads us closer than ever before - revealing promising future prospects that will enhance the quality of life for countless individuals affected by diabetic retinopathy throughout the globe.
Which are the best cities for diabetic retinopathy clinical trials?
When it comes to clinical trials for diabetic retinopathy, several cities have emerged as key players in research and development. Austin, Texas leads the pack with 15 ongoing trials focusing on treatments like Fenofibrate, Runcaciguat (BAY1101042), and OPL-0401 Dose 1. San Antonio, Texas follows closely behind with 11 active studies investigating interventions such as OTT166 and KSI-301. Lastly, Hagerstown, Maryland showcases its commitment to advancing care through 10 active trials studying Runcaciguat (BAY1101042), RGX-314 Dose 2, and other potential treatment options. These cities provide individuals with diabetic retinopathy access to cutting-edge clinical trials that may pave the way for improved management of this condition.
Which are the top treatments for diabetic retinopathy being explored in clinical trials?
Clinical trials investigating treatments for diabetic retinopathy have identified two top contenders. Financial Incentive, introduced in 2016, has shown promise and is currently being tested in two active trials dedicated to diabetic retinopathy. Another potential treatment is Sinemet CR, which made its debut in 2022 and is the focus of one ongoing trial specifically targeting this condition. These innovative therapies offer hope for improved management and outcomes for individuals affected by diabetic retinopathy.
What are the most recent clinical trials for diabetic retinopathy?
Exciting developments in the field of diabetic retinopathy research offer hope for improved treatment options. Recent clinical trials have explored various approaches to address this condition. One trial, known as 4D-150 Part 1 Dose Confirmation, focused on determining the appropriate dosage for treating diabetic retinopathy. Another study investigated the efficacy of foselutoclax as a potential treatment option. Additionally, Phase 2 Cohort B and Group 1 trials aimed to evaluate different interventions for managing diabetic retinopathy. Lastly, an innovative therapy called OTX-TKI underwent Phase 1 testing with promising results. These ongoing trials signify significant progress towards enhancing care and outcomes for individuals affected by diabetic retinopathy.
What diabetic retinopathy clinical trials were recently completed?
Recently, several clinical trials for diabetic retinopathy have concluded, bringing new insights and potential treatments to the forefront. In July 2021, Boehringer Ingelheim completed a trial examining the efficacy of BI 765128 in this condition. Ocuphire Pharma also made significant progress with their APX3330 trial, finishing in April 2021. Previous breakthroughs include Boehringer Ingelheim's completion of the BI 764524 trial in June 2020 and Hoffmann-La Roche's RG7774 trial concluding around the same time. Additionally, Adverum Biotechnologies successfully wrapped up their Aflibercept study in May 2020. These studies represent crucial milestones towards improving outcomes for individuals affected by diabetic retinopathy.