Popular Trials
Menadione Lotion for Cancer-Related Skin Discomfort
This trial studies a menadione lotion to help cancer patients with skin discomfort and distress from their treatments. The lotion is applied to the skin to soothe and protect it, aiming to reduce rashes and pain. Menadione, also known as vitamin K3, has been studied for its potential to activate certain skin receptors and reduce skin rashes caused by cancer treatments.
Regional Anesthesia for Broken Arm
This trial is testing if a numbing injection near the collarbone can better control pain in children aged 4-12 who have specific elbow fractures and need surgery. The injection blocks pain signals from the arm to the brain. The goal is to see if this method reduces the need for pain medicine after surgery.
Monoclonal Antibodies
Denosumab for Fibrous Dysplasia
This trial is testing denosumab, a drug that helps strengthen bones, in adults with fibrous dysplasia, a condition where bones grow abnormally. Denosumab works by stopping the cells that break down bone tissue, aiming to reduce bone pain and improve bone strength.
Procedure
Sociocultural Influences on Pain Assessment
This trial is exploring if social and cultural factors play a role in how people experience pain and how others interpret it. Eligible participants will be asked to complete a series of tests that may include electric shock, thermal stimulation, and viewing images of others in pain.
Local Anesthetic
Varied Lidocaine Injection Methods for Pain Management
This trial will collect data from multiple academic institutions to study the effect of anesthetic injection rate and temperature on pain perception during dermatologic procedures, as well as if buffering the anesthetic solution alters pain perception.
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Trials for Pain Patients
Procedure
Nerve Block Timing for Shoulder Pain
This trial is testing a procedure where pain medication is injected near neck nerves to manage pain after shoulder surgery. It targets healthy adolescents having shoulder reconstruction. The treatment works by numbing the nerves to block pain signals, helping reduce the need for other painkillers and speeding up recovery. This method has been found to be the most effective way to control pain after shoulder surgery.
Trials for Anxiety Patients
Cannabinoid
Cannabis for Cancer-Related Symptoms
This trial will test the effectiveness of three cannabis oil extract combinations (High THC-Low CBD, Low THC-High CBD, or Equal amounts of THC and CBD) in a minimum of 120 cancer patients on 4 cancer-related symptoms: nausea, pain, anxiety and sleep disturbance.
VR Therapy for Pain and Anxiety During Medical Procedures
This trial tests if VR can reduce pain and anxiety in children aged 7-21 during medical procedures by distracting them with a virtual world. The study compares the effectiveness of using VR versus not using VR. Virtual reality (VR) has been shown to decrease pain and anxiety in children undergoing various medical procedures.
Virtual Reality for Pain Management During Anesthesia
This trial tests if using VR headsets showing calming scenes can help reduce pain and anxiety in patients aged 18-64 at Cedars-Sinai Medical Center during regional anesthesia. By distracting patients, VR may make them feel less pain and stress. Advancements in virtual reality (VR) technology have resulted in its expansion into health care.
Behavioral Intervention
Acceptance and Commitment Therapy for Postoperative Pain After Knee Replacement
This trial is testing whether Acceptance and Commitment Therapy (ACT) is more effective than Attention Control (AC) in reducing postoperative pain and improving functioning in at-risk Veterans undergoing total knee arthroplasty (TKA).
Phase 3 Trials
Opioid Analgesic
Pain Medication for Postoperative Pain
This trial is testing whether adding Toradol, an anti-inflammatory drug, to the usual opioid painkillers can better manage pain after surgery in patients who have had a specific type of bone surgery. These patients are chosen because they don't need the body's natural inflammation process for healing. Toradol works by reducing inflammation, while opioids change how the brain perceives pain. Toradol, also known as ketorolac, is a nonsteroidal anti-inflammatory drug (NSAID) that has been studied for its opioid-sparing effects in postoperative pain management.
Behavioral Intervention
Acceptance and Commitment Therapy for Postoperative Pain After Knee Replacement
This trial is testing whether Acceptance and Commitment Therapy (ACT) is more effective than Attention Control (AC) in reducing postoperative pain and improving functioning in at-risk Veterans undergoing total knee arthroplasty (TKA).
Corticosteroid
PRP vs Corticosteroid Injections for Shoulder Osteoarthritis
This trial investigates LP-PRP injections for young active duty and civilian patients with shoulder osteoarthritis. The treatment uses concentrated platelets from the patient's own blood to promote healing and reduce inflammation, aiming to improve pain and function without surgery. This method has shown potential in treating various inflammatory and degenerative conditions by modulating the inflammatory environment and promoting tissue repair.
Trials With No Placebo
Procedure
Nerve Block Timing for Shoulder Pain
This trial is testing a procedure where pain medication is injected near neck nerves to manage pain after shoulder surgery. It targets healthy adolescents having shoulder reconstruction. The treatment works by numbing the nerves to block pain signals, helping reduce the need for other painkillers and speeding up recovery. This method has been found to be the most effective way to control pain after shoulder surgery.
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Frequently Asked Questions
Introduction to pain
What are the top hospitals conducting pain research?
When it comes to advancing our understanding and treatment of pain, several top hospitals are leading the charge. In Brooklyn, Maimonides Medical Center has made significant strides with three ongoing pain trials and a total of 18 completed studies in this field. Their first recorded pain trial took place in 2013, showcasing their commitment to staying at the forefront of pain research. The renowned Mayo Clinic in Rochester is also making impressive contributions with three active pain trials and a track record of 19 past studies since initiating their first trial in 2005.
Meanwhile, Vanderbilt University Medical Center in Nashville focuses on addressing pain through two ongoing clinical trials and seven previously conducted ones since embarking on their inaugural study back in 2003. Brigham and Women's Hospital, located in Boston, shares a similar dedication by currently conducting two active pain trials while having an accomplished history of 16 previous investigations dating back to their first recorded trial in 2001.
Lastly, the University of Florida based in Gainesville plays a crucial role as well with its involvement in two current pain trials and twelve prior studies that began with their inaugural investigation taking place alongside Mayo Clinic’s initial effort both during the year -2005.
These esteemed institutions highlight not only the importance but also the complexity surrounding chronic pain management. Through collaborative efforts like these clinical trials across various locations nationwide we can move closer towards finding better solutions for those suffering from chronic or acute forms of this condition; ensuring improved quality of life for patients everywhere
Which are the best cities for pain clinical trials?
When it comes to pain clinical trials, several cities emerge as top destinations for cutting-edge research. New york, New York leads the way with 9 active trials focusing on various treatments like Pain Evaluation and BPISF, Non-stiff Intravenous Hydrocortisone, and Sana Pain Reliever. Indianapolis, Indiana follows closely behind with 8 ongoing studies exploring different treatment approaches. Toronto, Ontario also ranks high in the list with 7 active trials investigating potential treatments like Group 3 and Cryoneurolysis Group. These cities offer individuals suffering from chronic pain access to innovative clinical trials that may lead to improved management and relief.
Which are the top treatments for pain being explored in clinical trials?
In the realm of pain management, clinical trials are exploring a range of treatments to alleviate discomfort. Topping the list is the promising Acetaminophen/Naproxen Sodium Fixed Combination, currently being tested in two active trials dedicated to pain relief. A newcomer on the scene, Intranasal Fentanyl (2 mcg/kg), shows promise in its first listed trial for providing effective pain control. Another contender making waves is 10 mL 2% lidocaine, with one ongoing trial showcasing its potential as a treatment option. As researchers delve deeper into these innovative approaches, they bring us closer to finding improved solutions for managing and reducing pain effectively.
What are the most recent clinical trials for pain?
Recent clinical trials have brought new possibilities in the realm of pain management. One notable study examined the efficacy of EMLA Cream, which has shown promising results in alleviating pain. Additionally, a phase 4 trial explored the use of ABC block with bupivacaine and liposomal bupivacaine as a potential solution for pain relief. Another trial focused on the benefits of acetaminophen/naproxen sodium fixed combination in managing pain. Lastly, an investigation into oral immediate-release oxycodone 10mg offers insights into its effectiveness as a treatment option for pain management. These ongoing studies offer hope and advancements to address various types and causes of physical discomfort effectively.
What pain clinical trials were recently completed?
Recent advancements in pain management research have yielded valuable insights through the completion of various clinical trials. Notably, a study sponsored by the University of Wisconsin, Madison concluded in October 2021, examining the efficacy of Liposomal bupivacaine. In September 2021, NorthShore University HealthSystem successfully completed a trial investigating low-dose naltrexone. Additionally, an investigation into Mindfulness conducted by the University of California, San Diego came to fruition in January 2021. These studies contribute to our understanding of pain treatment and pave the way for potential breakthroughs that could enhance patients' quality of life.