Biguanide
Metformin for Prediabetes
This trial is testing whether metformin can lower the risk of death, heart attacks, and strokes in people with pre-diabetes and heart or blood vessel issues. Metformin is a drug that helps control blood sugar levels and has been used to treat type 2 diabetes mellitus for more than 60 years. The study involves patients who have pre-diabetes and existing heart or blood vessel problems, aiming to see if metformin can provide additional health benefits.
Behavioural Intervention
Lifestyle Intervention for Preventing Type 2 Diabetes
This trial aims to study a new program to prevent type 2 diabetes in adults in the US. The program focuses on lifestyle changes and support from romantic partners to create long-lasting effects.
Behavioral Intervention
Heat Therapy for Prediabetes
This trial aims to determine if using heat pads on the legs can improve muscle health, physical function, and blood sugar control in older individuals with prediabetes as effectively as High-Intensity Interval Training (
Hormone Therapy
Insulin Management for Non-alcoholic Fatty Liver Disease
"This trial aims to study the effects of lowering insulin levels on liver glucose production and fat synthesis in individuals with insulin resistance and fatty liver disease. Participants will undergo two procedures with different insulin levels to compare the
Behavioural Intervention
Time-Restricted Eating for Type 2 Diabetes
This trial studies the effects of timing of eating on blood sugar in those with obesity and type 2 diabetes. Participants are assigned a 4-12hr eating window with no restrictions on the food they eat. Results will compare 3 9hr windows to determine if start and stop time impacts blood sugar.
Popular Filters
Trials for Incretin Hormones In Polycystic Ovary Syndrome Patients
Behavioral Intervention
Small Steps for Big Changes Program for Prediabetes
This trial evaluates the effectiveness of the 'Small Steps for Big Changes' (SSBC) program, designed to help people with prediabetes improve their diet and exercise habits. The goal is to see if these changes can lower blood sugar levels, reduce weight, and decrease waist size over time. Participants receive personalized guidance and support from trainers at YMCA locations. The 'Small Steps for Big Changes' (SSBC) program emphasizes behavior change techniques and motivational interviewing to help adults at risk for type 2 diabetes.
Potassium Channel Activator
Diazoxide for Non-alcoholic Fatty Liver Disease
This trial will compare 2 doses of diazoxide to placebo to see how they affect glucose and fat metabolism in people with IR-NAFLD. Participants will take 27 doses, have fasting blood tests and wear a glucose monitor for 14 days.
Sodium-glucose cotransporter 2 (SGLT2) inhibitor
Empagliflozin for Prediabetes
This trial is testing whether the drug empagliflozin can help improve regulation of blood sugar in overweight or obese adults with prediabetes. They will also be looking at possible mechanisms to explain how empagliflozin might improve metabolism in skeletal muscle.
Trials for Prediabetes Patients
Behavioral Intervention
Small Steps for Big Changes Program for Prediabetes
This trial evaluates the effectiveness of the 'Small Steps for Big Changes' (SSBC) program, designed to help people with prediabetes improve their diet and exercise habits. The goal is to see if these changes can lower blood sugar levels, reduce weight, and decrease waist size over time. Participants receive personalized guidance and support from trainers at YMCA locations. The 'Small Steps for Big Changes' (SSBC) program emphasizes behavior change techniques and motivational interviewing to help adults at risk for type 2 diabetes.
Potassium Channel Activator
Diazoxide for Non-alcoholic Fatty Liver Disease
This trial will compare 2 doses of diazoxide to placebo to see how they affect glucose and fat metabolism in people with IR-NAFLD. Participants will take 27 doses, have fasting blood tests and wear a glucose monitor for 14 days.
Sodium-glucose cotransporter 2 (SGLT2) inhibitor
Empagliflozin for Prediabetes
This trial is testing whether the drug empagliflozin can help improve regulation of blood sugar in overweight or obese adults with prediabetes. They will also be looking at possible mechanisms to explain how empagliflozin might improve metabolism in skeletal muscle.
Trials With No Placebo
Behavioral Intervention
Small Steps for Big Changes Program for Prediabetes
This trial evaluates the effectiveness of the 'Small Steps for Big Changes' (SSBC) program, designed to help people with prediabetes improve their diet and exercise habits. The goal is to see if these changes can lower blood sugar levels, reduce weight, and decrease waist size over time. Participants receive personalized guidance and support from trainers at YMCA locations. The 'Small Steps for Big Changes' (SSBC) program emphasizes behavior change techniques and motivational interviewing to help adults at risk for type 2 diabetes.
Behavioral Intervention
Exercise Training for Fat Metabolism in Postmenopausal Women
This trial will study how well resistance training improves fat metabolism in postmenopausal women with obesity and pre-diabetes, to see if it could help prevent type 2 diabetes.
Behavioral Intervention
Quality Improvement and Implementation Science for Mental and Physical Health in Women Veterans
This trial is testing two strategies to help support and sustain evidence-based practices for women Veterans in up to 20 VA facilities.
Frequently Asked Questions
Introduction to pre diabetes
What are the top hospitals conducting pre diabetes research?
When it comes to advancing our understanding and treatment of pre-diabetes, leading hospitals and research institutions are making significant strides in various locations. At Columbia University Irving Medical Center in New york, researchers have embarked on two active pre-diabetes trials, contributing to the growing body of knowledge surrounding this condition. Since recording their first trial in 2022, they have shown a commitment to exploring innovative approaches to identifying and managing pre-diabetes. Similarly, the VA Greater Los Angeles Healthcare System in West Los Angeles has established itself as an important hub for pre-diabetes research. With two ongoing trials and a history of two previous investigations since their inaugural study in 2021, they are actively working towards finding effective interventions for this increasingly prevalent condition.
In Canada's picturesque city Kelowna, the University of British Columbia is also dedicated to tackling pre-diabetes through cutting-edge clinical trials. Their current focus revolves around one active trial aimed at understanding the early stages of this metabolic disorder and developing strategies for prevention or intervention. This institution joined the efforts with its first recorded trial just recently in 2023.
Meanwhile, even smaller-scale organizations like the Amish Research Clinic located in Lancaster play a notable role by conducting vital studies on pre-diabetes management. They too possess an ongoing investigation alongside their sole prior experience which took place likewise during 2023.
Lastly but not leastly there exist Oregon State University situated within Corvallis where investigators continue pursuing solutions addressing pre diabetes challenges; presently engaged with one active test while having conducted one exploratory analysis previously commencing from as recent as 2022.The dedication shown by these institutions signifies that awareness about prediabetic conditions matters greatly; collectively contributing towards development effective methods ensuring those at risk receive utmost help necessary before escalating into full-blown diabetes thus ultimately improving public health outcomes globally
Which are the best cities for pre diabetes clinical trials?
When it comes to pre diabetes clinical trials, several cities have emerged as leading hubs for research. New york City stands out with 3 active trials focusing on treatments like Diazoxide oral suspension and Metformin XR. West Los Angeles, California, follows closely behind with 2 ongoing studies investigating interventions such as EBQI and Metformin XR. Salt Lake City, Utah also shows promise with its 2 active trials exploring Metformin XR and couple-based intervention approaches. While Kelowna in British Columbia and Lancaster in Pennsylvania each have 1 trial underway studying different treatments. These cities offer individuals at risk of developing diabetes access to cutting-edge research aimed at preventing or managing the condition more effectively.
Which are the top treatments for pre diabetes being explored in clinical trials?
Clinical trials exploring treatments for pre-diabetes have identified several promising options. Diazoxide oral suspension, at a dosage of 1 mg per kg per dose, has shown potential in one active trial and is the focus of one all-time pre-diabetes trial since its listing in 2023. Another notable contender is empagliflozin, which is being investigated in one active and one all-time pre-diabetes trial after its introduction in 2022. Resistance exercise has also gained attention with its inclusion in one ongoing trial and two previous pre-diabetes studies since it was first listed as a treatment option in 2019. These treatments offer hope for individuals at risk of progressing to full-fledged diabetes and may pave the way towards better management strategies for this condition.
What are the most recent clinical trials for pre diabetes?
Promising advancements are being made in the field of pre diabetes research, with recent clinical trials highlighting potential treatment options. The RE protocol demonstrates encouraging results for individuals with pre diabetes by aiming to reduce insulin levels through a phased approach. Another trial explores the use of diazoxide oral suspension at a specific dosage as a potential therapeutic option for pre diabetes patients. Additionally, Metformin XR and Empagliflozin have shown promise in managing pre diabetes symptoms, providing hope for improved outcomes in affected individuals. These cutting-edge studies offer optimism and may pave the way towards more effective interventions for those living with pre diabetes.
What pre diabetes clinical trials were recently completed?
Two notable clinical trials investigating potential interventions for pre-diabetes have reached completion, bringing hope for individuals at risk of developing type 2 diabetes. In October 2020, Indiana University concluded a trial examining the effectiveness of Antidepressant Medications in managing pre-diabetes. Similarly, Mayo Clinic wrapped up their study on Exenatide SR in May 2019. These recent advancements highlight ongoing efforts to identify ways to prevent or delay the progression from pre-diabetes to full-blown diabetes and ultimately improve outcomes for patients worldwide.