Opioid Partial Agonist
Buprenorphine + XR-Naltrexone for Opioid Use Disorder
Recruiting0 awardsPhase 2 & 3
New York, New York
This trial will compare the effectiveness of a new drug combination to treating opioid addiction with extended release naltrexone alone. It is a double-blind, placebo-controlled study, meaning neither the participants nor the researchers will know who is receiving the new treatment or the placebo. The study will last 24 weeks, during which participants will receive six injections of either the new treatment or a placebo. The study's goal is to see if the new treatment can improve treatment retention, reduce opioid craving, and improve mood.
Opioid Agonist
Buprenorphine/Naloxone Dosing Strategies for Opioid Use Disorder
Recruiting3 awardsPhase 2 & 3
Edmonton, Alberta
This trial will compare the effectiveness of two different regimens for taking buprenorphine/naloxone to treat opioid addiction. One group will take increasing doses of the medication until they reach an effective level, while the other group will take a standard dose.
Opioid Agonist
Comprehensive Support Program for Opioid Addiction
Recruiting3 awardsPhase 4
Houston, Texas
This trial is testing a new program to help youths with opioid use disorder in Houston. The program includes medication, counseling, and peer support. The goal is to see if this program can help engage and retain more people in treatment.
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Phase 3 Trials
Opioid Partial Agonist
Extended Release Buprenorphine for Opioid Use Disorder
Recruiting1 awardPhase 2 & 3
New Haven, Connecticut
This trial is testing whether a 28-day formulation of extended-release buprenorphine is more effective than usual treatment for patients with a moderate or severe opioid use disorder who are seen by an addiction consultation service and agree to start a medication for OUD.
Opioid Agonist
Buprenorphine for Opioid Addiction during Pregnancy
Recruiting2 awardsPhase 3
Jacksonville, Florida
This trial is testing whether an extended-release form of buprenorphine is as effective as the standard form in treating pregnant women with opioid use disorder, with the goal of improving outcomes for mother and child.
Trials With No Placebo
Opioid Partial Agonist
Extended Release Buprenorphine for Opioid Use Disorder
Recruiting1 awardPhase 2 & 3
New Haven, Connecticut
This trial is testing whether a 28-day formulation of extended-release buprenorphine is more effective than usual treatment for patients with a moderate or severe opioid use disorder who are seen by an addiction consultation service and agree to start a medication for OUD.
Opioid Partial Agonist
Buprenorphine for Opioid Use Disorder
Recruiting3 awardsPhase 2
Oakland, California
This trial will recruit patients with opioid use disorder who present to the emergency department, and compare the effectiveness of two different medication treatments for engaging them in formal addiction treatment 7 days later.
Opioid Agonist
Long-acting Buprenorphine vs. Naltrexone for Opioid Use Disorder
Recruiting3 awardsPhase 4
New Haven, Connecticut
This trial will compare the effectiveness of two medications used to treat opioid use disorder, extended-release buprenorphine (XR-B) vs. extended-release naltrexone (XR-NTX), among adults currently incarcerated in U.S. jails and prisons.
Opioid Agonist
Buprenorphine for Opioid Addiction during Pregnancy
Recruiting2 awardsPhase 3
Jacksonville, Florida
This trial is testing whether an extended-release form of buprenorphine is as effective as the standard form in treating pregnant women with opioid use disorder, with the goal of improving outcomes for mother and child.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.