Monoclonal Antibodies
Canakinumab + Spartalizumab for Renal Cell Carcinoma
This trial is testing a new cancer treatment involving two drugs, canakinumab and spartalizumab, to see if it is safe and effective. The trial will also assess the immune response to the treatment and the anti-tumor activity.
Cyclin-Dependent Kinase Inhibitor
NKT2152 + Palbociclib + Sasanlimab for Kidney Cancer
This trial is testing a new drug combination for patients with advanced kidney cancer who have already tried other treatments. The goal is to see if these drugs can work better together to stop cancer growth and help the immune system fight the disease.
Small Molecule
DFF332 + Combination Therapy for Renal Cell Carcinoma
This trial is testing a new drug called DFF332 in patients with advanced kidney cancer and other cancers with certain genetic mutations. The drug works by blocking a protein that helps the cancer grow.
Immunotherapy
BMS-986340 + Nivolumab/Docetaxel for Cancer
This trial tests a new drug, BMS-986340, alone and with other cancer treatments (nivolumab and docetaxel) in patients with advanced solid tumors. The goal is to find out if it is safe and effective in treating these cancers.
Popular Filters
Trials for Kidney Cancer Patients
HIF-2alpha Inhibitor
Belzutifan for Kidney Cancer
This trial is testing belzutifan, a medication for patients with advanced kidney cancer that hasn't responded to previous treatments. The drug works by blocking a protein that cancer cells need to grow. Researchers aim to find out if it is safe and effective for these patients. Belzutifan has received FDA approval for treating von Hippel-Lindau-associated renal cell carcinoma and has shown significant efficacy in related tumors.
Monoclonal Antibodies
Immune + Targeted Therapies for Renal Cell Carcinoma
This trial is a substudy of a larger study that is testing experimental treatments for renal cell carcinoma. The goal of this substudy is to see if the combination of investigational agents is safe and effective in people with advanced ccRCC.
Checkpoint Inhibitor
Immune and Targeted Combination Therapies for Kidney Cancer
This trial is studying new combinations of drugs to treat renal cell carcinoma. The goal is to find new ways to treat this disease that are more effective and have fewer side effects than current treatments.
HIF-2 Alpha Inhibitor
Belzutifan for Kidney Cancer
This trial will compare the effectiveness of two doses of belzutifan in people with advanced kidney cancer that has spread after previous treatment. The higher dose is expected to be better in terms of tumor shrinkage.
Trials for Kidney Cell Carcinoma Patients
HIF-2alpha Inhibitor
Belzutifan for Kidney Cancer
This trial is testing belzutifan, a medication for patients with advanced kidney cancer that hasn't responded to previous treatments. The drug works by blocking a protein that cancer cells need to grow. Researchers aim to find out if it is safe and effective for these patients. Belzutifan has received FDA approval for treating von Hippel-Lindau-associated renal cell carcinoma and has shown significant efficacy in related tumors.
Monoclonal Antibodies
Immune + Targeted Therapies for Renal Cell Carcinoma
This trial is a substudy of a larger study that is testing experimental treatments for renal cell carcinoma. The goal of this substudy is to see if the combination of investigational agents is safe and effective in people with advanced ccRCC.
Checkpoint Inhibitor
Immune and Targeted Combination Therapies for Kidney Cancer
This trial is studying new combinations of drugs to treat renal cell carcinoma. The goal is to find new ways to treat this disease that are more effective and have fewer side effects than current treatments.
HIF-2 Alpha Inhibitor
Belzutifan for Kidney Cancer
This trial will compare the effectiveness of two doses of belzutifan in people with advanced kidney cancer that has spread after previous treatment. The higher dose is expected to be better in terms of tumor shrinkage.
Phase 3 Trials
Kinase Inhibitor
Savolitinib vs. Sunitinib for Kidney Cancer
This trial is for patients with a certain type of kidney cancer that has spread and cannot be removed by surgery. The goal is to see if a new medication, savolitinib, is better than the current standard of care, sunitinib, and to learn about any side effects.
HIF-2 Alpha Inhibitor
Belzutifan + Pembrolizumab for Kidney Cancer
This trial is testing a new treatment in patients who have had kidney cancer surgery. The goal is to see if this treatment can prevent the cancer from coming back. One part of the treatment stops cancer cells from surviving in low oxygen, and the other part helps the immune system attack the cancer. This approach has shown improved survival rates in treating advanced kidney cancer.
Trials With No Placebo
HIF-2alpha Inhibitor
Belzutifan for Kidney Cancer
This trial is testing belzutifan, a medication for patients with advanced kidney cancer that hasn't responded to previous treatments. The drug works by blocking a protein that cancer cells need to grow. Researchers aim to find out if it is safe and effective for these patients. Belzutifan has received FDA approval for treating von Hippel-Lindau-associated renal cell carcinoma and has shown significant efficacy in related tumors.
Monoclonal Antibodies
Immune + Targeted Therapies for Renal Cell Carcinoma
This trial is a substudy of a larger study that is testing experimental treatments for renal cell carcinoma. The goal of this substudy is to see if the combination of investigational agents is safe and effective in people with advanced ccRCC.
Checkpoint Inhibitor
Immune and Targeted Combination Therapies for Kidney Cancer
This trial is studying new combinations of drugs to treat renal cell carcinoma. The goal is to find new ways to treat this disease that are more effective and have fewer side effects than current treatments.
HIF-2 Alpha Inhibitor
Belzutifan for Kidney Cancer
This trial will compare the effectiveness of two doses of belzutifan in people with advanced kidney cancer that has spread after previous treatment. The higher dose is expected to be better in terms of tumor shrinkage.
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Frequently Asked Questions
Introduction to renal cell carcinoma
What are the top hospitals conducting renal cell carcinoma research?
When it comes to cutting-edge clinical trials for renal cell carcinoma, several leading hospitals are making significant strides in finding new treatments and improving outcomes. In Houston, MD Anderson Cancer Center takes the lead with eight active trials dedicated to this type of kidney cancer and an impressive 24 completed trials since their first recorded study in 2003. Meanwhile, Massachusetts General Hospital in Boston is also at the forefront of research, currently conducting seven ongoing renal cell carcinoma trials and boasting a rich history of 35 previous studies dating back to their initial trial in 2007.
In New york City, researchers at Memorial Sloan Kettering Cancer Center have made substantial contributions as well. With seven ongoing clinical trials focused on renal cell carcinoma and an impressive track record of 47 completed studies since their inaugural trial in 2003, they continue to push boundaries in understanding this complex disease. Further expanding the list is Cleveland Clinic located in Cleveland where researchers are actively engaged with seven renal cell carcinoma trials while successfully completing twenty investigations from initiating its first recorded study on this specific cancer type back until year2009; noteworthy mention goes out recognizing M D Anderson Cancer Center's efforts located within Houston as another hub engagingly participating by having parallel accomplishments offering similar number (seven)of current actively running clinical tests whilst holding experience being partaken throughout thirty-six experiments starting right from earliest known research conducted two decades ago specifically targeting Renal Cell Carcinoma when traced way back until year 2000.
These renowned medical institutions reflect not only a commitment to advancing treatment options for patients battling renal cell carcinoma but also shining examples of collaboration and innovation across different locations nationwide. The tireless efforts exerted by these top-tier hospitals serve as beacons of hope for individuals affected by this challenging condition while propelling us closer towards breakthroughs that can potentially transform lives around the world
Which are the best cities for renal cell carcinoma clinical trials?
When it comes to renal cell carcinoma clinical trials, several cities stand out for their significant research efforts. In Boston, Massachusetts, there are 45 active trials focusing on promising treatments such as Nivolumab, Belzutifan, and Pembrolizumab/Quavonlimab. New york City follows closely with 40 ongoing studies exploring the efficacy of Pembrolizumab, BMS-986340, and DFF332. Houston in Texas also plays a crucial role with 31 active trials investigating treatments like Nivolumab and Pembrolizumab. These cities offer individuals battling renal cell carcinoma access to cutting-edge clinical trials that could potentially revolutionize treatment options and improve patient outcomes.
Which are the top treatments for renal cell carcinoma being explored in clinical trials?
Renal cell carcinoma research is making significant strides in uncovering new and effective treatments. Leading the way are several promising options being explored in clinical trials:
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Pembrolizumab: This breakthrough drug is currently undergoing testing in seven active trials for renal cell carcinoma. Since its introduction in 2013, it has been a key player in 60 all-time trials dedicated to fighting this type of cancer.
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Belzutifan: With six ongoing clinical trials and 14 all-time renal cell carcinoma studies, belzutifan shows promise as an emerging treatment option. It was first listed as a potential therapy in 2016.
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Nivolumab: Another formidable contender on the scene is nivolumab, with five active clinical trials and an impressive track record of participating in 91 all-time renal cell carcinoma studies since its initial listing back in 2012.
These innovative therapies bring hope to patients battling renal cell carcinoma and represent significant progress towards improved outcomes for affected individuals worldwide.
What are the most recent clinical trials for renal cell carcinoma?
Recent clinical trials for renal cell carcinoma offer new hope and potential treatment options for patients. One such trial, Arm 2, explores the combination of nivolumab, ipilimumab, and camu camu in a Phase 1 study. Additionally, ARM I focuses on standard care SBRT in a Phase 2 trial. Another promising study is Cohort 1's investigation into cabozantinib dose escalation during a Phase 2 trial. Furthermore, the Expansion Triplet combination holds promise as it undergoes evaluation in a Phase 2 study. Lastly, NPX267 is being tested in a Phase 1 trial to assess its efficacy against renal cell carcinoma. These recent clinical trials provide encouraging developments that may lead to improved outcomes for patients battling this challenging condition.
What renal cell carcinoma clinical trials were recently completed?
Several clinical trials investigating treatments for renal cell carcinoma have recently been completed, reflecting the ongoing efforts to advance therapeutic options for this form of kidney cancer. Notably, a trial sponsored by UNC Lineberger Comprehensive Cancer Center concluded in October 2020 and focused on evaluating Perflutren lipid microsphere as a potential treatment. In August 2020, two trials came to an end: one led by Arrowhead Pharmaceuticals exploring ARO-HIF2 therapy and another conducted by Celldex Therapeutics investigating CDX-527. These studies highlight the dedication of researchers and bring hope for future advancements against renal cell carcinoma.