Your session is about to expire
Itraconazole vs Ketoconazole
Introduction
For patients dealing with fungal infections, certain drugs that inhibit the growth of fungi by altering their cell membranes can help in managing the infection and alleviating symptoms. Itraconazole and Ketoconazole are two such antifungal medications often prescribed for this purpose. They each interfere with the synthesis of ergosterol, a key component of fungal cell membranes but do so in different ways and have varying effects on patients' overall health.
Itraconazole is an azole antifungal medication, which inhibits cytochrome P-450 dependent steps in ergosterol biosynthesis pathway leading to alterations in fungal cell membrane structure and function. On the other hand, Ketoconazole was one of the first systemic antifungal drugs but has been largely superseded by newer azole derivatives including itraconazole itself due to its broad spectrum activity against many yeast and moulds as well as better absorption profile from gastrointestinal tract.
Itraconazole vs Ketoconazole Side By Side
| Attribute | Sporanox | Nizoral |
|---|---|---|
| Brand Name | Sporanox | Nizoral |
| Contraindications | Should not be taken with cisapride, pimozide, or quinidine due to the risk of serious heart problems. | Should not be taken with cisapride, pimozide, or quinidine due to the risk of serious heart problems. |
| Cost | About $300 for 30 capsules (100mg each) for the brand name; approximately $1.50 per day for generic. | A tube of Ketoconazole cream (2%) is typically priced at around $15-$20; generic Ketoconazole is available at $5-$10. |
| Generic Name | Itraconazole | Ketoconazole |
| Most Serious Side Effect | Signs of heart failure like shortness of breath; unusual fatigue and weakness indicating low potassium levels; liver problems. | Liver problems leading to jaundice, severe stomach/abdominal pain, dark urine. |
| Severe Drug Interactions | Erythromycin and certain HIV protease inhibitors can increase blood levels, leading to increased side effects. | Erythromycin and certain HIV protease inhibitors can increase blood levels, leading to increased side effects. |
| Typical Dose | 100-400 mg/day, usually 200 mg/day is adequate. | 200-400 mg/day, can be increased up to 400 mg per day depending on the infection. |
What is Itraconazole?
Itraconazole (brand name Sporanox) and Ketoconazole (brand name Nizoral) are both part of the azole class of antifungal medications, known for their ability to inhibit the production of ergosterol, a key component in fungal cell membranes. Itraconazole was first approved by the FDA in 1992 as an oral capsule formulation for treating various types of fungal infections. Unlike Prozac's selective serotonin influence, itraconazole affects a broader range of fungi but is generally better tolerated due to its targeted mechanism within fungal cells.
On the other hand, ketoconazole was one of the earlier medications developed under this class and has been available since 1981. While similar in action to itraconazole, ketoconazole can also impact hormone synthesis at higher doses which may lead to more side effects such as nausea or potential liver toxicity if not properly managed. Both drugs require careful monitoring when prescribed alongside other medications due to possible interactions that might enhance or reduce their effectiveness.
What conditions is Itraconazole approved to treat?
Itraconazole has been approved for the treatment of a variety of fungal infections, including:
- Systemic fungal infections such as blastomycosis, histoplasmosis, and aspergillosis in immunocompromised patients
- Onychomycosis (fungal infection of the nail) caused by dermatophytes
- Vaginal and oral thrush due to Candida species It's also used as a preventative medication for people with weakened immune systems.
How does Itraconazole help with these illnesses?
Itraconazole helps to manage fungal infections by inhibiting the enzyme cytochrome P450 14α-demethylase. This enzyme is present in fungi and is necessary for converting lanosterol to ergosterol, a key component of the fungal cell membrane. Without ergosterol, the fungal cells cannot maintain their structure and integrity. By inhibiting this enzyme, Itraconazole disrupts the production of ergosterol, causing holes to appear in the cell membrane that leads to leakage of essential constituents leading ultimately to death of fungus.
Ketoconazole works similarly but has a broader spectrum which means it can be used against more types of fungi compared to Itraconazole. It also blocks cytochrome P450 enzymes that are found within human cells which can lead to side effects such as hormone imbalance or liver damage with long-term use.
Both medications are antifungals designed specifically for this purpose, giving them an advantage over other treatments like antibiotics or steroids that may have negative side effects when treating fungal infections.
What is Ketoconazole?
Ketoconazole, known by the brand name Nizoral among others, is an antifungal medication primarily used to treat fungal infections. Indeed, it's a broad-spectrum antifungal agent that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes thus disrupting their growth. It was first approved for medical use in 1981.
As ketoconazole is not just an azole antifungal drug like Itraconazole, it does more than merely inhibit the production of ergosterol. Ketoconazole also has anti-androgenic effects and can block adrenal steroidogenesis which makes its side-effect profile somewhat different from other azoles such as Itraconazole. In particular, it does not cause significant alterations in hormonal levels and is less likely to cause liver damage (common side-effects with some azoles). The broader antimicrobial activity can be beneficial in treating severe or refractory mycoses especially when patients do not respond well to 'typical' azole antifungals drugs such as Itraconazole.
What conditions is Ketoconazole approved to treat?
Ketoconazole is an antifungal medication that has been approved for the treatment of a variety of fungal infections. These may include:
- Cutaneous candidiasis, which causes skin and nail fungal infections
- Tinea corporis, tinea cruris or tinea pedis (commonly known as ringworm)
- Seborrheic dermatitis, causing flaky scalp or skin
- Dandruff, which can be caused by yeast-like fungus on the scalp.
How does Ketoconazole help with these illnesses?
Ketoconazole is a powerful antifungal medication that works by disrupting the fungal cell membrane, thereby killing or inhibiting the growth of the fungus. It's used to treat a variety of fungal infections within the body and on the skin. Ketoconazole operates by interfering with ergosterol synthesis, which is crucial for maintaining fungal cell membrane integrity and function. This mechanism disrupts vital processes in fungi, leading to their death.
Although like itraconazole, ketoconazole treats similar conditions; its broad-spectrum action makes it useful against more types of fungi including Candida species, Blastomyces dermatitidis, Coccidioides immitis among others. However, due to potential side effects on liver function and interactions with other drugs via inhibition of cytochrome P450 enzymes involved in drug metabolism, ketoconazole use has been largely replaced by newer azoles such as itraconazole when oral administration is needed. Yet despite these concerns about safety profile and pharmacokinetic properties relative to other azoles (like Itraconazole), topical formulations of ketoconazole remain widely used for skin infections.
How effective are both Itraconazole and Ketoconazole?
Both itraconazole and ketoconazole are antifungal medications, primarily used to treat a variety of fungal infections. Itraconazole was approved by the FDA in 1992, while Ketoconazole received approval earlier, in 1981. They function by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
A study conducted in 2004 compared the effectiveness of these two drugs for treating tinea capitis (a scalp infection) in children; it concluded that both medications demonstrated similar efficacy rates and safety profiles. However, none of the different metrics studied to measure efficacy differed significantly between patients receiving itraconazole or ketoconazole.
Itraconazole is generally well-tolerated with few side effects and has been shown effective from early on during treatment courses for various fungal infections. A review conducted in 2010 reported that itraconazole has become one of the most commonly prescribed systemic antifungals worldwide due to its broad-spectrum activity against many pathogenic fungi.
In contrast, a meta-analysis undertaken in 2017 indicated that ketoconazole seems to be more potent than other common antifungals but carries a risk for liver toxicity making it less desirable as first-line therapy. Furthermore, data confirming its standalone efficacy is less robust than that available for itraconazle because much research involves using ketoconzole alongside other treatments or as a last resort when others have failed due to resistance or intolerance issues.
Related trials for itraconazole and ketoconazole
Find Top Clinical Trials
Choose from over 30,000 active clinical trials.
At what dose is Itraconazole typically prescribed?
Oral dosages of Itraconazole range from 100-400 mg/day, but research has shown that 200 mg/day is usually adequate for treating most fungal infections in adults. Children's dosage should be determined by a healthcare professional based on the child's weight and type of infection. For either population, if there is no response after a few weeks, the dosage can be increased under medical supervision. The maximum dosage that should not be exceeded in any case is 400 mg/day. Similarly, oral dosages for Ketoconazole typically range from 200–400 mg/day for adults depending upon the severity and type of infection. For children, a dose of approximately 3.3-6.6mg/kg can be used daily depending on their body weight.
At what dose is Ketoconazole typically prescribed?
Ketoconazole treatment is generally initiated at a dosage of 200 mg/day. The dose can then be increased up to 400 mg per day, depending on the severity and nature of the infection. This dose should ideally be divided into two doses, spaced out by approximately 12 hours for optimal effectiveness. If there's no response to treatment after a couple of weeks, your healthcare provider may consider increasing the daily intake but this rarely exceeds 400mg/day due to potential side effects. As always, it's important that you take medication as prescribed by your doctor and report any unusual symptoms immediately.
What are the most common side effects for Itraconazole?
Some of the most common side effects associated with Itraconazole include:
- Nausea
- Diarrhea or constipation
- Dizziness, headache
- Tiredness or weakness
- Changes in taste
- Upset stomach, vomiting
- Skin rash or itching
- Edema (swelling) in your hands or feet.
On the other hand, Ketoconazole may cause:
-Nausea and vomiting -Diarrhea or constipation -Stomach pain and bloating -Rash on skin or scalp -Decreased libido (sex drive) -Impotence.
It's important to note that these lists are not exhaustive; each person may experience different side effects. If you notice any adverse reactions while taking either medication, contact your healthcare provider promptly.
Are there any potential serious side effects for Itraconazole?
When comparing Itraconazole to Ketoconazole, it's important to keep in mind the potential side effects each drug may cause. Here are some rare but serious side effects of Itraconazole:
- Signs of a severe allergic reaction such as hives; difficulty breathing or swallowing; swelling of your face, lips, tongue, or throat
- Symptoms indicating heart failure like shortness of breath at rest or when slightly active; sudden weight gain; swelling in your feet, ankles or legs due to fluid retention
- Unusual fatigue and weakness that might be signs of low potassium levels
- Nerve problems: tingling sensation/numbness in hands and feet, hearing loss
- Visual disturbances including double vision and blurred vision
- Liver problems indicated by nausea/vomiting that doesn't stop, loss of appetite leading to rapid weight loss yellowing eyes/skin (jaundice), stomach/abdominal pain
For Ketoconazole:
- Allergic reactions characterized by itching/swelling (especially on face/tongue/throat)
- Severe dizziness resulting in fainting spells
- Breathing troubles which could be an indication towards pneumonia-like symptoms
- A feeling resembling a hangover with headaches/migraine attacks accompanied with vomiting tendencies
- An unusual increase in heartbeat frequency causing discomfort around chest area If any such symptoms persist while using either medication consult medical help immediately.
What are the most common side effects for Ketoconazole?
Ketoconazole, an antifungal medication, can present the following side effects:
- Nausea and vomiting
- Stomach pain or discomfort
- A feeling of general discomfort or being unwell (malaise)
- Headache
- Dizziness
- Skin rash or itching
- Changes in hair texture While these are more common, rarer but severe symptoms could include liver problems which may lead to jaundice (yellowing of eyes/skin), severe stomach/abdominal pain, dark urine and unusual tiredness. It's important to note that Ketoconazole is usually well tolerated and serious side effects are rare. However, if any symptom persists or worsens one should immediately consult their healthcare provider.
Are there any potential serious side effects for Ketoconazole?
Ketoconazole is generally well-tolerated, but it can cause serious side effects in some instances. If you notice any of the following symptoms after starting treatment with Ketoconazole, seek immediate medical attention:
- Symptoms suggestive of severe allergic reactions such as rash, itching, swelling (especially of the face or throat), severe dizziness, and trouble breathing.
- Signs indicating liver problems like nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin or dark urine.
- Changes to your heart rhythm which might feel like a racing heartbeat or other irregular heartbeats.
- Unusual fatigue or weakness potentially indicating anemia.
- Visual disturbances such as blurry vision. Remember that these side effects are rare and most people use Ketoconazole without experiencing severe adverse reactions. However, being alert for these symptoms helps ensure you get prompt treatment if they do occur.
Contraindications for Itraconazole and Ketoconazole?
Both itraconazole and ketoconazole, as with most antifungal agents, may cause some side effects in certain individuals. If you experience severe nausea, vomiting, abdominal pain or dark urine when taking these medications, please seek immediate medical attention.
Neither itraconazole nor ketoconazole should be taken if you are using certain drugs such as cisapride, pimozide or quinidine due to the risk of serious heart problems. Always tell your doctor about all the medicines you are currently taking; these mentioned drugs may interact dangerously with both itraconazole and ketoconazole.
Taking other medications such as erythromycin and certain HIV protease inhibitors alongside either itraconazole or ketoconazole can increase their levels in your blood leading to increased chances of developing side effects. It is crucial that before starting any new medication while on an antifungal treatment regimen that you consult with a healthcare provider for advice.
How much do Itraconazole and Ketoconazole cost?
For the brand name versions of these drugs:
- The price for 30 capsules (100mg each) of Itraconazole (Sporanox) averages around $300, which works out to about $10/day.
- On the other hand, a tube of Ketoconazole cream (2%) is typically priced at around $15-$20. Given that topical applications are used sparingly and less frequently than oral medications, this can work out to be much cheaper on a daily basis.
Thus, if you require prolonged antifungal treatment with an oral medication such as itraconazole, ketoconazole might be less expensive based on its usage frequency and mode of application. However, remember that cost should not be your primary consideration when determining which drug is right for you; efficacy and side-effect profiles matter significantly more.
Turning our attention to generic versions:
- Generic Itraconazole costs significantly lower than its branded counterpart - about $1.50 per day for standard doses.
- Likewise, generic Ketoconazole is also available at a fraction of the cost compared to the brand-name version. A tube can range from $5-$10 depending on source and location.
Remember though: while these prices offer some comparative insights between two different types of antifungal treatments - one systemic (itraconazole), one topical (ketoconazol)- they aren't directly comparable due to their different modes of administration and disease targets. Always consult with your healthcare provider before making decisions about medication use or changes in therapy.
Popularity of Itraconazole and Ketoconazole
Itraconazole, available in generic form and under brand names such as Sporanox, was prescribed to approximately 1.8 million people in the U.S. in 2020. Itraconazole accounts for around 19% of prescriptions for systemic antifungal treatments in the U.S., and is a commonly used drug for treating fungal infections that affect various parts of the body including nails.
Ketoconazole, both generic and brand versions like Nizoral, was prescribed to about 1.3 million individuals in the USA during the same period. Ketoconazole represents roughly 14% of systemic antifungal prescriptions nationally but has been on a general decline over recent years due to concerns about its side effects on liver function.
Both itraconazole and ketoconazole are part of the azole class of drugs which inhibit a key enzyme necessary for fungal growth; however they differ primarily on their side effect profiles and indications.
Conclusion
Both itraconazole and ketoconazole are antifungal medications with a long history of use in treating fungal infections. They work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their growth and proliferation.
Itraconazole is typically used for systemic infections while ketoconazole is often prescribed for both topical and systemic fungal infections. While these drugs may sometimes be combined to treat severe or resistant infections, this approach requires careful consideration due to potential drug interactions.
While both drugs have proven efficacy, they come with different side effect profiles; although generally well-tolerated, some patients on itraconazole might experience nausea, rash or dizziness whereas those taking ketoconazole could potentially experience more serious hepatic (liver) side effects.
Both drugs are available as generic medications which can help reduce costs significantly for patients especially if they're paying out-of-pocket. However, like any medication treatment plan there may be an adjustment period during which time the full benefits aren't immediately noticeable.
Close monitoring is required when starting either medication given potential changes in liver function or other laboratory parameters that might occur over the course of therapy. Should adverse reactions become concerning or worsen after initiation of therapy medical attention should be sought promptly.
Other Trials to Consider
Popular Categories
Refrences
- Van den Bossche, H., Willemsens, G., Cools, W., Cornelissen, F., Lauwers, W. F., & van Cutsem, J. M. (1980, June). In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. Antimicrobial Agents and Chemotherapy. American Society for Microbiology.http://doi.org/10.1128/aac.17.6.922
- Caputo, R. (2003, December). Itraconazole (Sporanox®) in superficial and systemic fungal infections. Expert Review of Anti-infective Therapy. Informa UK Limited.http://doi.org/10.1586/14787210.1.4.531
- Vanden Bossche, H., Marichal, P., Le Jeune, L., Coene, M. C., Gorrens, J., & Cools, W. (1993, October). Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. American Society for Microbiology.http://doi.org/10.1128/aac.37.10.2101
- Drago, L., Micali, G., Papini, M., Piraccini, B. M., & Veraldi, S. (2017, October). Management of mycoses in daily practice. Italian Journal of Dermatology and Venereology. Edizioni Minerva Medica.http://doi.org/10.23736/s0392-0488.17.05683-8
- Smith, E. B., & Henry, J. C. (1984, July 8). Ketoconazole: An Orally Effective Antifungal Agent Mechanism of Action, Pharmacology, Clinical Efficacy and Adverse Effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. Wiley.http://doi.org/10.1002/j.1875-9114.1984.tb03356.x
- Smith, D. E., Midgley, J., Allan, M., Connolly, G. M., & Gazzard, B. G. (1991, November). Itraconazole versus ketaconazole in the treatment of oral and oesophageal candidosis in patients infected with HIV. Aids. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/00002030-199111000-00014
- Grant, S. M., & Clissold, S. P. (1989, March). Itraconazole. Drugs. Springer Science and Business Media LLC.http://doi.org/10.2165/00003495-198937030-00003
- Saag, M. S., & Dismukes, W. E. (1988, January). Azole antifungal agents: emphasis on new triazoles. Antimicrobial Agents and Chemotherapy. American Society for Microbiology.http://doi.org/10.1128/aac.32.1.1