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Vigamox vs Besivance
Introduction
For patients dealing with bacterial conjunctivitis or other eye infections, a specific group of drugs that inhibit the growth of bacteria can be instrumental in managing symptoms and hastening recovery. Vigamox and Besivance are two such medications that are prescribed for these conditions. They each work by preventing the multiplication of bacteria but have different compositions.
Vigamox is a fluoroquinolone-type antibiotic known chemically as moxifloxacin, which stops the reproduction of DNA gyrase—a type of enzyme bacteria require to reproduce. On the other hand, Besivance contains besifloxacin—another fluoroquinolone antibiotic—but it's designed with DuraSite®, a delivery system meant to increase contact time on the ocular surface. This might enhance its efficacy against certain microorganisms compared to traditional formulations.
While both drugs aim at treating bacterial infections in eyes, their choice depends upon various factors including patient's medical history, severity and type of infection as well as potential side effects.
Vigamox vs Besivance Side By Side
| Attribute | Vigamox | Besivance |
|---|---|---|
| Brand Name | Vigamox | Besivance |
| Contraindications | Allergic reactions, use with certain antifungals or steroids, wearing contact lenses unless advised by a healthcare provider | Allergic reactions, use with certain antifungals or steroids, wearing contact lenses unless advised by a healthcare provider |
| Cost | $185 for a 3 ml bottle | $215 for a 5 ml bottle |
| Generic Name | Moxifloxacin | Besifloxacin |
| Most Serious Side Effect | Signs of a severe allergic reaction, severe discomfort or redness in the eyes, eye pain or changes in vision, oozing or discharge from the eyes | Signs of an allergic reaction, severe skin reactions like rash with fever, vision changes that persist after treatment has stopped |
| Severe Drug Interactions | Negative interactions with certain antifungals or steroids | No known interactions with other drugs like Vigamox does (with antacids for instance) |
| Typical Dose | One drop in the affected eye(s) three times a day for 7 days | 1 drop in the affected eye(s) every 2 hours while awake for two days (up to eight times a day), then 1 drop approximately every 4 hours while awake for five additional days |
What is Vigamox?
Moxifloxacin (the generic name for Vigamox) is an antibiotic that belongs to the fluoroquinolone class of antibiotics, which marked a significant advancement over earlier classes of antibiotic drugs. Moxifloxacin was first approved by the FDA in 1999. It works by inhibiting bacterial enzymes necessary for DNA replication, thereby effectively halting bacterial growth and allowing the immune system to eliminate the infection. It is prescribed for treating different forms of bacterial infections, particularly those affecting eyes like conjunctivitis.
On the other hand, Besifloxacin (sold under brand name Besivance) also belongs to the same fluoroquinolone class but is more selective in targeting bacteria causing eye infections with less impact on beneficial gut flora due to its limited systemic absorption. This results in it having fewer side effects related to gastrointestinal disturbances compared with other antibiotics that have broader systemic effects.
What conditions is Vigamox approved to treat?
Vigamox is approved for the treatment of various ocular bacterial infections, including:
- Bacterial conjunctivitis, also known as pink eye
- Preoperative prophylaxis in cataract surgery
These are similar to conditions that Besivance is used for. However, Vigamox has a broader spectrum and can be used in patients from 1 year old and above while Besivance can only be used in patients who are at least two years old.
How does Vigamox help with these illnesses?
Vigamox works to fight bacterial infections in the eye by interfering with a process bacteria need for their growth and multiplication. It does this by inhibiting an enzyme called DNA gyrase, which is involved in untangling the DNA strands during replication. This interference ultimately leads to the death of bacterial cells, thus aiding in clearing up infections.
DNA is not only vital for human cell function but also essential for bacterial life processes including reproduction, metabolism, and protein synthesis. By blocking DNA gyrase—an enzyme that plays key roles in these processes—Vigamox can effectively limit bacterial proliferation and help patients manage their condition.
Just like Vigamox, Besivance also has anti-bacterial properties that combat eye infections. However, it operates differently as it obstructs bacterial cell wall synthesis leading to cell death. Both drugs have been proven effective against a variety of bacteria types common to eye infection but individual patient response may vary due to factors such as allergy or resistance.
What is Besivance?
Besivance is a brand name for besifloxacin, an antibiotic that belongs to the fluoroquinolone family. This means it works by preventing bacteria from reproducing and repairing themselves, thereby effectively killing them off. Besifloxacin was first approved by the FDA in 2009 as an ophthalmic solution (eye drop) specifically for treating bacterial conjunctivitis, or "pink eye". Unlike Vigamox which can be used systemically, Besivance is designed solely for topical ocular use. Its ability to concentrate quickly in tear film after administration provides targeted treatment of surface ocular infections. Potential side effects are localized and relatively mild compared to systemic medications - they can include blurred vision and eye discomfort upon instillation, but not typically insomnia or sexual dysfunction common with some systemic drugs such as Prozac. For severe or unresponsive cases of bacterial conjunctivitis where other treatments have failed, Besivance might be an appropriate choice due to its broad spectrum efficacy against many common causative pathogens.
What conditions is Besivance approved to treat?
Besivance is an antibiotic eye drop that has been approved for use in the treatment of:
- Bacterial conjunctivitis, also known as “pink eye”
- Preventing bacterial infections post-eye surgeries such as cataract surgery.
It's crucial to note that Besivance should only be used under prescription and supervision by a healthcare provider due to its potential side effects.
How does Besivance help with these illnesses?
Besivance is an antibiotic eye drop commonly used to treat bacterial conjunctivitis, or pink eye. It works by inhibiting DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This action effectively halts the growth of bacteria in your eyes and allows your immune system time to eradicate the infection.
Compared to Vigamox, another popular antibiotic eye drop option which targets a similar range of bacteria but through different mechanisms of action - Besivance has distinct advantages. For one thing, Besivance has been designed with a unique formulation that enhances its ability to penetrate ocular tissues more deeply than other antibiotics, thus increasing its efficacy against deep-seated infections.
Additionally because it does not have known interactions with other drugs like Vigamox does (with antacids for instance), Besivance could be prescribed when patient's current medication routine makes using alternative treatments less effective or potentially dangerous.
How effective are both Vigamox and Besivance?
Both moxifloxacin (Vigamox) and besifloxacin (Besivance) are broad-spectrum fluoroquinolone antibiotics used for treating bacterial conjunctivitis, or pink eye. They were approved by the FDA in 2003 and 2009 respectively, acting on different enzymes to prevent bacterial DNA replication, hence they may be prescribed under different circumstances such as varying microbial susceptibilities.
The effectiveness of Vigamox was directly studied in a double-blind clinical trial in 2005; it exhibited efficacy in managing symptoms of bacterial conjunctivitis with a promising safety profile. In this study, none of the different metrics studied to measure efficacy differed between patients receiving Vigamox and those receiving other similar treatments. A later clinical trial compared Besivance against Vigamox noting that Besivance had somewhat higher rates of microbiological eradication due to its increased potency against certain bacterial strains.
A review highlighted that both drugs start showing optimal efficacy from the first day of treatment. Their side effect profiles are generally favorable over many other antibiotics for ocular use and they are usually well tolerated even among elderly populations. As these medications belong to one of the most widely prescribed antibiotic classes globally, their effectiveness is supported by significant history and ongoing research.
While there has been some concern regarding resistance development with fluoroquinolones like moxifloxacin especially among older-generation drugs, besifloxacin’s unique structure makes it less prone to existing mechanisms of fluoroquinolone resistance which might make it a preferred option when resistance is suspected but overall both remain effective options for treating conjunctival infections.
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At what dose is Vigamox typically prescribed?
Eye drop dosages of Vigamox typically start with one drop in the affected eye(s) three times a day for 7 days. However, based on the severity and response to the infection, your doctor may adjust this dosage. Besivance, on the other hand, is usually prescribed as one drop into the conjunctival sac of each infected eye every 2 hours while awake for two days (up to eight times daily), then it's reduced to one drop approximately every 4 hours while awake for next five days. As with any medication regimen, these dosages should not be altered without consulting your healthcare provider.
At what dose is Besivance typically prescribed?
Treatment with Besivance, which is an antibiotic eye drop used to treat bacterial conjunctivitis, generally starts with 1 drop in the affected eye(s) every 2 hours while awake for two days (up to eight times a day). Then, it can be reduced to one drop in the affected eye(s) approximately every four hours while awake for five additional days. This makes a complete treatment course of seven days. If there's no response or if symptoms get worse after several days of treatment, you should contact your healthcare provider immediately. It's important not to exceed the recommended dosage without professional advice since overuse could lead to decreased effectiveness and increased side effects.
What are the most common side effects for Vigamox?
Common side effects of Vigamox and Besivance, both used to treat bacterial eye infections, can include:
- Mild irritation or discomfort in the eyes
- Blurred vision immediately after applying drops
- Watery eyes
- Redness in the white part of your eye or inner eyelid
- Puffy eyelids.
Remember that these are potential side effects; not all individuals will experience them. If any symptoms persist or you notice severe reactions such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, consult a healthcare professional promptly.
Are there any potential serious side effects for Vigamox?
While comparing Vigamox to Besivance, it's important to note that both are antibiotics used for eye infections and generally have minimal side effects. However, in rare cases, serious side effects can occur such as:
- Signs of a severe allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue or throat.
- Severe discomfort or redness in the eyes
- Eye pain or changes in vision
- Oozing or discharge from the eyes
- Slow heartbeats; weak pulse; fainting and shortness of breath
- Headache with chest pain and severe dizziness
It's also worth noting that while using these medications you should avoid wearing contact lenses unless your doctor has instructed otherwise. Should any of these symptoms manifest after application, stop usage immediately and seek medical assistance promptly. Neither medication is associated with serotonin syndrome nor drastic mental health alterations like suicidal thoughts.
What are the most common side effects for Besivance?
Besivance, an antibiotic eye drop used to treat bacterial infections of the eye, can have some side effects that patients need to be aware of. Some common ones include:
- Eye discomfort or irritation
- Blurred vision
- Redness in the eyes
- Temporary unstable vision
- Headaches Some less common but serious side effects could also occur such as allergic reactions leading to rash, itching/swelling (especially of the face/tongue/throat), severe dizziness and trouble breathing. If you notice any unusual symptoms while using Besivance, it's advisable to seek immediate medical attention.
Are there any potential serious side effects for Besivance?
While Besivance is generally well-tolerated, there are some potential side effects you should be aware of. These include:
- Signs of an allergic reaction, such as difficulty breathing; swelling of your face, lips, tongue or throat.
- Severe skin reactions like skin rash with fever; swollen glands; muscle aches or weakness; severe blistering or peeling.
- Vision changes that persist after treatment has stopped.
- Eye pain or increased tear production.
- Itching, redness, irritation or other eye discomfort not present before using this medication.
It's important to remember that while these side effects are possible, they are rare and most people do not experience them. If any of these signs appear while using Besivance it's essential to discontinue use immediately and seek medical attention.
Contraindications for Vigamox and Besivance?
Both Vigamox and Besivance, as with most other antibiotic medications, can cause allergic reactions in some people. If you notice symptoms such as redness, swelling or itching after using these eye drops, seek immediate medical attention.
Vigamox and Besivance should not be used if you are currently taking certain drugs that interact negatively with them like antifungals or steroids. Always inform your physician about any medications you are taking; some of these will require a period of time to clear from the system to prevent dangerous interactions with Vigamox and Besivance.
Remember to avoid wearing contact lenses during treatment unless advised otherwise by your healthcare provider since both antibiotics may adhere to the lens causing further irritation. Also, always administer the medication exactly as prescribed by your doctor for the full duration of treatment even if symptoms subside early on in order to ensure complete elimination of bacteria.
How much do Vigamox and Besivance cost?
For the brand name versions of these drugs:
- The price for a 3 ml bottle of Vigamox (moxifloxacin ophthalmic solution) averages around $185, though costs may vary depending on your pharmacy and location. Typically used three times a day during treatment, this could roughly equate to about $20 per day.
- Besivance (besifloxacin ophthalmic suspension), is priced at approximately $215 for a 5 ml bottle. Given that it's typically applied three times daily, this works out to nearly $14/day.
Thus, if you are following typical dosage instructions for each eye drop medication, then brand-name Besivance generally proves to be less expensive on a per-day treatment basis. However, cost should not be the primary consideration in determining which of these medications is right for you.
There are currently no generic equivalents available in the United States for either Vigamox or Besivance; therefore prices remain relatively high compared to other medications where generics are readily accessible.
Popularity of Vigamox and Besivance
Moxifloxacin, available under the brand name Vigamox, is a popular choice for bacterial eye infections and was estimated to have been prescribed to about 3.5 million people in the US in 2020. Moxifloxacin accounted for around 10% of antibiotic eye drop prescriptions in the US. With its broad-spectrum antibacterial activity and high corneal penetration, it's often selected as first-line therapy for bacterial conjunctivitis.
Besifloxacin ophthalmic suspension (brand name Besivance), however, holds a smaller share of the market compared to moxifloxacin but has shown steady growth since its release due largely to its efficacy against multi-drug resistant strains. In the US in 2020, besifloxacin was prescribed approximately 1 million times making up just over 2% of all antibiotic eye drop prescriptions. Both drugs are fluoroquinolones with similar safety profiles and application frequencies; however, your doctor may prefer one over another based on specific bacteria sensitivity information or patient factors.
Conclusion
Vigamox (moxifloxacin) and Besivance (besifloxacin) are both broad-spectrum fluoroquinolone antibiotics used to treat bacterial eye infections. Both medications have demonstrated effectiveness in clinical trials, with a comparable range of bacteria susceptible to each.
The key difference between the two is their formulation; Vigamox comes as an ophthalmic solution while Besivance is available as an ophthalmic suspension. This means that Vigamox will be clear when applied, whereas Besivance may appear cloudy due to its suspended particles but this does not affect its efficacy.
Both drugs are typically well-tolerated with similar side effect profiles including minor eye discomfort or irritation after administration. Serious side effects are rare but seek immediate medical attention if you notice any signs of allergic reactions such as rash, itching/swelling or severe dizziness.
It's also essential for patients on either medication to monitor their symptoms closely. Any worsening condition or lack of improvement should warrant a prompt consultation with your healthcare provider.
While both drugs may not show noticeable effects immediately upon starting treatment, they should start working within a few days given proper adherence to the prescribed regimen and dosage instructions. The availability of generic versions for both medications can help yield cost savings especially for out-of-pocket paying patients.
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Refrences
- Robertson, S. M., Curtis, M. A., Schlech, B. A., Rusinko, A., Owen, G. R., Dembinska, O., … Dahlin, D. C. (2005, November). Ocular Pharmacokinetics of Moxifloxacin After Topical Treatment of Animals and Humans. Survey of Ophthalmology. Elsevier BV.http://doi.org/10.1016/j.survophthal.2005.07.001
- Silver, L. H., Woodside, A. M., & Montgomery, D. B. (2005, November). Clinical Safety of Moxifloxacin Ophthalmic Solution 0.5% (VIGAMOX®) in Pediatric and Nonpediatric Patients With Bacterial Conjunctivitis. Survey of Ophthalmology. Elsevier BV.http://doi.org/10.1016/j.survophthal.2005.05.004
- McDonald, M. B., Protzko, E. E., Brunner, L. S., Morris, T. W., Haas, W., Paterno, M. R., … Usner, D. W. (2009, September). Efficacy and Safety of Besifloxacin Ophthalmic Suspension 0.6% Compared with Moxifloxacin Ophthalmic Solution 0.5% for Treating Bacterial Conjunctivitis. Ophthalmology. Elsevier BV.http://doi.org/10.1016/j.ophtha.2009.05.014
- Schwab, I. R., Friedlaender, M., McCulley, J., Lichtenstein, S. J., & Moran, C. T. (2003, March). A phase III clinical trial of 0.5% levofloxacin ophthalmic solution versus 0.3% ofloxacin ophthalmic solution for the treatment of bacterial conjunctivitis. Ophthalmology. Elsevier BV.http://doi.org/10.1016/s0161-6420(02)01894-8