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What is Cycloset
BromocriptineThe Generic name of this drug
Treatment SummaryBromocriptine mesylate is a medication used to treat symptoms of Parkinsonian Syndrome, a neurological disorder. It can also be used to reduce levels of the hormone prolactin in patients with too much of it in their system, and suppress growth hormone in people with acromegaly. There is a risk of developing pulmonary fibrosis when taking this drug.
Parlodelis the brand name
Cycloset Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Parlodel
Bromocriptine
1978
25
Approved as Treatment by the FDA
Bromocriptine, commonly known as Parlodel, is approved by the FDA for 6 uses like Hyperprolactinemia and Type 2 Diabetes Mellitus .Hyperprolactinemia
Helps manage Hyperprolactinemia
Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Hyperprolactinemia
Helps manage Hyperprolactinemia
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Parkinson's Disease
Acromegaly
Helps manage Acromegaly
Effectiveness
How Cycloset Affects PatientsBromocriptine works by activating certain dopamine receptors in the brain, which help reduce symptoms of movement disorders and improve dopamine activity. It also affects other receptor types, including serotonin receptors, alpha-2 adrenergic receptors, and dopamine D1 receptors. As a result, it can help treat Parkinson's syndrome by restoring dopamine activity in the brain. It can also help reduce prolactin secretion and has been linked to hallucinations and delusions (similar to those experienced by people with schizophrenia). Side effects related to bromocriptine may include pulmonary fibrosis due to its effects on some serotonin receptors.
How Cycloset works in the bodyThe dopamine D2 receptor is a protein that sits on the surface of cells and is linked to G proteins. When it is activated, it stops certain chemicals from entering the cell, which lowers the amount of calcium in the cell. It also blocks certain proteins from being activated, which helps stop the cell from growing and dividing. Finally, it helps to improve coordination in people with movement disorders by activating the same pathway in the part of the brain responsible for movement.
When to interrupt dosage
The suggested measure of Cycloset is contingent upon the diagnosed condition, including Hyperprolactinemia, Acromegaly and Parkinson's Disease. The dosage is dependent on the delivery approach (e.g. Oral or Capsule) as specified in the table beneath.Condition
Dosage
Administration
neuroleptic malignant syndrome (NMS)
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hyperprolactinemia
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Acromegaly
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Parkinson's Disease
2.5 mg, , 5.0 mg, 0.8 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Warnings
Cycloset ContraindicationsCondition
Risk Level
Notes
Acromegaly, Prolactinoma, Parkinson's Disease
Do Not Combine
Hypertensive disease
Do Not Combine
Coronary Artery Disease
Do Not Combine
Heart Disease
Do Not Combine
treatment withdrawal during pregnancy
Do Not Combine
Pulse Frequency
Do Not Combine
Common Cycloset Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Bromocriptine may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Bromocriptine may increase the hypertensive and vasoconstricting activities of Abediterol.
Acepromazine
Major
Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Cycloset Toxicity & Overdose RiskOverdosing on Metoprolol can cause nausea, vomiting, and abnormally low blood pressure. Other common side effects include headaches, dizziness, constipation, feeling faint, abdominal pain, stuffy nose, diarrhea, and low blood pressure.
Cycloset Novel Uses: Which Conditions Have a Clinical Trial Featuring Cycloset?
Currently, 217 active trials are being conducted to determine the effectiveness of Cycloset in the management of Acromegaly, Hyperprolactinemia and Neuroleptic Malignant Syndrome (NMS).Condition
Clinical Trials
Trial Phases
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Acromegaly
5 Actively Recruiting
Phase 3, Phase 2, Not Applicable
neuroleptic malignant syndrome (NMS)
0 Actively Recruiting
Hyperprolactinemia
0 Actively Recruiting
Type 2 Diabetes
155 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Cycloset Reviews: What are patients saying about Cycloset?
5Patient Review
8/18/2011 Not only has my sex drive increased since taking this medication, but I've also noticed a reduction in hot flashes and night sweats. Additionally, I believe that I have ADD and this medicine has allowed me to stay focused on one task at a time rather than becoming easily distracted.
5Patient Review
2/1/20114.3Patient Review
7/17/2012 I'm a 53 year old man with type 2 diabetes. I started taking Cycloset on 12/1/11 and had an episode of syncope (a brief loss of consciousness) and nausea. This was thought to be due to an interaction with Sudafed, so I reduced the dosage to 2 tablets per day without Sudafed. However, I had another episode of syncope and nausea on 2/5. My blood sugar was never improved with this medication, so I am discontinuing it immediately.
3.3Patient Review
11/10/2011 This is a new drug, and so far I've seen good effects from it.
3.3Patient Review
9/22/2013 I found that my blood pressure would drop after taking this medication, so be cautious if you have a similar condition.
2Patient Review
7/12/2014 I was given this medication for Type 2 diabetes in an effort to lower my A1C. I had tried other medications before, but none of them worked. This one also made my FBS go higher, which is not what I needed.
1.7Patient Review
8/18/2013 I did not have a good experience with this treatment. I felt awful while taking it and my blood sugar spiked pretty significantly. My feet also swelled up, which was new for me. Within a day of stopping the medication, I already felt so much better.
1Patient Review
11/16/2012 Cycloset gave me awful flu-like symptoms that made my stomach hurt, constantly nauseous, and lethargic. I refused to take it after almost a year of this because my doctor switched me to Amryl, which is working great.
1Patient Review
4/15/2014 I felt awful after taking this medication. I had a rapid heart rate, felt dizzy and weak, and just generally unwell.
Patient Q&A Section about cycloset
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is cycloset syrup used for periods?
"Cycloset bromocriptine is used to treat certain menstrual problems, like amenorrhea, in women. It also stops milk production in some men and women who have abnormal milk leakage. Lastly, it is used to treat infertility in both men and women that occurs because the body is making too much prolactin."
Answered by AI
How does cycloset work?
"As your blood sugar decreases, so does your risk for heart disease and other diabetes-related complications.
CYCLOSET helps control blood sugar by increasing insulin sensitivity in adults with type 2 diabetes. Insulin is the hormone your body produces to help change blood sugar into energy, and CYCLOSET helps lower blood sugar levels. As your blood sugar decreases, your risk for heart disease and other diabetes-related complications also decreases."
Answered by AI
What drug class is cycloset?
"Cycloset is a prescription medication used to treat the symptoms of Type 2 diabetes Mellitus. Cycloset may be used alone or with other medications. Cycloset belongs to a class of drugs called Dopamine Agonists, which are drugs that act on the dopamine system in the brain."
Answered by AI
What is cycloset used for?
"The drug CYCLOSET (bromocriptine mesylate) is indicated for use by adults with type 2 diabetes, in conjunction with diet and exercise, to lower blood sugar levels. CYCLOSET is not recommended for use by people with type 1 diabetes or by those with diabetic ketoacidosis."
Answered by AI